Numerous studies have examined on a micro and macro level factors that influence innovation at the individual, agency, or business level. Yet there is little research on cross-national variables associated with innovation at the nation-state scale. Drawing upon existing databases, this paper examines the factors associated with some countries being labeled as more or less innovative, suggesting policies that might be enacted to promote social innovation and management. It finds that national innovation rankings are modestly correlated with democratic freedoms, control of corruption, regulatory quality, and percentage of the population with tertiary education. However when a multifactor test is performed, these factors provide significant evidence of cross-national and aggregate determinants associated with innovation.