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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">46818</article-id><article-id pub-id-type="doi">10.22363/2313-0245-2025-29-1-116-123</article-id><article-id pub-id-type="edn">GTYRAJ</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>therapeutic profile diseases</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>БОЛЕЗНИ ТЕРАПЕВТИЧЕСКОГО ПРОФИЛЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Nontuberculous mycobacterial pulmonary disease</article-title><trans-title-group xml:lang="ru"><trans-title>Нетуберкулезный микобактериоз легких</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0514-9114</contrib-id><contrib-id contrib-id-type="spin">1032-9122</contrib-id><name-alternatives><name xml:lang="en"><surname>Roytberg</surname><given-names>Grigory E.</given-names></name><name xml:lang="ru"><surname>Ройтберг</surname><given-names>Г. Е.</given-names></name></name-alternatives><email>bulanovanatalia@outlook.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-4102-6276</contrib-id><name-alternatives><name xml:lang="en"><surname>Gritzay</surname><given-names>Alla A.</given-names></name><name xml:lang="ru"><surname>Грицай</surname><given-names>А. А.</given-names></name></name-alternatives><email>bulanovanatalia@outlook.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5738-0740</contrib-id><contrib-id contrib-id-type="spin">5217-8213</contrib-id><name-alternatives><name xml:lang="en"><surname>Davydova</surname><given-names>Alina Sh.</given-names></name><name xml:lang="ru"><surname>Давыдова</surname><given-names>А. Ш.</given-names></name></name-alternatives><email>bulanovanatalia@outlook.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7559-7030</contrib-id><contrib-id contrib-id-type="spin">1306-8984</contrib-id><name-alternatives><name xml:lang="en"><surname>Bulanova</surname><given-names>Natalia A.</given-names></name><name xml:lang="ru"><surname>Буланова</surname><given-names>Н. А.</given-names></name></name-alternatives><email>bulanovanatalia@outlook.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Pirogov Russian National Research Medical University</institution></aff><aff><institution xml:lang="ru">Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Joint Stock Company «Medicina»</institution></aff><aff><institution xml:lang="ru">Акционерное общество «Медицина»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2025</year></pub-date><volume>29</volume><issue>1</issue><issue-title xml:lang="en">PHYSIOLOGY. EXPERIMENTAL PHYSIOLOGY</issue-title><issue-title xml:lang="ru">ФИЗИОЛОГИЯ. ЭКСПЕРИМЕНТАЛЬНАЯ ФИЗИОЛОГИЯ</issue-title><fpage>116</fpage><lpage>123</lpage><history><date date-type="received" iso-8601-date="2025-11-01"><day>01</day><month>11</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Roytberg G.E., Gritzay A.A., Davydova A.S., Bulanova N.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Ройтберг Г.Е., Грицай А.А., Давыдова А.Ш., Буланова Н.А.</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Roytberg G.E., Gritzay A.A., Davydova A.S., Bulanova N.A.</copyright-holder><copyright-holder xml:lang="ru">Ройтберг Г.Е., Грицай А.А., Давыдова А.Ш., Буланова Н.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/46818">https://journals.rudn.ru/medicine/article/view/46818</self-uri><abstract xml:lang="en"><p>The article presents a case report of nontuberculous mycobacterial pulmonary disease. Nontuberculous mycobacterial pulmonary disease is frequently underdiagnosed due to the absence of clinical signs, a nonspecific X-ray picture, as well as the difficulties of using molecular genetic diagnostic tests in primary health care setting. Some patients especially those with underlying respiratory diseases, are at increased risk of developing nontuberculous mycobacterial pulmonary disease. Identification of patients at risk is essential to allow for prompt testing and diagnosis and appropriate management to prevent disease progression.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлен клинический случай нетуберкулезного микобактериоза легких. Диагностика нетуберкулезного микобактериоза легких на ранних этапах заболевания затруднена в связи с отсутствием патогномоничных симптомов, неспецифичностью рентгенологической картины, а также трудностями применения современных молекулярно-генетических методов диагностики на этапе первичного звена здравоохранения. Признаками возможного присоединения нетуберкулезного микобактериоза легких являются неэффективность лечения хронических заболеваний легких, их длительное течение, частые обострения. Пациенты с этими признаками составляют группу риска нетуберкулезного микобактериоза и нуждаются в обследовании на наличие нетуберкулезных микобактерий.</p></trans-abstract><kwd-group xml:lang="en"><kwd>nontuberculous mycobacterial pulmonary disease</kwd><kwd>diagnosis</kwd><kwd>nontuberculous mycobacteria</kwd><kwd>computed tomography</kwd><kwd>case report</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>нетуберкулезный микобактериоз легких</kwd><kwd>диагностика</kwd><kwd>нетуберкулезные микобактерии</kwd><kwd>компьютерная томография</kwd><kwd>клинический случай</kwd></kwd-group><funding-group/></article-meta><fn-group/></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Izumi K, Morimoto K, Hasegawa N, Uchimura K, Kawatsu L, Ato M, Mitarai S. Epidemiology of adults and children treated for nontuberculous mycobacterial pulmonary disease in Japan. 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