RUDN Journal of MedicineRUDN Journal of MedicineВестник Российского университета дружбы народов. Серия: Медицина2313-02452313-0261Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)4608710.22363/2313-0245-2025-29-3-321-334POWVSYONCOLOGYОНКОЛОГИЯResearch ArticleElemental homeostasis in children and adolescents after completion of antitumor therapy for malignant neoplasmsЭлементный гомеостаз у детей и подростков после завершения противоопухолевой терапии злокачественных новообразованийhttps://orcid.org/0000-0002-6899-71058225-6360ZhukovskayaElena V.ЖуковскаяЕ. В.lobaeva.t@yandex.ruhttps://orcid.org/0000-0002-5677-11419151-0950LobaevaTatiana A.ЛобаеваТ. А.lobaeva.t@yandex.ruhttps://orcid.org/0000-0003-4664-5616KarelinAlexander F.КарелинА. Ф.lobaeva.t@yandex.ruhttps://orcid.org/0000-0002-1373-63547764-6486KorobeynikovaTatiana V.КоробейниковаТ. В.lobaeva.t@yandex.ruhttps://orcid.org/0000-0002-1643-59602227-6305RumyantsevAlexander G.РумянцевА. Г.lobaeva.t@yandex.ruhttps://orcid.org/0000-0001-7838-13665231-9017SkalnyAnatoly V.СкальныйА. В.lobaeva.t@yandex.ruDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologyНаучный центр медицины и реабилитации «Русское поле», Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия РогачеваRUDN UniversityРоссийский университет дружбы народовMGIMO-MED Medical UniversityМедицинский университет МГИМО-МЕДFirst Moscow State Medical University (Sechenov University)Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский университет)25092025293ONCOLOGYОНКОЛОГИЯ32133425092025Copyright ©; 2025, Zhukovskaya E.V., Lobaeva T.A., Karelin A.F., Korobeynikova T.V., Rumyantsev A.G., Skalny A.V.Copyright ©; 2025, Жуковская Е.В., Лобаева Т.А., Карелин А.Ф., Коробейникова Т.В., Румянцев А.Г., Скальный А.В.2025Zhukovskaya E.V., Lobaeva T.A., Karelin A.F., Korobeynikova T.V., Rumyantsev A.G., Skalny A.V.Жуковская Е.В., Лобаева Т.А., Карелин А.Ф., Коробейникова Т.В., Румянцев А.Г., Скальный А.В.https://creativecommons.org/licenses/by-nc/4.0https://journals.rudn.ru/medicine/article/view/46087

Relevance. As medical research develops, more and more attention is being paid to the study of elemental changes in cancer patients not only as a marker of the disease, but also as a possible complication of the disease. The aim was to study changes in the level of essential and toxic trace elements in patients who have undergone antitumor therapy (AT) for malignant neoplasms (MN). Materials and Methods. As part of a retrospective monocenter study, a group of 214 patients from the Russian Field Medical and Rehabilitation Research Center aged 4 to 17 years was formed. All patients were in remission after the completion of antitumor treatment: 107 patients with hemoblastosis and 107 with solid tumors. The age of the participants ranged from 4.2 to 17.6 years, with an average age of 11.4 years. For a comprehensive assessment of the elemental status in children, hair and blood serum were used, measurements were carried out by mass spectrometry after mineralization of the samples. Results and Discussion. The results of the study of hair samples and blood serum showed that the elemental profile of patients after AT has both similar patterns and distinctive features depending on the histological type of tumor. Conclusions. Patients with solid tumors had a higher accumulation of toxic metals compared to samples taken from patients with tumors of the hematopoiesis organs. Nevertheless, no serious specific changes in elemental homeostasis were observed depending on the histological structure. The results obtained emphasize the importance of careful monitoring of homeostasis parameters to prevent the development of complications of antitumor therapy associated with elemental homeostasis.

Актуальность. По мере развития медицинских исследований все больше внимания уделяется изучению элементных изменений у онкологических больных не только как маркера заболевания, но и как возможного осложнения заболевания. Целью данного исследования является изучение изменений уровня эссенциальных и токсичных микроэлементов у пациентов, прошедших противоопухолевую терапию (ПОТ) по поводу злокачественных новообразований (ЗНО). Материалы и методы. В рамках проведения ретроспективного моноцентрового исследования была сформировано группа из 214 пациентов лечебно-­реабилитационного научного центра “Русское поле” в возрасте от 4 до 17 лет. Все пациенты находились в состоянии ремиссии после завершения противоопухолевого лечения: 107 человек — по поводу гемобластозов и 107 — солидных опухолей. Возраст участников составлял от 4,2 до 17,6 лет, средний возраст — 11,4 года. Для комплексной оценки элементного статуса у детей использованы биосубстраты (волосы и сыворотка крови), измерения проводили методом масс-спектрометрии после минерализации образцов. Результаты и обсуждение. Результаты исследования образцов волос и сыворотки крови показали, что элементный профиль пациентов после ПОТ имеет как сходные закономерности, так и отличительные особенности в зависимости от гистологического типа опухоли. Выводы. Наши данные показывают, что у пациентов с солидными опухолями наблюдалось более высокое накопление токсичных металлов по сравнению с образцами, взятыми у пациентов с опухолями органов кроветворения. Тем не менее, серьезных специфических изменений элементного гомеостаза в зависимости от гистологической структуры не наблюдалось. Полученные результаты подчеркивают важность тщательного мониторинга параметров гомеостаза для предотвращения развития осложнений противоопухолевой терапии, связанных с элементным гомеостазом.

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