<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">45192</article-id><article-id pub-id-type="doi">10.22363/2313-0245-2025-29-2-177-189</article-id><article-id pub-id-type="edn">UDEHVH</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CARDIOLOGY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КАРДИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Speckle tracking echocardiography in patients with diabetes mellitus: a systematic review</article-title><trans-title-group xml:lang="ru"><trans-title>Возможность использования методики спекл-трекинг при проведении эхокардиографии у пациентов с сахарным диабетом: систематический обзор</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3086-067X</contrib-id><contrib-id contrib-id-type="spin">2437-7054</contrib-id><name-alternatives><name xml:lang="en"><surname>Abdujabborov</surname><given-names>Khurshed M.</given-names></name><name xml:lang="ru"><surname>Абдужабборов</surname><given-names>Х. М.</given-names></name></name-alternatives><email>1142230152@pfur.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-6210-0310</contrib-id><contrib-id contrib-id-type="spin">6310-9986</contrib-id><name-alternatives><name xml:lang="en"><surname>Ammar</surname><given-names>Rakan D.</given-names></name><name xml:lang="ru"><surname>Аммар</surname><given-names>Р. Д.</given-names></name></name-alternatives><email>1142230152@pfur.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-0656-2239</contrib-id><contrib-id contrib-id-type="spin">6978-5518</contrib-id><name-alternatives><name xml:lang="en"><surname>Tereshenko</surname><given-names>Ekaterina A.</given-names></name><name xml:lang="ru"><surname>Терещенко</surname><given-names>Е. А.</given-names></name></name-alternatives><email>1142230152@pfur.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5873-1768</contrib-id><contrib-id contrib-id-type="spin">9828-5409</contrib-id><name-alternatives><name xml:lang="en"><surname>Kobalava</surname><given-names>Zhanna D.</given-names></name><name xml:lang="ru"><surname>Кобалава</surname><given-names>Ж. Д.</given-names></name></name-alternatives><email>1142230152@pfur.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">RUDN University</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов имени Патриса Лумумбы</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-06-28" publication-format="electronic"><day>28</day><month>06</month><year>2025</year></pub-date><volume>29</volume><issue>2</issue><issue-title xml:lang="en">CARDIOLOGY</issue-title><issue-title xml:lang="ru">КАРДИОЛОГИЯ</issue-title><fpage>177</fpage><lpage>189</lpage><history><date date-type="received" iso-8601-date="2025-07-22"><day>22</day><month>07</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Abdujabborov K.M., Ammar R.D., Tereshenko E.A., Kobalava Z.D.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Абдужабборов Х.М., Аммар Р.Д., Терещенко Е.А., Кобалава Ж.Д.</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Abdujabborov K.M., Ammar R.D., Tereshenko E.A., Kobalava Z.D.</copyright-holder><copyright-holder xml:lang="ru">Абдужабборов Х.М., Аммар Р.Д., Терещенко Е.А., Кобалава Ж.Д.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/45192">https://journals.rudn.ru/medicine/article/view/45192</self-uri><abstract xml:lang="en"><p> Relevance Speckle tracking echocardiography (STE) constitutes a notable progression in the realm of non-invasive cardiac imaging, facilitating accurate quantification of myocardial deformation across various planes. This modality surpasses traditional echocardiographic metrics, such as left ventricular ejection fraction (LVEF), by allowing for the early identification of subclinical myocardial dysfunction. This review delineates the foundational principles and technological advancements associated with STE, encompassing the incorporation of deep learning algorithms, high-frame-rate imaging, and three-­dimensional applications that enhance tracking precision and clinical applicability. Particular attention is directed toward the significance of global longitudinal strain (GLS) as a sensitive biomarker indicative of early systolic impairment. The clinical significance of STE is particularly pronounced in individuals with type 1 diabetes mellitus (T1DM), a cohort that is at an increased risk for the onset of cardiovascular complications. Numerous studies illustrate that STE can detect myocardial strain abnormalities in diabetic patients well in advance of the appearance of overt cardiac symptoms or declines in LVEF. This capability facilitates the earlier recognition of diabetic cardiomyopathy, enhances the monitoring of therapeutic responses, and permits risk stratification based on parameters such as GLS and atrial strain. Conclusion: STE has emerged as an invaluable instrument in contemporary cardiology, particularly for the diabetic demographic, where it unveils subtle myocardial dysfunction frequently overlooked by conventional methods. Its expanding role in cardio-­oncology, heart failure management, and diabetes care underscores the necessity for broader clinical integration. Nevertheless, additional prospective, outcome-­based studies are imperative to validate its prognostic significance and to effectively incorporate it into standard clinical practice. By bridging the divide between imaging and early intervention, STE presents promising trajectories for the enhancement of long-term cardiovascular outcomes.</p></abstract><trans-abstract xml:lang="ru"><p>Эхокардиография с отслеживанием спеклов, свидетельствует о заметном прогрессе в области неинвазивной визуализации сердца, облегчающей оценку деформации миокарда в различных пространственных плоскостях. Этот инновационный метод превосходит традиционные эхокардиографические показатели, такие как фракция выброса левого желудочка, и позволяет выявлять субклиническую дисфункцию миокарда на ранних стадиях. Особое внимание уделяется значению глобальной продольной деформации (GLS) как высокочувствительного биомаркера, указывающего на раннюю систолическую недостаточность, Клиническая значимость оценки субклинической дисфункции миокарда особенно выражена у лиц с сахарным диабетом 1 типа (СД1). Эта демографическая группа характеризуется повышенной склонностью к развитию сердечно-­сосудистых осложнений. Многочисленные исследования показывают, что STE позволяет выявлять аномалии деформации миокарда у пациентов с диабетом задолго до появления явных сердечных проявлений или снижения уровня ЛВЭФ. Это способствует своевременному выявлению диабетической кардиомиопатии, улучшает мониторинг терапевтических реакций и позволяет проводить стратификацию рисков на основе таких показателей, как уровень ГЛС и предсердное напряжение. <italic>Выводы</italic>: Спекл трекинг эхокардиография становится незаменимым инструментом в современной кардиологии, особенно для пациентов с диабетом, поскольку они позволяют выявить нюансы дисфункции миокарда, часто упускаемые из виду традиционными методами. Тем не менее, дополнительные проспективные исследования, ориентированные на результаты, необходимы для обоснования прогностической значимости препарата и его эффективного внедрения в стандартную клиническую практику.</p></trans-abstract><kwd-group xml:lang="en"><kwd>speckle tracking echocardiography (STE)</kwd><kwd>global longitudinal strain (GLS)</kwd><kwd>myocardial deformation</kwd><kwd>diabetes mellitus</kwd><kwd>subclinical cardiac dysfunction</kwd><kwd>diabetic cardiomyopathy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>спэкл трэкинг эхокардиография</kwd><kwd>глобальная продольная деформация миокарда</kwd><kwd>диабетическая кардиомиопатия</kwd><kwd>субклиническая дисфункция миокарда</kwd></kwd-group><funding-group/></article-meta><fn-group/></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Karageorgos GM, Liang P, Mobadersany N, Gami P, Konofagou EE. Unsupervised deep learning-­based displacement estimation for vascular elasticity imaging applications. Phys. Med. Biol. 2023;68(15):10.1088/1361—6560/ace0f0. doi:10.1088/1361-6560/ace0f0</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Rebholz B, Zheng F, Almekkawy M. Two-dimensional iterative projection method for subsample speckle tracking of ultrasound images. Med. Biol. Eng. Comput. 2020;58(12):2937—2951. doi:10.1007/s11517-020-02264 z</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Yingchoncharoen T, Agarwal S, Popović ZB, Marwick TH. Normal ranges of left ventricular strain: a meta-analysis. J. Am. Soc. Echocardiogr. 2013;26(2):185—191. doi:10.1016/j.echo.2012.10.008</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Zhou SK, Greenspan H, Davatzikos C, Duncan JS, van Ginneken B, Madabhushi A, Prince JL, Rueckert D. A review of deep learning in medical imaging: Imaging traits, technology trends, case studies with progress highlights, and future promises. Proc. IEEE Inst. Elect.r Electron Eng. 2021;109(5):820—838. doi:10.1109/JPROC.2021.3054390</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Chen C, Qin C, Qiu H, Tarroni G, Duan J, Bai W, Rueckert, D. Deep Learning for Cardiac Image Segmentation: A Review. Front. Cardiovasc. Med. 2020;7:25. doi:10.3389/fcvm.2020.00025</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Painchaud N, Duchateau N, Bernard O, Jodoin PM. Echocardiography Segmentation with Enforced Temporal Consistency. IEEE transactions on medical imaging. 2022;41(10):2867—2878. doi.org/10.1109/TMI.2022.3173669</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Gao L, Lin Y, Ji M. Clinical Utility of Three-­Dimensional Speckle-­Tracking Echocardiography in Heart Failure. J. Clin. Med. 2022;11(21):6307. doi:10.3390/jcm11216307</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS, American Heart Association Writing Group on Myocardial Segmentation and Registration for Cardiac Imaging. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002;105(4):539—542. doi.org/10.1161/hc0402.102975</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Gherbesi E, Gianstefani S, Angeli F. Myocardial strain of the left ventricle by speckle tracking echocardiography: From physics to clinical practice. Echocardiography. 2024;41(1): e15753. doi:10.1111/echo.15753</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Kouris NT, Kostopoulos VS, Psarrou GA, Kostakou PM, Tzavara C, Olympios CD. Left ventricular ejection fraction and Global Longitudinal Strain variability between methodology and experience. Echocardiography. 2021;38(4):582—589. doi:10.1111/echo.15025</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Wang T, Li L, Huang J, Fan L. Assessment of subclinical left ventricle myocardial dysfunction using global myocardial work in type 2 diabetes mellitus patients with preserved left ventricle ejection fraction. Diabetol Metab Syndr. 2022;14(1):17. doi:10.1186/s13098-021-00781 x</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Karlsen S, Dahlslett T, Grenne B. Global longitudinal strain is a more reproducible measure of left ventricular function than ejection fraction regardless of echocardiographic training. Cardiovasc Ultrasound. 2019;17(1):18. doi:10.1186/s12947 019 0168 9</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Herrmann J, Lenihan D, Armenian S, Barac A, Blaes A, Cardinale D, Carver J, Dent S, Ky B, Lyon A R, López-­Fernández T, Fradley MG, Ganatra S, Curigliano G, Mitchell JD, Minotti G, Lang NN, Liu JE, Neilan TG, Nohria A, Valent P. (2022). Defining cardiovascular toxicities of cancer therapies: an International Cardio-­Oncology Society (IC-OS) consensus statement, European Heart Journal. 2022;43(4);280—299. doi.org/10.1093/eurheartj/ehab674</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Postadzhiyan A, Andreeva L, Tochev S, Finkov B. Impact of diabetes mellitus on arterial stiffness, and pulsatile hemodynamics in heart failure with preserved ejection fraction. Journal of Hypertension. 2023;41(Suppl 3): p e172. doi: 10.1097/01.hjh.0000940632.72210.08</mixed-citation></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">Zharikova ЕS, Villevalde SV, Kobalava ZD. Predictors of adverse left ventricular remodeling in patients after myocardial infarction RUDN Journal of Medicine. 2017;21(2):219—226 doi: 10.22363/231302452017212219226 (In Russian).</mixed-citation><mixed-citation xml:lang="ru">Е.С. Жарикова, С.В. Виллевальде, Ж.Д. Кобалава. Предикторы неблагоприятного ремоделирования левого желудочка у пациентов, перенесших инфаркт миокарда // Вестник РУДН. Серия: Медицина. 2017. Т. 21. № 2. C. 219—226.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><mixed-citation>Abou R, van der Bijl P, Bax JJ, Delgado V. Global longitudinal strain: clinical use and prognostic implications in contemporary practice. Heart. 2020;106(18):1438—1444. doi:10.1136/heartjnl 2019—316215</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Beautlin A, Govindaraj A, Durgadevi, Uma Maheswari, Yamini «Correlation between diastolic dysfunction and global longitudinal strain imaging in patients with diabetes mellitus.» Biomedicine: 2023;43(1):488—491. doi: 10.51248/.v43i01.2378</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Zhu J, Li W, Chen F, Xie Z, Zhuo K, Huang R. Impact of glycemic control on biventricular function in patients with type 2 diabetes mellitus: a cardiac magnetic resonance tissue tracking study. Insights Imaging. 2023;14(1):7. doi:10.1186/s13244 022 01357 7</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Siripuram C, Mahendran KB, Hegde SV, Murali Krishna S, Suresh Suvarna S, Kandimalla R. Role of Echocardiography in Detecting Left Ventricular Dysfunction Among Diabetic Patients: A Clinical and Biochemical Perspective. Cureus. 2025;17(2): e78720. doi:10.7759/cureus.78720</mixed-citation></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">Utina TG, Akasheva DU, Korsunsky DV, Drapkina OM. Significance of standard and speckle-­tracking echocardiography for early diagnosis of asymptomatic left ventricular dysfunction in type 2 diabetes. Cardiovascular Therapy and Prevention. 2023;22(1):3478. doi.org/10.15829/1728 8800 2023 3478. (In Russian).</mixed-citation><mixed-citation xml:lang="ru">Утина Т.Г., Акашева Д.У., Корсунский Д.В., Драпкина О.М. Значение стандартной и спекл-­трекинговой эхокардиографии для ранней диагностики бессимптомной дисфункции миокарда левого желудочка при сахарном диабете 2 типа // Кардиоваскулярная терапия и профилактика. 2023. 22(1). 3478.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><mixed-citation>Lehner LJ, Haag K, Zhang K. Speckle tracking analysis of left ventricular function in patients with type 1 diabetes mellitus and kidney failure, European Heart Journal — Cardiovascular Imaging. 2022;23(Suppl.1): jeab289.060, https://doi.org/10.1093/ehjci/jeab289.060</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Ifuku M, Takahashi K, Hosono Y, Iso T, Ishikawa A, Haruna H, Takubo N, Komiya K, Kurita M, Ikeda F, Watada H, Shimizu T. Left atrial dysfunction and stiffness in pediatric and adult patients with Type 1 diabetes mellitus assessed with speckle tracking echocardiography. Pediatric Diabetes. 2021;22:303—319. doi: 10.1111/PEDI.13141</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Jensen MT, Sogaard P, Andersen HU, Bech J, Fritz Hansen T, Biering-­Sørensen T, Jørgensen PG, Galatius S, Madsen JK, Rossing P, Jensen JS. Global longitudinal strain is not impaired in type 1 diabetes patients without albuminuria: the Thousand &amp; 1 study. JACC Cardiovasc Imaging. 2015;8(4):400—410. doi: 10.1016/j.jcmg.2014.12.020</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Berceanu M, Mirea O, Târtea GC, Donoiu I, Militaru C, Istrătoaie O, Săftoiu A. The Significance of Right Ventricle in Young Subjects with Diabetes Mellitus Type 1. An echocardiographyic study. Current health sciences journal. 2019;45:174—178. doi: 10.12865/CHSJ.45.02.07</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Nemes A, Piros GÁ, Lengyel C, Domsik P, Kalapos A, Várkonyi TT, Orosz A, Forster T. «Complex evaluation of left atrial dysfunction in patients with type 1 diabetes mellitus by three-­dimensional speckle tracking echocardiography: results from the MAGYAR-Path Study.» Anatolian Journal of Cardiology. 2015;16:587—593. doi: 10.5152/ANATOLJCARDIOL.2015.6225</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Fridolfsson C, Thegerström J, Åkesson K. Lower left atrial function in young individuals with type 1 diabetes mellitus compared to healthy controls: an echocardiographic study. Sci. Rep. 2024;14:3982.doi.org/10.1038/s41598 024 54597 6</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Ahmed T, Hassan MN, Mazen AA, Hegazy SA. Detection of early left ventricular and left atrial dysfunction in type I diabetes mellitus using two dimensional speckle tracking echocardiography. The Scientific Journal of Al-­Azhar Medical Faculty, Girls. 2018;2:106—114.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Berceanu M, Mirea O, Donoiu I, Militaru C, Săftoiu A, Istrătoaie O. Myocardial Function Assessed by Multi-­Layered Two-­Dimensional Speckle Tracking Analysis in Asymptomatic Young Subjects with Diabetes Mellitus Type 1. Cardiology. 2020;145(2):80—87. doi: 10.1159/000504532</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Jędrzejewska I, Król W, Światowiec A, Wilczewska A, Grzywanowska-­Łaniewska I, Dłużniewski M, Braksator W. Left and right ventricular systolic function impairment in type 1 diabetic young adults assessed by 2D speckle tracking echocardiography. Eur Heart J Cardiovasc Imaging. 2016;17(4):438—46. doi: 10.1093/ehjci/jev164</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Bogdanović J, Ašanin M, Krljanac G, Lalić NM, Jotić A, Stanković S, Rajković N, Stošić L, Rasulić I, Milin J, Popović D, Bogdanović L, Lalić K. Impact of acute hyperglycemia on layer-­specific left ventricular strain in asymptomatic diabetic patients: an analysis based on two-dimensional speckle tracking echocardiography. Cardiovasc Diabetol. 2019;18(1):68. doi: 10.1186/s12933 019 0876 3</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Hajdu M, Knutsen MO, Vértes V, Vorobcsuk-­Varga N, Molnár G, Wittmann I, Faludi R. Quality of glycemic control has significant impact on myocardial mechanics in type 1 diabetes mellitus. Sci Rep. 2022;12:20180 doi.org/10.1038/s41598 022 24619 2</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Abdel-­Salam Z, Khalifa M, Ayoub A, Hamdy A, Nammas W. Early changes in longitudinal deformation indices in young asymptomatic patients with type 1 diabetes mellitus: assessment by speckle-­tracking echocardiography. Minerva Cardioangiol. 2016;64(2):138—144.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Ringle A, Dornhorst A, Rehman MB, Ruisanchez C, Nihoyannopoulos P. Evolution of subclinical myocardial dysfunction detected by two-dimensional and three-­dimensional speckle tracking in asymptomatic type 1 diabetic patients: a longterm follow-up study. Echo Research and Practice. 2017;4(4):73—81. doi.org/10.1530/ERP 17-0052</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Li Z, Qian Y, Fan CY, Huang Y. Application of three-­dimensional speckle tracking technique in measuring left ventricular myocardial function in patients with diabetes. World J. Diabetes. 2024;15(4):783—792. doi: 10.4239/wjd.v15.i4.783</mixed-citation></ref></ref-list></back></article>
