<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">42016</article-id><article-id pub-id-type="doi">10.22363/2313-0245-2024-28-4-548-559</article-id><article-id pub-id-type="edn">HHATKB</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>GINECOLOGY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Risk factors for recurrence of vulvovaginal infections</article-title><trans-title-group xml:lang="ru"><trans-title>Факторы риска рецидивирования вульво-вагинальных инфекций</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6537-2572</contrib-id><contrib-id contrib-id-type="spin">3707-3561</contrib-id><name-alternatives><name xml:lang="en"><surname>Kolesnikova</surname><given-names>Ekaterina V.</given-names></name><name xml:lang="ru"><surname>Колесникова</surname><given-names>Е. В.</given-names></name></name-alternatives><email>milka82@list.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-0257-6732</contrib-id><name-alternatives><name xml:lang="en"><surname>Osipova</surname><given-names>Lyudmila K.</given-names></name><name xml:lang="ru"><surname>Осипова</surname><given-names>Л. К.</given-names></name></name-alternatives><email>milka82@list.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5460-5959</contrib-id><contrib-id contrib-id-type="spin">5292-3261</contrib-id><name-alternatives><name xml:lang="en"><surname>Zharov</surname><given-names>Alexander V.</given-names></name><name xml:lang="ru"><surname>Жаров</surname><given-names>А. В.</given-names></name></name-alternatives><email>milka82@list.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kuban State Medical University</institution></aff><aff><institution xml:lang="ru">Кубанский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Regional Clinical Hospital No. 2</institution></aff><aff><institution xml:lang="ru">Краевая клиническая больница № 2</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2024</year></pub-date><volume>28</volume><issue>4</issue><issue-title xml:lang="en">ONCOLOGY</issue-title><issue-title xml:lang="ru">ОНКОЛОГИЯ</issue-title><fpage>548</fpage><lpage>559</lpage><history><date date-type="received" iso-8601-date="2024-12-16"><day>16</day><month>12</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Kolesnikova E.V., Osipova L.K., Zharov A.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Колесникова Е.В., Осипова Л.К., Жаров А.В.</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Kolesnikova E.V., Osipova L.K., Zharov A.V.</copyright-holder><copyright-holder xml:lang="ru">Колесникова Е.В., Осипова Л.К., Жаров А.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/42016">https://journals.rudn.ru/medicine/article/view/42016</self-uri><abstract xml:lang="en"><p><italic>Relevance. </italic>Currently, inflammatory and non-inflammatory infections of the lower urogenital tract are a serious medical problem and are one of the main reasons for seeking medical help from gynecologists. These infections account for a significant share (from 55 to 80 %) of diseases of the reproductive system. The most common symptoms of vulvovaginal infections (VVI) are discomfort in the genitals, discharge, itching, superficial dyspareunia and unpleasant odor. In addition to the main clinical signs of inflammation, there may be the symptoms of vaginal dysbiosis that occurs without obvious signs of inflammation. Thus, VVI is manifested by a wide range of clinical symptoms and is a collective term for several nosological entities. <italic>Conclusion.</italic> Despite the existence of various methods for diagnosing and treating VVI, the problem of recurrent vulvovaginal infections, which can lead to various pathological conditions both in the reproductive system and in the psychoemotional and sexual sphere of patients, remains extremely relevant and complex. These diseases require timely detection and effective treatment. Therefore, scientific research aimed at identifying the causes (risk factors) of relapse of the disease is becoming especially relevant today. However, even with the exclusion of general risk factors, the exacerbation of vaginal dysbiosis in patients is often impossible to prevent.</p></abstract><trans-abstract xml:lang="ru"><p><italic>Актуальность</italic>. На сегодняшний день воспалительные и невоспалительные инфекции нижних отделов урогенитального тракта представляют серьезную медицинскую проблему и являются одной из ведущих причин обращения за медицинской помощью к гинекологам. Эти инфекции составляют значительную долю (от 55 до 80 %) среди заболеваний репродуктивной системы. Наиболее часто встречающимися симптомами вульво-­вагинальных инфекций (ВВИ) являются дискомфорт в области половых органов, выделения, зуд, поверхностная диспареуния и неприятный запах. Кроме основных клинических признаков воспаления при ВВИ может присутствовать картина дисбиоза влагалища, протекающая без явных признаков воспаления. Таким образом, ВВИ проявляются широким спектром клинических симптомов и являются собирательным понятием нескольких нозологических единиц. <italic>Выводы.</italic> Несмотря на существование большого количества методов диагностики и лечения ВВИ крайне актуальной и сложной остается проблема рецидивирующих вульво-­вагинальных инфекций, которые могут приводить к различным патологическим состояниям как в репродуктивной системе, так и в психоэмоциональной и сексуальной сфере пациенток. Эти состояния требуют своевременного выявления и эффективного лечения. Поэтому особую актуальность сегодня приобретает научный поиск, направленный на выявление причин (факторов риска) рецидивирования заболевания. Однако даже при исключении распространенных факторов риска часто не удается предотвратить обострение дисбиоза влагалища у пациенток.</p></trans-abstract><kwd-group xml:lang="en"><kwd>vaginal dysbiosis</kwd><kwd>recurrent vaginal dysbiosis</kwd><kwd>vaginal dysbiosis and vitamin D</kwd><kwd>folic acid</kwd><kwd>iron</kwd><kwd>vitamin D</kwd><kwd>folic acid</kwd><kwd>iron and innate immunity</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>дисбиоз влагалища</kwd><kwd>рецидивирующий дисбиоз влагалища</kwd><kwd>дисбиоз влагалища и витамин Д</kwd><kwd>фолиевая кислота</kwd><kwd>железо</kwd><kwd>витамин Д</kwd><kwd>фолиевая кислота</kwd><kwd>железо и врожденный иммунитет</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Strelec IO, Grechkanev GO. Experience of successful combination therapy of frequently recurrent bacterial vaginosis. Medical almanac. 2021;3(68): 66—69 (In Russ.) [Стрелец И.О., Гречканев Г.О. Опыт успешной комбинированной терапии часто рецидивирующего бактериального вагиноза. Медицинский альманах. 2021;3(68): 66—69.]</mixed-citation></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Bebneva TN, Dyshkovets AA. Vaginal dysbiosis is an interdisciplinary issue. Perspectives from a gynecologist and immunologist. Methods, options, and prospects for addressing. Russian Journal of Woman and Child Health. 2020;3(3): 157—162 (In Russian) doi: 10.32364/2618-8430-2020-3-3-157-162</mixed-citation><mixed-citation xml:lang="ru">Бебнева Т.Н., Дышковец А.А. Дисбиоз влагалища как междисциплинарная проблема. Взгляд с позиций гинеколога и иммунолога. Методы, пути и перспективы решения. РМЖ. Мать и дитя. 2020;3(3):157—162 doi: 10.32364/2618-8430-2020-3-3-157-162</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><mixed-citation>Thomas-­White K, Navarro P, Wever F, King L, Dillard LR, Krapf J. Psychosocial impact of recurrent urogenital infections: a review. Womens Health (Lond). 2023;19:17455057231216537. doi: 10.1177/17455057231216537</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Osipova LK, Kolesnikova EV, Zharov AV, Penzhoyan МA. Obstetric, somatic and infectious risk factors for vulvar lichen sclerosus. RUDN Journal of Medicine. 2024;28(1):86—103. [Осипова Л.К., Колесникова Е.В., Жаров А.В., Пенжоян М.А. Акушерские, соматические и инфекционные факторы риска склеротического лихена вульвы. Вестник Российского университета дружбы народов. Серия: Медицина. 2024;28(1):86—103.] doi: 10.22363/2313-0245-2024-28-1-86-103</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Mulinganya G, De Vulder A, Bisimwa G, Boelens J, Claeys G, De Keyser K, De Vos D, Hendwa E, Kampara F, Kujirakwinja Y, Mongane J, Mubalama I, Vaneechoutte M, Callens S, Cools P. Prevalence, risk factors and adverse pregnancy outcomes of second trimester bacterial vaginosis among pregnant women in Bukavu, Democratic Republic of the Congo. PLoS One. 2021;25;16(10): e0257939. doi: 10.1371/journal.pone.0257939</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Abramashvili YuG, Kolesnikova NV, Borisova OYu, Guryanova SV. Low molecular weight bioregulator of bacterial origin in condylomatosis therapy optimization. RUDN Journal of Medicine. 2020;24(2):163—167. doi: 10.22363/2313-0245-2020-24-2-163-167</mixed-citation></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Kozlova AA, Nikolaeva AV, Priputnevich TV, Baranov II, Meshalkina IV. Vaginal microbiome in women during pregnancy and postpartum period: dynamics, its link with the intestinal microflora and its influence on microbiota formation in newborns. Obstetrics and Gynecology: News, Opinions, Training. 2021;9(4):71—8. (In Russian) doi: https://doi.org/10.33029/2303-9698-2021-9-4-71-78</mixed-citation><mixed-citation xml:lang="ru">Козлова А.А., Николаева А.В., Припутневич Т.В., Баранов И.И., Мешалкина И.В. Микробиом влагалища женщины во время беременности и в послеродовом периоде: динамика, взаимосвязь с кишечной микрофлорой, влияние на становление микробиоты новорожденного. Акушерство и гинекология: новости, мнения, обучение. 2021;9(4):71—78. doi: https://doi.org/10.33029/2303-9698-2021-9-4-71-78</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">Kolesnikova EV, Zharov AV, Osipova LK, Dupleev AI. Predicting the development of vulvar lichen sclerosus. RUDN Journal of Medicine. 2024;28(1):76—85. (In Russian).  doi: 10.22363/2313-0245-2024-28-1-76-85</mixed-citation><mixed-citation xml:lang="ru">Колесникова Е.В., Жаров А.В., Осипова Л.К., Дуплеев А.И. Прогнозирование развития склеротического лихена вульвы. Вестник Российского университета дружбы народов. Серия: Медицина. 2024;28(1):76—85. doi: 10.22363/2313-0245-2024-28-1-76-85</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><mixed-citation>Verwijs MC, Agaba SK, Darby AC, van de Wijgert JHHM. Impact of oral metronidazole treatment on the vaginal microbiota and correlates of treatment failure. Am J Obstet Gynecol. 2020;222(2):157.e1—157.e13. doi: 10.1016/j.ajog.2019.08.008</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Vodstrcil LA, Muzny CA, Plummer EL, Sobel JD, Bradshaw CS. Bacterial vaginosis: drivers of recurrence and challenges and opportunities in partner treatment. BMC Med. 2021;19(1):194. doi: 10.1186/s12916-021-02077-3</mixed-citation></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">Dikke GB. Bacterial vaginosis: novel aspects of etiology, pathogenesis, and selection of therapeutic strategy. Russian Journal of Woman and Child Health. 2019;2(4):307—313 (In Russian) doi: 10.32364/2618-8430-2019-2-4-307-313</mixed-citation><mixed-citation xml:lang="ru">Дикке Г.Б. Бактериальный вагиноз: новые аспекты этиопатогенеза и выбора терапевтических стратегий. РМЖ. Мать и дитя. 2019;2(4):307—313. doi: 10.32364/2618-8430-2019-2-4-307-313</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><mixed-citation>Ma X, Wu M, Wang C, Li H, Fan A, Wang Y, Han C, Xue F. The pathogenesis of prevalent aerobic bacteria in aerobic vaginitis and adverse pregnancy outcomes: a narrative review. Reprod Health. 2022;19(1):21. doi: 10.1186/s12978-021-01292-8</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Barrientos-­Durán A, Fuentes-­López A, de Salazar A, Plaza-­Díaz J, García F. Reviewing the Composition of Vaginal Microbiota: Inclusion of Nutrition and Probiotic Factors in the Maintenance of Eubiosis. Nutrients. 2020;12(2):419. doi: 10.3390/nu12020419</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Cooke G, Watson C, Deckx L, Pirotta M, Smith J, van Driel ML. Treatment for recurrent vulvovaginal candidiasis (thrush). Cochrane Database Syst Rev. 2022;1(1): CD009151. doi: 10.1002/14651858.CD009151.pub2</mixed-citation></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">Ivanova EA, Radzinsky VE, Makarov AV. Recurrent bacterial vaginosis: etiology, pathogenesis, diagnosis, treatment.  M.: “GEOTAR-Media”, 2018. 256 p. (In Russian).</mixed-citation><mixed-citation xml:lang="ru">Иванова Е.А., Радзинский В.Е., Макаров А.В. Рецидивирующие бактериальные вагинозы: этиология, патогенез, диагностика, лечение. М.: «ГЭОТАР-Медиа», 2018. 256 с.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><mixed-citation>Lokken EM, Balkus JE, Kiarie J, Hughes JP, Jaoko W, Totten PA, McClelland RS, Manhart LE. Association of Recent Bacterial Vaginosis With Acquisition of Mycoplasma genitalium. Am J Epidemiol. 2017;186(2):194—201.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Tamarelle J, Thiébaut ACM, de Barbeyrac B, Bébéar C, Ravel J, Delarocque-­Astagneau E. The vaginal microbiota and its association with human papillomavirus, Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium infections: a systematic review and meta-analysis. Clin Microbiol Infect. 2019;25(1):35—47. doi: 10.1016/j.cmi.2018.04.019</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Norenhag J, Du J, Olovsson M, Verstraelen H, Engstrand L, Brusselaers N. The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta-analysis. BJOG. 2020;127(2):171—180. doi: 10.1111/1471-0528.15854</mixed-citation></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">Kira EF, Yatsyshina SA, Dyakonov SA. Microbial secrets. Status Praesens. Gynecology, obstetrics, infertile marriage. 2020;4(69):70—75. (In Russian).</mixed-citation><mixed-citation xml:lang="ru">Кира Е.Ф., Яцышина С.А., Дьяконов С.А. Микробные тайны. StatusPraesens. Гинекология, акушерство, бесплодный брак. 2020; 4(69):70—75.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><mixed-citation>Vodstrcil LA, Muzny CA, Plummer EL, Sobel JD, Bradshaw CS. Bacterial vaginosis: drivers of recurrence and challenges and opportunities in partner treatment. BMC Med. 2021;19(1):194. doi: 10.1186/s12916-021-02077-3</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Guryanova SV. Immunomodulation, Bioavailability and Safety of Bacteriocins. Life. 2023;13:1521. doi: https://doi.org/10.3390/life13071521</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Guryanova SV. Regulation of Immune Homeostasis via Muramyl Peptides-­Low Molecular Weight Bioregulators of Bacterial Origin. Microorganisms. 2022;10(8):1526. doi: https://doi.org/10.3390/microorganisms10081526</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Guryanova SV, Gigani OB, Gudima GO, Kataeva AM,  Kolesnikova NV. Dual Effect of Low Molecular Weight Bioregulators of Bacterial Origin in Experimental Model of Asthma. Life. 2022;12:192. doi: https://doi.org/10.3390/life12020192</mixed-citation></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">Nikolaeva AV, Kozlova AA, Baranov II, Priputnevich TV. Current understanding of the relationship between gut and vaginal microbiotas. Obstetrics and Gynecology. 2021;9:5—11. (In Russian). doi: 10.18565/aig.2021.9.5‑ll</mixed-citation><mixed-citation xml:lang="ru">Николаева А.В., Козлова А.А., Баранов И.И., Припутневич Т.В. Современные представления о взаимосвязи кишечной и вагинальной микробиот. Акушерство и гинекология. 2021;9:5—11. doi: 10.18565/aig.2021.9.5‑ll</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">Bezmenko AA, Sadovaya ND. Vaginal and intestinal microbiocenosis composition in pregnant women. Journal of obstetrics and women’s diseases. 2019; 68(6): 29—36. (In Russian). doi: 10.17816/JOWD68629-36</mixed-citation><mixed-citation xml:lang="ru">Безменко А.А., Садовая Н.Д. Состояние микробиоценозов влагалища и кишечника у беременных. Журнал акушерства и женских болезней. 2019; 68(6):29—36. doi: 10.17816/JOWD68629-36</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><mixed-citation>Salazar AS, Nogueira NF, Rodriguez VJ, Mantero A, Cherenack EM, Raccamarich P, Maddalon M, Brophy T, Montgomerie E, Klatt NR, Jones DL, Alcaide ML. A Syndemic Approach to Explore Factors Associated with Bacterial Vaginosis. AIDS Behav. 2022;26(9):3110—3118. doi: 10.1007/s10461-022-03634-4</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Nakama C, Thompson B, Szybala C, McBeth A, Dobner P, Zwickey H. The Continuum of Microbial Ecosystems along the Female Reproductive Tract: Implications for Health and Fertility. Pathogens. 2022;11(11):1244. doi: 10.3390/pathogens11111244</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Kolde R, Franzosa EA, Rahnavard G, Hall AB, Vlamakis H, Stevens C, Daly MJ, Xavier RJ, Huttenhower C. Host genetic variation and its microbiome interactions within the Human Microbiome Project. Genome Med. 2018;10(1):6. doi: 10.1186/s13073-018-0515-8</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Beamer MA, Austin MN, Avolia HA, Meyn LA, Bunge KE, Hillier SL. Bacterial species colonizing the vagina of healthy women are not associated with race. Anaerobe. 2017;45:40—43. doi: 10.1016/j.anaerobe.2017.02.020</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Mutli E, Mändar R, Koort K, Salumets A, Team EBR, Laisk T. Genome-wide association study in Estonia reveals importance of vaginal epithelium associated genes in case of recurrent vaginitis. J Reprod Immunol. 2024;162:104216. doi: 10.1016/j.jri.2024.104216</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Murphy K, Keller M, Anastos K. Impact of reproductive aging on the vaginal microbiome and soluble immune mediators in women living with and at-risk for HIV infection. PLoS ONE. 2019;14: e0216049. doi: https://doi.org/10.1371/journal.pone.0216049</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Bastianelli C, Farris M, Bianchi P. The effect of different contraceptive methods on the vaginal microbiome. Expert Review of Clinical Pharmacology. 2021;14(7):1—16. doi: https://doi.org/10.1080/17512433.2021.1917373</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Sobel JD, Kaur N, Woznicki NA, Boikov D, Aguin T, Gill G, Akins RA. Conventional oral and secondary high dose vaginal metronidazole therapy for recurrent bacterial vaginosis: clinical outcomes, impacts of sex and menses. Infect Drug Resist. 2019;12:2297—2307. doi: 10.2147/IDR.S213853</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Song SD, Acharya KD, Zhu JE, Deveney CM, Walther-­Antonio MRS, Tetel MJ, Chia N. Daily Vaginal Microbiota Fluctuations Associated with Natural Hormonal Cycle, Contraceptives, Diet, and Exercise. mSphere. 2020;5(4): e00593—20. doi: 10.1128/mSphere.00593-20</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Chen Y, Hong Z, Wang W, Gu L, Gao H, Qiu L, Di W. Association between the vaginal microbiome and high-risk human papillomavirus infection in pregnant Chinese women. BMC Infect Dis. 2019;19(1):677. doi:10.1186/s12879-019-4279-6</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Donders G, Bellen G, Janssens D, Van Bulck B. Hinoul P, Verguts J. Influence of contraceptive choice on vaginal bacterial and fungal microflora. Eur J Clin Microbiol Infect Dis. 2017;36(1):43—48. doi: 10.1007/s10096-016-2768-8</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Balle C, Konstantinus IN, Jaumdally SZ, Havyarimana E, Lennard K, Esra R, Barnabas SL, Happel AU, Moodie Z, Gill K, Pidwell T, Karaoz U, Brodie E, Maseko V, Gamieldien H, Bosinger SE, Myer L, Bekker LG, Passmore JS, Jaspan HB. Hormonal contraception alters vaginal microbiota and cytokines in South African adolescents in a randomized trial. Nat Commun. 2020;11(1):5578. doi: 10.1038/s41467-020-19382-9</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Jin C, Qin L, Liu Z, Li X, Gao X, Cao Y, Zhao S, Wang J, Han T, Yan L, Song J, Zhang F, Liu F, Zhang Y, Huang Y, Song Y, Liu Y, Yao Z, Chen H, Zhang Z, Zhao S, Feng Y, Zhang YN, Qian Y, Sun T, Feng Q, Zhao H. Comparative analysis of the vaginal microbiome of healthy and polycystic ovary syndrome women: a large cross-­sectional study. Reprod Biomed Online. 2023;46(6):1005—1016. doi: 10.1016/j.rbmo.2023.02.002</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Bitew A, Abebaw Y, Bekele D, Mihret A. Prevalence of Bacterial Vaginosis and Associated Risk Factors among Women Complaining of Genital Tract Infection. Int J Microbiol. 2017;2017:4919404. doi: 10.1155/2017/4919404</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Misselwitz B, Butter M. Verbeke K, Fox MR. Update on lactose malabsorption and intolerance: pathogenesis, diagnosis and clinical management. Gut. 2019;68:2080—2091. doi: 10.1136/gutjnl‑2019-318404</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Olson KM, Boohaker LJ, Schwebke JR, Aslibekyan S, Muzny CA. Comparisons of vaginal flora patterns among sexual behaviour groups of women: implications for the pathogenesis of bacterial vaginosis. Sex Health. 2018;15(1):61—67. doi: 10.1071/SH17087</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Nelson TM, Borgogna JC., Michalek RD., Roberts DW, Rath JM, Glover ED, Ravel J, Shardell MD, Yeoman CJ, Brotman RM. Cigarette smoking is associated with an altered vaginal tract metabolomic profile. Sci. Rep. 2018;8:852. doi: 0.1038/s41598-017-14943-3</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Amabebe E, Anumba DOC. Psychosocial stress, cortisol levels, and maintenance of vaginal health. Front. Endocrinol. 2018;9:568. doi: 10.3389/fendo.2018.00568</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Nansel TR, Riggs MA., Yu KF, Andrews WW, Schwebke JR, Klebanoff MA. The association of psychosocial stress and bacterial vaginosis in a longitudinal cohort. Am J Obstet Gynecol. 2006;194(2):381—6. doi: 10.1016/j.ajog.2005.07.047</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Tamarelle J, Creze M M, Savathdy V, Phonekeo S, Wallenborn J, Siengsounthone L, Fink G, Odermatt P, Kounnavong S, Sayasone S, Vonaesch P. Dynamics and consequences of nutrition-­related microbial dysbiosis in early life: study protocol of the VITERBI GUT project. Front Nutr. 2023;10:1111478. doi: 10.3389/fnut.2023.1111478</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Rosen EM, Martin CL, Siega-­Riz AM, Dole N, Basta PV, Serrano M, Fettweis J, Wu M, Sun S, Thorp JM, Jr, Buck G, Fodor AA., Engel SM. Is prenatal diet associated with the composition of the vaginal microbiome? Paediatr Perinat Epidemiol. 2022;36(2):243—253. doi: 10.1111/ppe.12830</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Dunlop AL, Jordan SL, Ferranti EP, Hill CC, Patel S, Hao L, Corwin EJ, Tangpricha V. Total and Free 25-Hydroxy-­Vitamin D and Bacterial Vaginosis in Pregnant African American Women. Infect Dis Obstet Gynecol. 2019;2019:9426795. doi: 10.1155/2019/9426795</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Mojtahedi SF, Mohammadzadeh A, Mohammadzadeh F, Jalili Shahri J, Bahri N. Association between bacterial vaginosis and 25-Hydroxy vitamin D: a case-control study. BMC Infect Dis. 2023;23(1):208. doi: 10.1186/s12879-023-08120-3</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Thoma ME, Klebanoff MA, Rovner AJ, Nansel TR, Neggers Y, Andrews WW, Schwebke JR. Bacterial vaginosis is associated with variation in dietary indices. J. Nutr. 2011;141:1698—1704. doi: 10.3945/jn.111.140541</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Kurowska K, Kobylińska M, Antosik K. Folic acid — importance for human health and its role in COVID‑19 therapy. Rocz Panstw Zakl Hig. 2023;74(2):131—141. doi: 10.32394/rpzh.2023.0252</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Uribe-­Diaz S, Nazeer N, Jaime J, Vargas-­Bermúdez DS. Yitbarek A, Ahmed M, Rodríguez-­Lecompte JC. Folic acid enhances proinflammatory and antiviral molecular pathways in chicken B-lymphocytes infected with a mild infectious bursal disease virus. Br Poult Sci. 2022;63(1):1—13. doi: 10.1080/00071668.2021.1958298</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Neggers YH, Nansel TR, Andrews WW, Schwebke JR, Yu KF, Goldenberg RL, Klebanoff MA. Dietary intake of selected nutrients affects bacterial vaginosis in women. J Nutr. 2007;137(9):2128—2133. doi: 10.1093/jn/137.9.2128</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Cui TT, Luo J, Deng RL, Yang YT, Yin YW, Chen XF, Chen HK, Liao WZ, Huang ZM, Deng XY, Guo XG. Negative associations between folate and bacterial vaginosis in the NHANES 2001 to 2004. BMC Infect Dis. 2023;23(1):483. doi: 10.1186/s12879-023-08318-5</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Golonka R, Yeoh BS, Vijay-­Kumar M. The Iron Tug-of-­War between Bacterial Siderophores and Innate Immunity. J Innate Immun. 2019;11(3):249—262. doi: 10.1159/000494627</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Yadav R, Noinaj N, Ostan N, Moraes T, Stoudenmire J, Maurakis S, Cornelissen C.N. Structural Basis for Evasion of Nutritional Immunity by the Pathogenic Neisseriae. Front Microbiol. 2020;10:2981. doi: 10.3389/fmicb.2019.02981</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Akinbosede D, Chizea R, Hare SA. Pirates of the haemoglobin. Microb Cell. 2022;9(4):84—102. doi: 10.15698/mic2022.04.775</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Zhang Y, Sen S, Giedroc DP. Iron Acquisition by Bacterial Pathogens: Beyond Tris-­Catecholate Complexes. Chembiochem. 2020;21(14):1955—1967. doi: 10.1002/cbic.201900778</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Perálvarez-­Marín A, Baranowski E, Bierge P, Pich OQ, Lebrette H. Metal utilization in genome-­reduced bacteria: Do human mycoplasmas rely on iron? Comput Struct Biotechnol J. 2021;19:5752—5761. doi: 10.1016/j.csbj.2021.10.022</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Soriano-­Lerma A, García-­Burgos M, Alférez MJM, Pérez-­Carrasco V, Sanchez-­Martin V, Linde-­Rodríguez Á, Ortiz-­González M, Soriano M, García-­Salcedo JA, López-­Aliaga I. Gut microbiome-­short-chain fatty acids interplay in the context of iron deficiency anaemia. Eur J Nutr. 2022;61(1):399—412. doi: 10.1007/s00394-021-02645-6</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Verstraelen H, Delanghe J, Roelens K, Blot S, Claeys G, Temmerman M. Subclinical iron deficiency is a strong predictor of bacterial vaginosis in early pregnancy. BMC Infect Dis. 2005;5:55. doi: 10.1186/1471-2334-5-55</mixed-citation></ref></ref-list></back></article>
