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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">42014</article-id><article-id pub-id-type="doi">10.22363/2313-0245-2024-28-4-508-536</article-id><article-id pub-id-type="edn">HAKGWK</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Stomatology</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Дантистика</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Alveolar clefts bone grafting: on the issue of modern treatment paradigm</article-title><trans-title-group xml:lang="ru"><trans-title>Костная пластика расщелин альвеолярного отростка: к вопросу о современной парадигме лечения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7254-4205</contrib-id><name-alternatives><name xml:lang="en"><surname>Kuznetsov</surname><given-names>Alexey M.</given-names></name><name xml:lang="ru"><surname>Кузнецов</surname><given-names>А. М.</given-names></name></name-alternatives><email>hannaimanova@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8335-8283</contrib-id><contrib-id contrib-id-type="spin">9492-9905</contrib-id><name-alternatives><name xml:lang="en"><surname>Imanova</surname><given-names>Khanna Z.</given-names></name><name xml:lang="ru"><surname>Иманова</surname><given-names>Х. З.</given-names></name></name-alternatives><email>hannaimanova@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6583-4685</contrib-id><contrib-id contrib-id-type="spin">4604-5103</contrib-id><name-alternatives><name xml:lang="en"><surname>Gusarov</surname><given-names>Artem M.</given-names></name><name xml:lang="ru"><surname>Гусаров</surname><given-names>А. М.</given-names></name></name-alternatives><email>hannaimanova@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-8599-115X</contrib-id><contrib-id contrib-id-type="spin">7120-8088</contrib-id><name-alternatives><name xml:lang="en"><surname>Yackevich</surname><given-names>Oleg S.</given-names></name><name xml:lang="ru"><surname>Яцкевич</surname><given-names>О. С.</given-names></name></name-alternatives><email>hannaimanova@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-0074-6389</contrib-id><contrib-id contrib-id-type="spin">4171-2542</contrib-id><name-alternatives><name xml:lang="en"><surname>Zorych</surname><given-names>Maryanna E.</given-names></name><name xml:lang="ru"><surname>Зорич</surname><given-names>М. Е.</given-names></name></name-alternatives><email>hannaimanova@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7812-1433</contrib-id><contrib-id contrib-id-type="spin">8709-8397</contrib-id><name-alternatives><name xml:lang="en"><surname>Korotkova</surname><given-names>Nadezhda L.</given-names></name><name xml:lang="ru"><surname>Короткова</surname><given-names>Н. Л.</given-names></name></name-alternatives><email>hannaimanova@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-3203-8985</contrib-id><name-alternatives><name xml:lang="en"><surname>Kopylova</surname><given-names>Ulyana O.</given-names></name><name xml:lang="ru"><surname>Копылова</surname><given-names>У. О.</given-names></name></name-alternatives><email>hannaimanova@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3014-4924</contrib-id><name-alternatives><name xml:lang="en"><surname>Nagajchenko</surname><given-names>Artem M.</given-names></name><name xml:lang="ru"><surname>Нагайченко</surname><given-names>А. М.</given-names></name></name-alternatives><email>hannaimanova@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Sechenov University</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет им. И.М. Сеченова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Belarusian State Medical University</institution></aff><aff><institution xml:lang="ru">Белорусский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Clinic ʺEcomedserviseʺ</institution></aff><aff><institution xml:lang="ru">Медицинский сервис «Экомедсервис»</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Privolzhsky Research Medical University</institution></aff><aff><institution xml:lang="ru">Приволжский исследовательский медицинский университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2024</year></pub-date><volume>28</volume><issue>4</issue><issue-title xml:lang="en">ONCOLOGY</issue-title><issue-title xml:lang="ru">ОНКОЛОГИЯ</issue-title><fpage>508</fpage><lpage>536</lpage><history><date date-type="received" iso-8601-date="2024-12-16"><day>16</day><month>12</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Kuznetsov A.M., Imanova K.Z., Gusarov A.M., Yackevich O.S., Zorych M.E., Korotkova N.L., Kopylova U.O., Nagajchenko A.M.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Кузнецов А.М., Иманова Х.З., Гусаров А.М., Яцкевич О.С., Зорич М.Е., Короткова Н.Л., Копылова У.О., Нагайченко А.М.</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Kuznetsov A.M., Imanova K.Z., Gusarov A.M., Yackevich O.S., Zorych M.E., Korotkova N.L., Kopylova U.O., Nagajchenko A.M.</copyright-holder><copyright-holder xml:lang="ru">Кузнецов А.М., Иманова Х.З., Гусаров А.М., Яцкевич О.С., Зорич М.Е., Короткова Н.Л., Копылова У.О., Нагайченко А.М.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/42014">https://journals.rudn.ru/medicine/article/view/42014</self-uri><abstract xml:lang="en"><p>Relevance. One of the most common birth defects is congenital cleft lip, palate and alveolar ridge. Modern aspects of surgical correction of alveolar clefts are discussed in this literature review. Approaches to performing this operation have changed significantly over time. A unified concept does not exist to this day due to the fact that the intervention can affect the growth of the upper jaw, and the fact that approaches used in pediatric surgery may not be effective in adult patients. The choice of osteoplastic materials also remains a very pressing issue, since the results of using these materials for other pathologies vary. The aim of the study is to systematize data on osteoplastic surgeries for alveolar clefts in patients of different ages and analyze of published scientific works. Materials and Methods. The authors analyzed scientific data in the search engines PubMed, Google Scholar and eLibrary. Scientific literature published from 1901 to 2024 was analyzed. Results and Discussion. At the moment, most authors are inclined to perform the operation during the period of early mixed dentition in the presence of a lateral incisor rudiment, or late mixed dentition (before the eruption of the canine) in its absence. Performing surgery in adult patients is associated with a greater degree of graft resorption and additional difficulties. Among osteoplastic materials, preference is given to autologous bone. The most popular remains an avascular autograft from the iliac crest region. Attempts are being made to avoid the use of autologous materials and to reduce its quantity in order to reduce donor morbidity. In complex cases, it may be necessary to use techniques using revascularized autografts or prosthetics. Great importance is attached to the orthodontic preparedness of patients. Conclusion. The approach to patients with alveolar cleft should be differentiated. It is important to take into account the patient’s age, somatic and dental status to select the most correct management tactics.</p></abstract><trans-abstract xml:lang="ru"><p>Актуальность. Одним из наиболее распространенных пороков развития является врожденная расщелина губы, неба и альвеолярного отростка. Костная пластика альвеолярного отростка является неотъемлемой частью реабилитации пациентов, страдающих этой патологией. В данном обзоре литературы рассмотрены современные аспекты хирургической коррекции расщелин альвеолярного отростка. Подходы к выполнению данной операции существенно изменялись с течением времени. Единой концепции на сегодняшний день не существует ввиду того, что вмешательство может влиять на рост верхней челюсти, и того, что подходы, применяемые в детской хирургии, могут быть неэффективны у взрослых пациентов. Весьма актуальным вопросом остается также выбор костно-пластических материалов, поскольку результаты применения этих материалов при других патологиях варьируют. Цель исследования - систематизация данных о костно-пластических операциях при расщелинах альвеолярного отростка у пациентов разных возрастов и анализ опубликованных научных работ. Материалы и методы. Обзор и анализ литературных источников проводился по ключевым словам на электронных ресурсах баз данных PubMed, Google Scholar, eLibrary, были использованы зарубежные и российские источники. Анализировались научная литература, напечатанная с 1901 по 2024 гг. Результаты и обсуждение. На данный момент большинство авторов склоняется к выполнению операции в период раннего сменного прикуса при наличии зачатка бокового резца, либо позднего сменного прикуса (до прорезывания клыка) при его отсутствии. Проведение операции у взрослых пациентов связывают с большей степенью резорбции трансплантата и дополнительными трудностями. Среди костно-пластических материалов предпочтение отдается аутокости. Наиболее популярным остается аваскулярный аутотрансплантат из области гребня подвздошной кости. Предпринимаются попытки ухода от применения аутоматериалов и сокращения их количества с целью уменьшения повреждения донорских зон. В сложных случаях может возникнуть необходимость применения методик с использованием реваскуляризируемых аутотрансплантатов или протезирования. Большое значение придается ортодонтической подготовленности пациентов. Выводы. Подход к пациентам с расщелиной альвеолярного отростка должен быть дифференцированным. Важно учитывать возраст пациента, соматический и стоматологический статусы для выбора наиболее корректной тактики ведения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>alveolar cleft</kwd><kwd>cleft lip and palate</kwd><kwd>bone grafting</kwd><kwd>osteoplastic materials</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>расщелина альвеолярного отростка</kwd><kwd>расщелина губы и неба</kwd><kwd>костная пластика</kwd><kwd>костно-пластические материалы</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Neudakhin EV, Prityko AG, Kugushev AYu, Meshcheryakova TI, Suleymanov AB. Pathogenic pattern of somatic disorders in children with congenital cleft lip and palate in associated connective tissue dysplasia. Russian Journal of Woman and Child Health. 2021;4(4):362—369. 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