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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">35094</article-id><article-id pub-id-type="doi">10.22363/2313-0245-2023-27-2-155-166</article-id><article-id pub-id-type="edn">ZBIHBG</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CARDIOVASCULAR DISEASES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ЗАБОЛЕВАНИЯ СЕРДЕЧНО-СОСУДИСТОЙ СИСТЕМЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Arterial hypertension in young adults</article-title><trans-title-group xml:lang="ru"><trans-title>Особенности артериальной гипертонии у лиц молодого возраста</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5937-3042</contrib-id><name-alternatives><name xml:lang="en"><surname>Bazdyreva</surname><given-names>Elena I.</given-names></name><name xml:lang="ru"><surname>Баздырева</surname><given-names>Е. И.</given-names></name></name-alternatives><email>alisheva@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9503-9236</contrib-id><contrib-id contrib-id-type="spin">9219-2116</contrib-id><name-alternatives><name xml:lang="en"><surname>Shavarova</surname><given-names>Elena K.</given-names></name><name xml:lang="ru"><surname>Шаварова</surname><given-names>Е. К.</given-names></name></name-alternatives><email>alisheva@rambler.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4382-1397</contrib-id><name-alternatives><name xml:lang="en"><surname>Ezhova</surname><given-names>Nadezhda E.</given-names></name><name xml:lang="ru"><surname>Ежова</surname><given-names>Н. Е.</given-names></name></name-alternatives><email>alisheva@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5669-9899</contrib-id><name-alternatives><name xml:lang="en"><surname>Kirpichnikova</surname><given-names>Ekaterina I.</given-names></name><name xml:lang="ru"><surname>Кирпичникова</surname><given-names>Е. И.</given-names></name></name-alternatives><email>alisheva@rambler.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5873-1768</contrib-id><contrib-id contrib-id-type="spin">9828-5409</contrib-id><name-alternatives><name xml:lang="en"><surname>Kobalava</surname><given-names>Zhanna D.</given-names></name><name xml:lang="ru"><surname>Кобалава</surname><given-names>Ж. Д.</given-names></name></name-alternatives><email>alisheva@rambler.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">City Clinical Hospital named after V.V. Vinogradov</institution></aff><aff><institution xml:lang="ru">Городская клиническая больница имени В.В. Виноградова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">RUDN University</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Pirogov Russian National Research Medical University</institution></aff><aff><institution xml:lang="ru">Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-06-29" publication-format="electronic"><day>29</day><month>06</month><year>2023</year></pub-date><volume>27</volume><issue>2</issue><issue-title xml:lang="en">CARDIOVASCULAR DISEASES</issue-title><issue-title xml:lang="ru">ЗАБОЛЕВАНИЯ СЕРДЕЧНО-СОСУДИСТОЙ СИСТЕМЫ</issue-title><fpage>155</fpage><lpage>166</lpage><history><date date-type="received" iso-8601-date="2023-06-29"><day>29</day><month>06</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Bazdyreva E.I., Shavarova E.K., Ezhova N.E., Kirpichnikova E.I., Kobalava Z.D.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Баздырева Е.И., Шаварова Е.К., Ежова Н.Е., Кирпичникова Е.И., Кобалава Ж.Д.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Bazdyreva E.I., Shavarova E.K., Ezhova N.E., Kirpichnikova E.I., Kobalava Z.D.</copyright-holder><copyright-holder xml:lang="ru">Баздырева Е.И., Шаварова Е.К., Ежова Н.Е., Кирпичникова Е.И., Кобалава Ж.Д.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/35094">https://journals.rudn.ru/medicine/article/view/35094</self-uri><abstract xml:lang="en"><p style="text-align: justify;">Arterial hypertension (AH) is associated with the development of pathological changes in target organs, which leads to an increase in morbidity and mortality. The aim of the review was to discuss the peculiarity of AH in young people, in particular risk factors for developing AH, associations between the risk of cardiovascular events and elevated blood pressure in young adults, blood pressure phenotypes in young people, the role of traditional cardiovascular diseases risk factors in young people with AH, features of target organ damages in young people with AH and optimal blood pressure for target organ protection. Threshold values of blood pressure, from which the cycle of pathological changes starts, have not been finally determined, however, it is likely that they are significantly lower than the blood pressure values that are currently used to diagnose AH n in Europe and Russia. Reclassification of AH using more strict criteria in the United States resulted in an increase in the prevalence of AH from 29 % to 43 %, and affected mainly young people. Obesity, increased daily sodium excretion, increased consumption of meat products, dyslipidemia, hyperinsulinemia, hyperuricemia, high levels of depression and low social status are among the potential risk factors for developing AH at a young age, while a low-salt diet, eating a large amount of plant foods, high in carotenoids and folate, and a high level of physical activity may have a preventive effect on the development of AH. The results of recent studies indicate a high prevalence of AH, including masked, in young people, which often remains underestimated in real clinical practice. The strategy for the treatment of AH in young patients has not been determined, which is associated with an insufficient evidence base. Studies are needed to identify additional arguments for initiating or withholding antihypertensive therapy in this population, including the study of early signs of hypertension-associated target organ damage. Conclusion. The results of recent studies indicate a high prevalence of hypertension, including masked, in young people, which often remains underestimated in real clinical practice. Further research is required to identify additional arguments for initiating or withholding antihypertensive therapy in this population, including the study of early signs of hypertension-associated target organ damage.</p></abstract><trans-abstract xml:lang="ru"><p style="text-align: justify;">Артериальная гипертензия (АГ) связана с развитием патологических изменений в органах-мишенях, что приводит к увеличению заболеваемости и смертности. Цель обзора - обсудить особенности течения АГ у лиц молодого возраста, в частности факторы риска развития АГ, ассоциации риска сердечно-сосудистых заболеваний с повышением артериального давления, фенотипы артериального давления, роль традиционных факторов риска сердечно-сосудистых заболеваний у лиц молодого возраста при АГ, особенности поражения органов-мишеней и оптимальное артериальное давление (АД) для защиты органов-мишеней. Пороговые значения АД, с которых начинается цикл патологических изменений, окончательно не определены, однако, вероятно, они значительно ниже тех значений АД, которые в настоящее время используются для диагностики АГ в Европе и России. Реклассификация АГ с использованием более строгих критериев в США привела к увеличению распространенности АГ с 29 % до 43 % и затрагивала преимущественно лиц молодого возраста. Ожирение, повышенная суточная экскреция натрия, повышенное потребление мясных продуктов, дислипидемия, гиперинсулинемия, гиперурикемия, высокий уровень депрессии и низкий социальный статус относятся к потенциальным факторам риска развития АГ в молодом возрасте, тогда как малосолевая диета, употребление в пищу большого количества растительной пищи с высоким содержанием каротиноидов и фолиевой кислоты, а также высокий уровень физической активности могут оказывать профилактическое действие на развитие АГ. Результаты исследований последних лет свидетельствуют о высокой распространенности АГ, в том числе маскированной, у лиц молодого возраста, которая в реальной клинической практике зачастую остается недооцененной. Стратегия лечения АГ у пациентов молодого возраста не определена, что связано с недостаточной доказательной базой. Необходимы исследования для выявления дополнительных аргументов в пользу начала или прекращения антигипертензивной терапии в этой популяции, включая изучение ранних признаков поражения органов-мишеней, связанных с гипертензией. Выводы. Результаты исследований последних лет свидетельствуют о высокой распространенности артериальной гипертензии, в том числе маскированной, у лиц молодого возраста, которая в реальной клинической практике зачастую остается недооцененной. Требуются дальнейшие исследования для выявления дополнительных аргументов в пользу начала или отмены антигипертензивной терапии в этой популяции, в том числе изучение ранних признаков ассоциированного с АГ поражения органов-мишеней.</p></trans-abstract><kwd-group xml:lang="en"><kwd>arterial hypertension</kwd><kwd>target organ damage</kwd><kwd>young people</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>артериальная гипертония</kwd><kwd>поражение органов-мишеней</kwd><kwd>молодые</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Luo D, Cheng Y, Zhang H, Ba M, Chen P, Li H, Chen K, Sha W, Zhang C, Chen H. Association between high blood pressure and longterm cardiovascular events in young adults: systematic review and meta-analysis. 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