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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">3454</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Molecular and genetic predictors of benign breast disease</article-title><trans-title-group xml:lang="ru"><trans-title>Молекулярно-генетические предикторы развития доброкачественных заболеваний молочных желез</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pavlova</surname><given-names>E A</given-names></name><name xml:lang="ru"><surname>Павлова</surname><given-names>Екатерина Андреевна</given-names></name></name-alternatives><bio xml:lang="en">Department of Obstetrics and Gynecology with course of Perinatology School of Medicine</bio><bio xml:lang="ru">Кафедра акушерства и гинекологии с курсом перинатологии Медицинский факультет</bio><email>katrin9-99@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ordiyants</surname><given-names>I M</given-names></name><name xml:lang="ru"><surname>Ордиянц</surname><given-names>Ирина Михайловна</given-names></name></name-alternatives><bio xml:lang="en">Department of Obstetrics and Gynecology with course of Perinatology School of Medicine</bio><bio xml:lang="ru">Кафедра акушерства и гинекологии с курсом перинатологии Медицинский факультет</bio><email>ordiyantc@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Plaksina</surname><given-names>N D</given-names></name><name xml:lang="ru"><surname>Плаксина</surname><given-names>Нина Дмитриевна</given-names></name></name-alternatives><bio xml:lang="en">Department of Obstetrics and Gynecology with course of Perinatology School of Medicine</bio><bio xml:lang="ru">Кафедра акушерства и гинекологии с курсом перинатологии Медицинский факультет</bio><email>-</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sokhova</surname><given-names>Z M</given-names></name><name xml:lang="ru"><surname>Сохова</surname><given-names>Залина Михайловна</given-names></name></name-alternatives><bio xml:lang="en">Department of Obstetrics and Gynecology with course of Perinatology School of Medicine</bio><bio xml:lang="ru">Кафедра акушерства и гинекологии с курсом перинатологии Медицинский факультет</bio><email>-</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pogasov</surname><given-names>A G</given-names></name><name xml:lang="ru"><surname>Погасов</surname><given-names>Александр Георгиевич</given-names></name></name-alternatives><bio xml:lang="en">Department of Obstetrics and Gynecology with course of Perinatology School of Medicine</bio><bio xml:lang="ru">Кафедра акушерства и гинекологии с курсом перинатологии Медицинский факультет</bio><email>-</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Peoples’ Friendship University of Russia</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-05-15" publication-format="electronic"><day>15</day><month>05</month><year>2013</year></pub-date><issue>S5</issue><issue-title xml:lang="en">NOS5 (2013)</issue-title><issue-title xml:lang="ru">№S5 (2013)</issue-title><fpage>225</fpage><lpage>229</lpage><history><date date-type="received" iso-8601-date="2016-09-07"><day>07</day><month>09</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="ru">Copyright ©; 2013, Павлова Е.А., Ордиянц И.М., Плаксина Н.Д., Сохова З.М., Погасов А.Г.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Павлова Е.А., Ордиянц И.М., Плаксина Н.Д., Сохова З.М., Погасов А.Г.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/3454">https://journals.rudn.ru/medicine/article/view/3454</self-uri><abstract xml:lang="en">This article presents the current data of world literature, highlighting the role of estrogen metabolites and regulation of this process in the pathogenesis of breast diseases.</abstract><trans-abstract xml:lang="ru">В данной статье представлены современные данные мировой литературы, освещающие роль метаболизма эстрогенов и регуляции этого процесса в патогенезе заболеваний молочной железы (МЖ).</trans-abstract><kwd-group xml:lang="en"><kwd>benign breast diseases</kwd><kwd>estradiol</kwd><kwd>estrone</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>гиперплазия молочных желез</kwd><kwd>эстрадиол</kwd><kwd>эстрон</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Alan A., Arslan Roy E. 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