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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">3451</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Chronic pelvic inflammatory disease: controversial issues</article-title><trans-title-group xml:lang="ru"><trans-title>Хронические воспалительные заболевания органов малого таза: контраверсии сегодняшнего дня</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dukhin</surname><given-names>A O</given-names></name><name xml:lang="ru"><surname>Духин</surname><given-names>Армен Олегович</given-names></name></name-alternatives><bio xml:lang="en">Department of Obstetrics &amp; Gynecology with course of Perinatology</bio><bio xml:lang="ru">Кафедра акушерства и гинекологии с курсом перинатологии Медицинский факультет</bio><email>igoroparin@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Luybeshkina</surname><given-names>V A</given-names></name><name xml:lang="ru"><surname>Любешкина</surname><given-names>Вера Александровна</given-names></name></name-alternatives><bio xml:lang="en">Department of Obstetrics &amp; Gynecology with course of Perinatology</bio><bio xml:lang="ru">Кафедра акушерства и гинекологии с курсом перинатологии Медицинский факультет</bio><email>vap.med.ru@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Taraskina</surname><given-names>E V</given-names></name><name xml:lang="ru"><surname>Тараскина</surname><given-names>Елена Викторовна</given-names></name></name-alternatives><bio xml:lang="en">Department of Obstetrics &amp; Gynecology with course of Perinatology</bio><bio xml:lang="ru">Кафедра акушерства и гинекологии с курсом перинатологии Медицинский факультет</bio><email>elena.taraskina@pochta.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Peoples’ Friendship University of Russia</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-05-15" publication-format="electronic"><day>15</day><month>05</month><year>2013</year></pub-date><issue>S5</issue><issue-title xml:lang="en">NOS5 (2013)</issue-title><issue-title xml:lang="ru">№S5 (2013)</issue-title><fpage>201</fpage><lpage>209</lpage><history><date date-type="received" iso-8601-date="2016-09-07"><day>07</day><month>09</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="ru">Copyright ©; 2013, Духин А.О., Любешкина В.А., Тараскина Е.В.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Духин А.О., Любешкина В.А., Тараскина Е.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/3451">https://journals.rudn.ru/medicine/article/view/3451</self-uri><abstract xml:lang="en">Pelvic inflammatory disease (PID) is one of the most common serious infection of nonpregnant women of reproductive age. Goals of the therapy must include the resolution of clinical signs, the eradication of pathogens from genital tract and the prevention of sequelae primarily including the development of chronic inflammation. The paper deals with the currennt problems and contraversial issues of chronic pelvic inflammatory disease. This review presents the results of domestic and foreign studies, and the own view of the issue, the prospects and possible solutions.</abstract><trans-abstract xml:lang="ru">Воспалительные заболевания органов малого таза (ВЗОМТ) — наиболее распространенные и достаточно серьезные инфекционные заболевания, встречающиеся у женщин репродуктивного возраста. Цель лечения должна заключаться не только в исчезновении симптомов, эррадикации инфекта из половых путей, но и в предупреждении развития возможных осложнений, в первую очередь развития хронического воспаления. Статья посвящена существующим в настоящее время проблемам и спорным вопросам в отношении хронических воспалительных заболеваний органов малого таза. В обзоре представлены данные отечественных и зарубежных исследований, а также собственный взгляд на проблему, перспективы и возможные пути ее решения.</trans-abstract><kwd-group xml:lang="en"><kwd>pelvic inflammatory disease</kwd><kwd>chronic inflammation</kwd><kwd>reproductive health</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>воспалительные заболевания органов малого таза</kwd><kwd>хроническое воспаление</kwd><kwd>репродуктивное здоровье</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Bakoulev A.L. Inflammatory disease of an infectious nature genitals in women: a textbook for higher schools. — M.: Dropha, 2008. — 152 p.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>CDC STD Treatment Guidelines 2010. MMWR. 2010; 59 (RR-12): 110 p.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Gazazyan M.G., Khardikov A.V. Effective approach to the diagnosis of chronic pelvic pain syndrome // Status Praesens 1 [7 ], 2012 — P. 59—65.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Gasparov E.S., Dubinskaya E.D. Pelvic peritoneal adhesions: etiology, pathogenesis, diagnosis, prevention. — Moscow: LLC «Publisher “Medical Information Agency”, 2013. — P. 168.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Glyakin D.S., Samoilova A.V., Gunin A.G. Pro-inflammatory cytokines in patients with endometrial cancer // Problems reproduction. — 2012. — 1. — P. 35—38.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Hunanyan A.R., Sidorova I.S., Kogan E.A. The role of the combination of HPV infection and chronic endometritis in the pathogenesis of endometrial cancer // Status presens. — 2012. — № 3 (9). — P. 23—26.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Heystek M., Ross J. A randomized doublr-blind comparison of moxifloxacin and doxycycline/metronidazole/ciprofloxacin in the treatment of acute, uncomplicated pelvic inflammatory disease // Int. J. STD AIDS. — 2009. — Vol. 20. — P. 690—5.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Ignatov A. APC promoter hypermethylation is an early event in endometrial tumorogenesis // Cancer Sci. — 2010. — 101 (2). — P. 321.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Jaiyeoba O., Lazenby G., Soper D.E. Recommendations and rationale for treatement of pelvic inflammatory disease // Expert. Rev. Anti Infect. Ther. — 2011. — Vol. 9 (1). — P. 61—70.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Judlin P., Liao Q., Liu Z. Efficacy and safety of moxifloxacin in uncomplicated pelvic inflammatory disease: the MONALISA study // BJOG. — 2010. — Vol. 117 (12). — P. 1475—84.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Khryanin A.A., Stetsyuk O.U., Andreeva I.V. Chlamydial infection in gynecology and obstetrics: the tactics of the patients in accordance with the modern Russian and foreign recommendations // Attending physician. — 2012. — № 3. — P. 2—11.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Kulakov V.I., Manukhin I.B., Savelieva G.M. Gynecology national guidance. — Moscow: GEOTAR-Media, 2011.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Maternity advice bureau / Ed. V.E. Radzinskogo. — Moscow: GEOTAR-Media, 2010. — P. 472.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Melkumian A.R., Berezhansky B.V. The species spectrum and antibiotic sensitivity of opportunistic pathogens isolated from patients with endometritis // Clinical Microbiology and Antimicrobial Chemotherapy. — 2013. — Vol. 15. — № 2. — P. 31.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Neumark A.I., Acker L.V. Chronic pelvic pain syndrome in urogynecology. — Moscow: LLC «Publisher “Medical Information Agency”, 2009. — Р. 240.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Nieminen T.T. Molecular analysis of endometrial tumorogenesis: importance of complex hyperplasia regardless of atypia // Clin Cancer Res. — 2009. — 15 (18). — P. 5772—83.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Park J.H., Lee B.I., Song E.S. Hypermethylation of E-cagherin in endometrial carcinoma // J Gynec Oncol. — 2008. — 19(4). — P. 241—5.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Obstetrics and gynecology: a guide for practitioners. — Moscow: Remedium, 2009. — P. 352.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Plahova K.I., Rakhmatullina M.R. Immune and genetic factors of reproductive disorders associated with urogenital chlamydial infection in humans. // Journal of Dermatology and Venereology. — 2010. — № 6. — P. 39—45.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Prilepskaya V.N., Dovlethanova E.R. Reproductive health and chlamydial infection // Gynecology. — 2013. — Vol. 15. — № 1. — P. 4—7.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Prilepskaya V.N., Yaglov V.V. Inflammatory disease of the pelvic organs. — Moscow: GEOTAR-Media, 2010. — 128 p.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Radzinsky V.E. Reproductive Health: A Training Manual. — Moscow: Peoples’ Friendship University of Russia, 2011. — 728 p.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Radzinsky V.E. Gynecology: a guide to practical training. — Moscow: GEOTAR Media, 2013.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Radzinsky V.E., Dimitrova V.I., Mayskova I.Yu. Not developing pregnancy. — Moscow: GEOTAR-Media, 2009.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Radzinsky V.E., Dukhin A.O. Comment on the article // Obstetrics and Gynecology: news, views, and training. — 2013. — № 1. — P. 29—31.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Ross J. IUSTI. European Guideline for the Management of Pelvic Inflammatory Disease, 2012.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Russian Statistical Yearbook 2011 Stat. sb. / Rosstat. — M., 2011. — P. 795.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Samoilov M.B., Serebrennikova K.G. Algorithm for clinical and morphological examination of endometrium in preparation for the treatment of infertility methods of assisted reproductive technology // Russian Medical Journal. — 2009. — № 2. — P. 29—32.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Semyatov S.M. Reproductive health of adolescent girls Moscow metropolis in the contemporary socio-economic and environmental conditions: // dissertation of the PhD. / RAMS. — Moscow, 2009.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Serov V.N., Tverdikova M.A. Inflammatory diseases of the pelvic organs: diagnostic criteria and treatment guidelines // Breast cancer. — 2011. — Vol. 19. — № 1. — P. 46—50.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Soleymani H. GPs should be vigilant for pelvic inflammatory disease // Practioner — 2011. — Mar. — P. 15—8.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Stanojevic I.V., Zaletaev I.V. Abnormal methylation of several genes in endometrial hyperplasia with chronic endometritis // Russian Journal of obstetrician-gynecologist. — 2012. — Vol. 12. — № 1. — P. 20—3.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Stenyaeva N.N., Apolikhina I.A. Chronic pelvic pain: psychosomatic aspects // Consilium medicum. — 2012. — Vol. 14. — № 6. — P. 19—22.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Sukhikh G.T., Shurshalina A.V. Chronic endometritis. — Moscow: GEOTAR-Media, 2013.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>System of genetic and epigenetic markers in diagnosing cancer / Ed. M.A. Paltseva, I.V. Zaletaeva. — Moscow: Medicine, 2009.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Tabakman Yu.Yu. Endometrial cancer: a guide for physicians. — M.: The practice of medicine, 2009.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Warren J.W., Morozov V. Could chronic pelvic pain be a functional somatic syndrome? // Am J Obstet Gyn. — 2011. — Apr. — P. 14—7.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Wolny P.M., Banerji S. Analysis of CD44-hyaluronan interactions in an artificial membrane system: insights into the distinct binding properties of high and low molecular weight hyaluronan // J Biol Chem. — 2010. — 285 (39). — P. 30170—80.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Zhou J., Nagarkatti P.S. Unique SNP in CD44 intron 1 and its role in breast cancer development // Anticancer Res. — 2010. — 30(4). — P. 1263—72.</mixed-citation></ref></ref-list></back></article>
