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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">34089</article-id><article-id pub-id-type="doi">10.22363/2313-0245-2023-27-1-57-64</article-id><article-id pub-id-type="edn">TBEROF</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>GINECOLOGY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Uterine fibroids: modern methods of treatment, advantages and complications</article-title><trans-title-group xml:lang="ru"><trans-title>Миома матки: современные методики, преимущества и осложнения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1434-0386</contrib-id><name-alternatives><name xml:lang="en"><surname>Aleynikova</surname><given-names>Ekaterina Yu.</given-names></name><name xml:lang="ru"><surname>Алейникова</surname><given-names>Е. Ю.</given-names></name></name-alternatives><email>ketall@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6711-1563</contrib-id><name-alternatives><name xml:lang="en"><surname>Solovyeva</surname><given-names>Alina V.</given-names></name><name xml:lang="ru"><surname>Соловьева</surname><given-names>А. В.</given-names></name></name-alternatives><email>ketall@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Peoples’ Friendship University of Russia</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-03-27" publication-format="electronic"><day>27</day><month>03</month><year>2023</year></pub-date><volume>27</volume><issue>1</issue><issue-title xml:lang="en">GINECOLOGY</issue-title><issue-title xml:lang="ru">ГИНЕКОЛОГИЯ</issue-title><fpage>57</fpage><lpage>64</lpage><history><date date-type="received" iso-8601-date="2023-03-27"><day>27</day><month>03</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Aleynikova E.Y., Solovyeva A.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Алейникова Е.Ю., Соловьева А.В.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Aleynikova E.Y., Solovyeva A.V.</copyright-holder><copyright-holder xml:lang="ru">Алейникова Е.Ю., Соловьева А.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/34089">https://journals.rudn.ru/medicine/article/view/34089</self-uri><abstract xml:lang="en"><p style="text-align: justify;">The state of the reproductive system by women with uterine fibroids is considered as a part of this literature review. The main clinical manifestations of myomatous nodes were identified by writing the review: abnormal uterine and heavy menstrual bleeding, infertility, miscarriage, chronic pelvic pain, dysfunction of adjacent organs, which are indications for surgical treatment. It is noted that approximately 30 % of women with uterine fibroids suffer from abnormal uterine bleeding, leading to anemia and reduced quality of life. Chronic pelvic pain significantly reduces the quality of life of patients, worsening their functional and mental state and disrupting sexual function. This review focuses on reproductive problems in women with leiomyoma. Taking into consideration the high prevalence of this nosology and the need to preserve the fertility of patients, the review describes modern methods of treating patients with uterine myoma, including drug therapy surgical treatment and alternative methods. Currently, in order to stop the symptoms of uterine fibroids, as well as for preoperative preparation, conservative therapy is used, which allows to reduce pain, restore hemoglobin levels, reduce intraoperative blood loss and reduce surgery time. Reproductive disorders associated with uterine fibroids, such as infertility, recurrent miscarriage, and adverse obstetric outcomes, are a significant reason to improve organ-preserving therapies or develop new ones. Although hysterectomy is a radical treatment for uterine fibroids, it is unacceptable for patients who have not realized their reproductive function. Therefore, the most justified intervention is myomectomy with various surgical approaches, and as an alternative treatment, uterine artery embolization, radiofrequency ablation or high-intensity focused ultrasound treatment of uterine fibroids. These data allow us to conclude that the high prevalence and versatility of symptoms of uterine fibroids among patients of reproductive age determine the relevance of searching for optimal methods of treatment.</p></abstract><trans-abstract xml:lang="ru"><p style="text-align: justify;">В рамках литературного обзора рассматривается состояние репродуктивной системы у женщин с миомой матки. При написании обзора авторы выявлили основные клинические проявления миоматозных узлов: аномальные маточные и обильные менструальные кровотечения, бесплодие, невынашивание беременности, хроническая тазовая боль, нарушение функций смежных органов, которые являются показаниями для оперативного лечения. Отмечается, что примерно 30 % женщин с миомой матки страдают аномальными маточными кровотечениями, приводящими к их анемизации и снижению качества жизни. Хроническая тазовая боль заметно снижает качество жизни пациенток, ухудшая их функциональное и психическое состояние и нарушая сексуальную функцию. В данном обзоре особое внимание уделяется проблемам репродукции у женщин с лейомиомой. С учетом высокой распространенности данной нозологии и необходимости сохранения фертильности пациенток описаны современные методы лечения пациенток с миомой матки, включая медикаментозную терапию, хирургическое лечение и альтернативные методы. В настоящее время с целью купирования симптомов миомы матки, а также для предоперационной подготовки используется консервативная терапия, которая позволяет снизить болевой синдром, восстановить уровень гемоглобина, уменьшить кровопотерю во время операции и длительность операции. Нарушения репродуктивной функции, ассоциированные с миомой матки, такие как бесплодие, привычное невынашивание беременности и неблагоприятные акушерские исходы, являются весомым поводом для усовершенствования органосохраняющих методов лечения или разработки новых. Несмотря на то, что гистерэктомия является радикальным методом лечения миомы матки, она неприемлема для пациенток, которые еще не реализовали свою репродуктивную функцию. Поэтому наиболее оправданным вмешательством является миомэктомия различными хирургическими доступами, а в качестве альтернативного лечения - эмболизация маточных артерий, радиочастотная абляция или высокоинтенсивное сфокусированное ультразвуковое лечение миомы матки. Приведенные данные позволяют сделать вывод, что высокая распространенность и многогранность симптомов миомы матки среди пациенток репродуктивного возраста определяют актуальность поиска оптимальных методов лечения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>uterine fibroids</kwd><kwd>abnormal uterine bleeding</kwd><kwd>infertility</kwd><kwd>miscarriage</kwd><kwd>myomectomy</kwd><kwd>hysterectomy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>миома матки</kwd><kwd>аномальные маточные кровотечения</kwd><kwd>бесплодие</kwd><kwd>невынашивание беременности</kwd><kwd>миомэктомия</kwd><kwd>гистерэктомия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Stewart E, Cookson C, Gandolfo R, Schulze-R ath R. Epidemiology of uterine fibroids: a systematic review. 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