<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">3395</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Clinical particularities of pregnancy in the periodic disease and special considerations in the prenatal care</article-title><trans-title-group xml:lang="ru"><trans-title>Особенности течения беременности и ведения беременных при периодической болезни</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Abramyan</surname><given-names>R A</given-names></name><name xml:lang="ru"><surname>Абрамян</surname><given-names>Р А</given-names></name></name-alternatives><email>ipog@radionet.am</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Avagyan</surname><given-names>G S</given-names></name><name xml:lang="ru"><surname>Авагян</surname><given-names>Г С</given-names></name></name-alternatives><email>ipog@radionet.am</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Abramyan</surname><given-names>L R</given-names></name><name xml:lang="ru"><surname>Абрамян</surname><given-names>Л Р</given-names></name></name-alternatives><email>ipog@radionet.am</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Institute of Perinatology, Obstetrics and Gynecology Republic of Armenia Healthcare Ministry</institution></aff><aff><institution xml:lang="ru">Институт Перинатологии, акушерства и гинекологии, МЗ РА</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-05-15" publication-format="electronic"><day>15</day><month>05</month><year>2011</year></pub-date><issue>S5</issue><issue-title xml:lang="en">NOS5 (2011)</issue-title><issue-title xml:lang="ru">№S5 (2011)</issue-title><fpage>164</fpage><lpage>170</lpage><history><date date-type="received" iso-8601-date="2016-09-07"><day>07</day><month>09</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="ru">Copyright ©; 2011, Абрамян Р.А., Авагян Г.С., Абрамян Л.Р.</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Абрамян Р.А., Авагян Г.С., Абрамян Л.Р.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/3395">https://journals.rudn.ru/medicine/article/view/3395</self-uri><abstract xml:lang="en">The problem of studying the periodic disease (PD) has almost a centennial history. A new stage in diagnosing and evaluating the prevalence of the PD in various populations was due to an essential discovery of the MEFV (MEditerranean FeVer) gene localized in the chromosome 16p13.3. Colchicine remains the only officially accepted medicine for PD treatment and renal amyloidosis prevention. However, from the perspective of the perinatal pharmacotherapy with a glance to colchicine’s teratogenic effect its use in obstetrics is inappropriate.</abstract><trans-abstract xml:lang="ru">Проблема изучения периодической болезни (ПБ) имеет почти вековую историю. Новый этап в диагностике и исследовании распространенности ПБ в различных популяциях ознаменовался принципиально важным открытием гена MEFV (MEditerranean FeVer), локализованного в хромосоме 16p 13.3. Колхицин продолжает оставаться единственным официально принятым препаратом для лечения ПБ и профилактики АП. Однако с позиции перинатальной фармакотерапии и тератогенного эффекта нецелесообразно его применение в акушерстве.</trans-abstract><kwd-group xml:lang="en"><kwd>KanJang®</kwd><kwd>ImmunoGuard®</kwd><kwd>periodic disease</kwd><kwd>colchicines</kwd><kwd>KanJang®</kwd><kwd>ImmunoGuard®</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>периодическая болезнь</kwd><kwd>колхицин</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Акушерство: Национальное руководство / Под ред. Э.К. Айламазяна и др. – М., 2007.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Амарян Г.Г., Шахсуварян Г.Р., Саркисян Т.Ф. Оценка эффективности действия фитоадаптогена ImmunoGuard при семейной средиземноморской лихорадке у взрослых // Мат-лы науч. конф. EГМУ. – Ереван, 2007. – С. 209–210.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Аствацатрян В.А., Моханова Л.А. К вопросу о так называемой периодической болезни // Педиатрия. – 1962. – № 8. – С. 85–87.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Виноградова О.М. Периодическая болезнь. – М., 1973.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Радзинский В.Е. Руководство к практическим занятиям по акушерству. – М., 2007.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Радзинский В.Е., Ордиянц И.М., Оразмурадов А.А. Женская консультация. – 2-е изд. – Петрозаводск, 2007.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Amaryan G., Hambartsumyan M. Correlation between nitric oxide, IL-6 and IL-10 level in blood plasma of children with familial Mediterranean fever after treatment with Immu-noGuard // J. Immunopathology. 3rd World Congress on Clinical Pathology. Pattaja. – 2005. – Р.110-111.</mixed-citation></ref></ref-list></back></article>
