RUDN Journal of MedicineRUDN Journal of Medicine2313-02452313-0261Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)3364Research ArticleJustification of composition of isosorbite dinitrate gel for treatment of chronic anal fissuraLasarCDepartment of General pharmaceutical and biomedical technologysjl512am@hotmail.comSuslinaS NDepartment of General pharmaceutical and biomedical technologysvetlana-suslina@yandex.ruPeoples’ Friendship University of Russia150420134747807092016Copyright © 2013,2013The article is devoted to the study of solubility izorbite dinitrate to establish the possibility of obtaining a gel form of the substance for the development of applicative dosage forms for local treatment of chronic anal fissure.isosorbid dinitaratechronic anal crackgelизорбида динитратхроническая анальная трещинагель