RUDN Journal of MedicineRUDN Journal of MedicineВестник Российского университета дружбы народов. Серия: Медицина2313-02452313-0261Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)3354ArticlesСтатьиResearch ArticleMetalloproteinases concentration in the blood serum before and after surgical removal of the tumorКонцентрации металлопротеиназ в сыворотке крови до и после хирургического удаления опухолиKuznetsovaO MКузнецоваОльга МатвеевнаDepartment of BiochemistryКафедра биохимии Медицинский факультетolya.k@mail.ruBerezovT TБерезовТемирболат ТемболатовичDepartment of BiochemistryКафедра биохимии Медицинский факультет-ChibisovaA YuЧибисоваА ЮDepartment of BiochemistryКафедра биохимии Медицинский факультет-Peoples Friendship University of RussiaРоссийский университет дружбы народов150420134NO4 (2013)№4 (2013)5907092016Copyright ©; 2013, Кузнецова О.М., Березов Т.Т., Чибисова А.Ю.2013Кузнецова О.М., Березов Т.Т., Чибисова А.Ю.http://creativecommons.org/licenses/by/4.0https://journals.rudn.ru/medicine/article/view/3354The concentrations of matrix metalloproteinases-2, -7 and -9 in the blood serum of patients with breast cancer were measured both before and two weeks after the surgical removal of the tumor. The comparative analysis of the data was carried out.Проведено иммуноферментное определение и сравнительный анализ содержания матриксных металлопротеиназ-2, -7 и -9 в сыворотке крови пациенток больных раком молочной железы (РМЖ) до и спустя две недели после хирургического удаления опухоли.metalloproteinaseimmunoenzyme assaybreast cancer1.Brun J.L., Cortez A., Lesieur B. et al. Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer // Oncology Reports. — 2012. — 27(4). — P. 1049—57.2.Yeo N.K., Eom D.W., Oh M.Y. et al. Expression of matrix metalloproteinase 2 and 9 and tissue inhibitor of metalloproteinase 1 in nonrecurrent vs recurrent nasal polyps // Ann Allergy Asthma Immunol. — 2013. — 111(3). — P. 205—210.3.Li S., Wu Y., Keating S.M., Du H., Sammet C.L., Zadikoff C., Mahadevia R,. Epstein L.G., Ragin A.B. Matrix metalloproteinase levels in early HIV infection and relation to in vivo brain status // J Neurovirology. — 2013. Epub ahead of print.4.Zhao M., Hu H.G,. Huang J., Zou Q., Wang J., Liu M.Q., Zhao Y., Li G.Z., Xue S., Wu Z.S. Expression and correlation of Twist and gelatinases in breast cancer // Exp Ther Med. — 2013. — 6(1). — P. 97—100.5.Deryugina E.I., Quigley J.P. Pleiotropic Roles of Matrix Metalloproteinases in Tumor Angiogenesis: Contrasting, Overlapping and Compensatory Functions // Biochim Biophys Acta. — 2010. — 1803(1). — P. 103—120.6.Delassus G.S., Cho H., Hoang S. et al. Many new down — and up-regulatory signaling pathways, from known cancer progression suppressors to matrix metalloproteinases, differ widely in cells of various cancers // Cell Physiol. — 2010. — 224(2). — Р. 549—558.