RUDN Journal of MedicineRUDN Journal of MedicineВестник Российского университета дружбы народов. Серия: Медицина2313-02452313-0261Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)3347ArticlesСтатьиReview ArticleMolecular-based diagnosis methods of the endometrium hyperplasiaМолекулярные методы диагностики гиперплазии эндометрияSlyusarevaO AСлюсареваОльга АлександровнаLelechka.86@mail.ruPeoples’ Friendship University of RussiaРоссийский университет дружбы народов150220162NO2 (2016)№2 (2016)17618007092016Copyright ©; 2016, Слюсарева О.А.2016Слюсарева О.А.http://creativecommons.org/licenses/by/4.0https://journals.rudn.ru/medicine/article/view/3347Modern endometrium hyperplasia molecular-based diagnosis methods described in the article.В статье описываются современные молекулярные методы диагностики гиперплазии эндометрия.PTENPAXCOX-2K-rasbcl2baxKi-67PCNAendometrial hyperplasiaPTENPAXCOX-2K-rasβ-cateninbcl2baxKi-67PCNAгиперплазия эндометрияβ-катенин1.Abike F., Tapisiz O.L., Zergeroglu S., et al. PCNA and KI-67 in endometrial hyperplasias and evaluation of the potential of malignancy. Eur. J. Gynaecol. Oncol. 2011. Vol. 32. No. 1. P. 77-80.2.Allison K.H., Upson K., Reed S.D. et al. PAX2 loss by immunohistochemistry occurs early and often in endometrial hyperplasia. Int. J. Gynecol. Pathol. 2012. Vol. 31. No. 2. P. 151-159.3.Amalinei C., Cianga C., Balan R. et al. Immunohistochemical analysis of steroid receptors, proliferation markers, apoptosis related molecules, and gelatinases in non-neoplastic and neoplastic endometrium. Ann. Anat. 2011. Vol. 193. No. 1. P. 43-55.4.Antonsen S.L., Ulrich L., Høgdall C. Patients with atypical hyperplasia of the endometrium should be treated in oncological centers. Gynecol. Oncol. 2012. Vol. 125. No. 1. P. 124-128.5.Armstrong A.J., Hurd W.W., Elguero S. et al. Diagnosis and management of endometrial hyperplasia. J. Minim. Invasive. Gynecol. 2012. Vol. 19. No. 5. P. 562-571.6.Chernuha G.E., Dumanovskaya M.R. Current views on endometrial hyperplasia. Obstetrics and Gynecology. 2013. No. 3. P. 26-32.7.Chernuha G.E., Dumanovskaya M.R., Burmenskaya O.V. et al. Expression of genes which regulate apoptosis in different types of endometrial hyperplasia and endometrial carcinoma. Obstetrics and Gynecology. 2013. No. 1. P. 63-69.8.Daud S., Jalil S.S., Griffin M. Endometrial hyperplasia - the dilemma of management remains: a retrospective observational study of 280 women. Eur. J. Obstet. Gynecol. Reprod. Biol. 2011. Vol. 159. No. 1. P. 172-175.9.Gallos I.D., Ofinran O., Shehmar M. et al. Current management of endometrial hyperplasia-a survey of United Kingdom consultant gynaecologists. Eur. J. Obstet. Gynecol. Reprod. Biol. 2011. Vol. 118. No. 2. P. 305-307.10.Gunderson C.C., Fader A.N., Carson K. et al. Oncologic and reproductive outcomes with progestin therapy in women with endometrial hyperplasia and grade 1 adenocarcinoma: a systematic review. Gynecol. Oncol. 2012. Vol. 125. No. 2. P. 477-482.11.Gynecology. Guidance for practical training: a training manual. Ed. V.E. Radzinsky. 3rd ed. GEOTAR Media, 2013. P. 552.12.Radzinsky V.E., Fuks A.M. Gynecology. GEOTAR-media, 2014. P. 1000.13.Lacey J.V.Jr., Chia V.M., Rush B.B. Incidence rates of endometrial hyperplasia, endometrial cancer and hysterectomy from 1980 to 2003 within a large prepaid health plan. Int. J. Cancer. 2012. Vol. 131. No. 8. P. 1921-1929.14.Morotti M., Menada M.V., Moioli M. et al. Frozen section pathology at time of hysterectomy accurately predicts endometrial cancer in patients with preoperative diagnosis of atypical endometrial hyperplasia. Gynecol. Oncol. 2012. Vol. 125. No. 3. P. 536-540.15.Pieczyńska B., Wojtylak S., Zawrocki A. et al. Analysis of PTEN, estrogen receptor α and progesterone receptor expression in endometrial hyperplasia using tissue microarray. Pol. J. Pathol. 2011. Vol. 62. No. 3. P. 133-138.16.Reproductive health: Manual guide. Ed. V.E. Radzinsky. Peoples’ Friendship University, 2011.17.Steinbakk A., Gudlaugsson E., Aasprong O.G. et al. Molecular biomarkers in endometrial hyperplasias predict cancer progression. Am. J. Obstet. Gynecol. 2011. Vol. 204. No. 4. P. 357e1-357e12.