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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">3345</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Epigenetics and epigenetic mechanisms in myoma</article-title><trans-title-group xml:lang="ru"><trans-title>Эпигенетика и эпигенетические абберации при миоме матки</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Eseneeva</surname><given-names>F M</given-names></name><name xml:lang="ru"><surname>Есенеева</surname><given-names>Фарида Мухарбиевна</given-names></name></name-alternatives><email>eseneeva85@bk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kiselev</surname><given-names>V I</given-names></name><name xml:lang="ru"><surname>Киселев</surname><given-names>Всеволод Иванович</given-names></name></name-alternatives><email>vkis10@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Salimova</surname><given-names>L Y</given-names></name><name xml:lang="ru"><surname>Салимова</surname><given-names>Лейла Яшаровна</given-names></name></name-alternatives><email>leilasal@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Peoples’ Friendship University of Russia</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Research division of early carcinogenesis, prevention, diagnosis and complex treatment of oncological diseases of the female reproductive organs fsbi “Russian scientific center of radiology”</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российский научный центр рентгенорадиологии»</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">V.M. Buyanov City Clinical Hospital</institution></aff><aff><institution xml:lang="ru">Городская клиническая больница им. В.М. Буянова</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2016</year></pub-date><issue>2</issue><issue-title xml:lang="en">NO2 (2016)</issue-title><issue-title xml:lang="ru">№2 (2016)</issue-title><fpage>160</fpage><lpage>170</lpage><history><date date-type="received" iso-8601-date="2016-09-07"><day>07</day><month>09</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="ru">Copyright ©; 2016, Есенеева Ф.М., Киселев В.И., Салимова Л.Я.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Есенеева Ф.М., Киселев В.И., Салимова Л.Я.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/3345">https://journals.rudn.ru/medicine/article/view/3345</self-uri><abstract xml:lang="en">This article is about main modern aspects of pathogenesis of myoma, including epigenetics. The authors made an attempt to demonstrate the most investigated epigenetic mechanisms, perspectives of their researching and possible application in practice.</abstract><trans-abstract xml:lang="ru">В статье приведен краткий обзор основных современных направлений патогенеза миомы матки, отдельно выделена эпигенетика как самостоятельная наука, изложены наиболее изученные эпигенетические механизмы, произведена попытка оценить роль эпигенетики в патогенезе миомы матки, а также рассмотрены возможные перспективы изучения эпигенетических механизмов и применения в практике.</trans-abstract><kwd-group xml:lang="en"><kwd>myoma</kwd><kwd>epigenetics</kwd><kwd>epigenetic mechanisms</kwd><kwd>DNA methylation</kwd><kwd>Histone modification</kwd><kwd>Micro RNA</kwd><kwd>Epigenetic therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>миома матки</kwd><kwd>эпигенетика</kwd><kwd>эпигенетические механизмы</kwd><kwd>ДНК-метилирование</kwd><kwd>модификация гистонов</kwd><kwd>«замалчивание» микро-РНК</kwd><kwd>эпигенетическая терапия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Asada H., Yamagata Y., Taketani T. et al. 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