<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">3341</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Vulvar dystrophic diseases in menopausal women</article-title><trans-title-group xml:lang="ru"><trans-title>Дистрофические болезни промежности в менопаузальном периоде</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Blbulyan</surname><given-names>T A</given-names></name><name xml:lang="ru"><surname>Блбулян</surname><given-names>Татевик Арменовна</given-names></name></name-alternatives><email>tblbulyan@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Klimova</surname><given-names>O I</given-names></name><name xml:lang="ru"><surname>Климова</surname><given-names>Ольга Ивановна</given-names></name></name-alternatives><email>koiv01@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pogasov</surname><given-names>A G</given-names></name><name xml:lang="ru"><surname>Погасов</surname><given-names>Александр Георгиевич</given-names></name></name-alternatives><email>blbulyan@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sokhova</surname><given-names>Z M</given-names></name><name xml:lang="ru"><surname>Сохова</surname><given-names>Залина Михайловна</given-names></name></name-alternatives><email>blbulyan@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Peoples’ Friendship University of Russia</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2016</year></pub-date><issue>2</issue><issue-title xml:lang="en">NO2 (2016)</issue-title><issue-title xml:lang="ru">№2 (2016)</issue-title><fpage>133</fpage><lpage>137</lpage><history><date date-type="received" iso-8601-date="2016-09-07"><day>07</day><month>09</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="ru">Copyright ©; 2016, Блбулян Т.А., Климова О.И., Погасов А.Г., Сохова З.М.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Блбулян Т.А., Климова О.И., Погасов А.Г., Сохова З.М.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/3341">https://journals.rudn.ru/medicine/article/view/3341</self-uri><abstract xml:lang="en">Dystrophic processes of a vulva were and remain a problem of both practical and theoretical medicine. Despite considerable achievements on the basis of highlighted fundamental medicine questions of an etiopatogenesis, it continues to remain not fully elucidated. It is supposed that more thorough investigation skin aging processes can conceptually change our pathological understanding, in this case dystrophic changes of skin of a vulva and vagina. Correction methods remain unresolved, although there is obvious progress in this field.</abstract><trans-abstract xml:lang="ru">Дистрофические процессы вульвы были и остаются проблемой как практической, так и теоретической медицины. Несмотря на значительные достижения на основе открытий фундаментальной медицины, вопросы этиопатогенеза продолжают оставаться не до конца ясными. Предполагается, что более углубленное изучение процессов старения кожи концептуально может изменить наше понимание патологических, в данном случае дистрофических изменений кожи вульвы и влагалища. Открытыми остаются методы коррекции, хотя определенный прогресс в этом налицо.</trans-abstract><kwd-group xml:lang="en"><kwd>dystrophy</kwd><kwd>vulva</kwd><kwd>skin ageing</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>дистрофия</kwd><kwd>вульва</kwd><kwd>старение кожи</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Bornstein J., Sideri M., Tatti S. et al. Terminology of the Vulva of the International Federation for Cervical Pathology and Colposcopy. Journal of Lower Genital Tract Disease. 2012. V. 16. Iss. 3. P. 290-295.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Calleja-Agius J., Brincat M., Borg M. Skin connective tissue and ageing. Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology. 2013. V. 27. P. 727-740.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Da Silva D., Woodham A., Naylor P. et al. Immunostimulatory Activity of the Cytokine-Based Biologic, IRX-2, on Human Papillomavirus-Exposed Langerhans Cells. J. Interferon Cytokine Res. 2015.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Doyen J., Demoulin S., Delbecque K. et al. Vulvar Skin Disorders throughout Lifetime: About Some Representative Dermatoses. BioMed Research International. 2014. V. 2014.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Ferreira da Silva W., Pagliari C., Duarte M. et al. Paracoccidioides brasiliensis interacts with dermal dendritic cells and keratinocytes in human skin and oral mucosa lesions. Med. Mycol. 2016.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Fistarol K., Itin P. Diagnosis and Treatment of Lichen Sclerosus. American Journal of Clinical Dermatology. 2013. V. 14. Iss. 1. P. 27-47.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Gynecology: textbook. Ed. by V.E. Radzinksy, A.M. Fuks. GEOTAR-Media, 2015. P. 460.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Liu G., Cao F., Zhao M. et al. Associations between HLA-A\B\DRB1 polymorphisms and risks of vulvar lichen sclerosus or squamous cell hyperplasia of the vulva. Genet. Mol. Res. 2015. V. 14. Iss. 4.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>McPherson T., Cooper S. Vulvar lichen sclerosus and lichen planus. Dermatologic Therapy. 2010. V. 23. P. 523-532.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Nair P. Dermatosis associated with menopause. Journal of Mid-Life Health. 2014. V. 5(4). P. 168-175.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Naylor E., Watson R., Sherratt M. Moleculaar aspects of skin ageing. Maturitas. 2011. V. 69. Iss. 3. P. 249-256.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Naswa S., Marfatia Y. Physician-administered clinical score of vulvar lichensclerosus: A study of 36 cases. Indian Journal of Sexually Transmitted Diseases. 2015. V. 36. Iss. 2. P. 174-177.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Novis C., Lima L., D’Acri A. et al. Disseminated lichen sclerosus in a child: a case report. Anais Brasileiros de Dermatologia. 2015. V. 90. Iss. 2. P. 283-284.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>New terminology of vulvar squamous intraepithelial lesions [electronic resource]. The XXIII World Congress. New York, 2015.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Oh J., Kim Y., Jung J. et al. Intrinsic aging- and photoaging - dependent level changes of glycosaminoglycans and their correlation with water content in human skin. Journal of Dermatological Science. 2011. Vol. 62. Iss. 3. P. 192-201.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Papakonstantinou E., Roth M., Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology. 2012. Vol. 4. Iss. 3. P. 253-258.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Brown L. Pathology of the vulva and vagina. Springer London, 2013. P. 1-11.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Salvatore S., Nappi R., Zerinati N. et al. A 12-week treatment with fractional CO2 laser for vulvovaginal atrophy: a pilot study. Climacteric. 2014. Vol. 17. Iss. 4.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Sandu C., Dumas M., Malan A. et al. Human skin keratinocytes, melanocytes, and fibroblasts contain distinct circadian clock machineries. Cellular and Molecular Life Sciences. 2012. Vol. 69. Iss. 19. P. 3329-3339.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Sikdar S., Papadopoulou M., Dubois J. What do we know about sulforaphane protection against photoaging? J. Cosmet. Dermatol. 2016.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Farage M., Miller K., Maibach H. Textbook of aging skin. Springer Berlin Heidelberg, 2010. P. 1127-1135.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Thornton J. Estrogens and aging skin. Dermato-Endocrinology. 2013. Vol. 5. Iss. 2. P. 264-270.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Van de Nieuwenhof H., Bulten J., Hollema H. Differentiated vulvar intraepithelial neoplasia is often found in lesions, previously diagnosed as lichen sclerosus, which have progressed to vulvar squamous cell carcinoma. Modern Pathology. 2011. Vol. 24. P. 297-305.</mixed-citation></ref></ref-list></back></article>
