RUDN Journal of MedicineRUDN Journal of MedicineВестник Российского университета дружбы народов. Серия: Медицина2313-02452313-0261Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)3340ArticlesСтатьиReview ArticleThe modern concept of the pathogenesis of chronic pelvic pain syndrome induced denomyosisСовременная концепция патогенеза синдрома хронической тазовой боли, индуцированной аденомиозомOrazovM RОразовМекан Рахимбердыевичomekan@mail.ruBikmaevaY RБикмаеваЯна Рявхатевнаbikmaeva90@mail.ruNovginovD SНовгиновДмитрий Сергеевичnovginov@mail.ruBabayevaE IБабаеваЭльвира Ильхамовнаelvira-3333@mail.ruAryutinD GАрютинДмитрий Геннадьевичarutin@mail.ruPeoples’ Friendship University of RussiaРоссийский университет дружбы народовClinical Hospital № 29Городская клиническая больница № 29150220162NO2 (2016)№2 (2016)12713207092016Copyright ©; 2016, Оразов М.Р., Бикмаева Я.Р., Новгинов Д.С., Бабаева Э.И., Арютин Д.Г.2016Оразов М.Р., Бикмаева Я.Р., Новгинов Д.С., Бабаева Э.И., Арютин Д.Г.http://creativecommons.org/licenses/by/4.0https://journals.rudn.ru/medicine/article/view/3340Chronic pelvic pain (CPP) is a significant public health problem affected women in the world. Although many pathologies are associated with CPP, the pain experienced is often disproportionate to the extent of disease identified and frequently no pathology is found (chronic pelvic pain syndrome). Adenomyosis - a pathological condition characterized by the presence of ectopic endometrial glands and stroma in the myometrium thickness combined with hyperplasia of muscle fibers [6]. The syndrome of chronic pelvic pain of endometriosis is one of the most urgent problems of modern gynecology [8]. The evidence reviewed in this paper demonstrates that CPP is associated with significant central changes women. Moreover, the presence of these changes has the potential to both exacerbate symptoms and to predispose these women to the development of additional chronic conditions.Синдром хронических тазовых болей является одной из актуальных проблем современной гинекологии. Одной из причин хронической тазовой боли (ХТБ) является аденомиоз. Формирование болевого синдрома при данном заболевании может быть обусловлено комбинацией трех механизмов: изменением нейрогуморальной регуляции; стимуляцией роста нервов и сосудов, воспалительным ремоделированием миометрия на фоне нарушения кровообращения и склерозирования сосудов, что в совокупности приводит к нарушению нейроиммунных отношений, предопределяющих повышение количества и сенситивности ноцицепторов на фоне хронического иммуновоспалительного процесса в эндометрии и миометрии. В связи с хронической тазовой болью данное заболевание является не только сложной медицинской, но и социально-экономической проблемой.adenomyosischronic pelvic pain syndromeаденомиозсиндром хронической тазовой боли[Abbott J., Hawe J., Hunter D. et al. Laparoscopic excision of endometriosis a randomized, plscebo-controlled trial. Fertil. Steril. 2014. Vol. 82. P. 878-884.][Brawn J., Morotti M., Zondervan K.T. et al. Central changes associated with chronic pelvic pain and endometriosis. Hum. Reprod. 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