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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">3317</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Genetic factors for development thrombophilia in pregnant</article-title><trans-title-group xml:lang="ru"><trans-title>Генетические факторы развития тромбофилии у беременных</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bondar</surname><given-names>T P</given-names></name><name xml:lang="ru"><surname>Бондарь</surname><given-names>Татьяна Петровна</given-names></name></name-alternatives><bio xml:lang="en">Кафедра физико-химических основ медицины,лабораторной диагностики и фармакологииМедико-биолого-химический факультет; Ставропольский государственный университет; Stavropol State University</bio><bio xml:lang="ru">Кафедра физико-химических основ медицины,лабораторной диагностики и фармакологииМедико-биолого-химический факультет; Ставропольский государственный университет</bio><email>sonu@live.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Muratova</surname><given-names>A Y</given-names></name><name xml:lang="ru"><surname>Муратова</surname><given-names>Анна Юрьевна</given-names></name></name-alternatives><bio xml:lang="en">Кафедра физико-химических основ медицины,лабораторной диагностики и фармакологииМедико-биолого-химический факультет; Ставропольский государственный университет; Stavropol State University</bio><bio xml:lang="ru">Кафедра физико-химических основ медицины,лабораторной диагностики и фармакологииМедико-биолого-химический факультет; Ставропольский государственный университет</bio><email>sonu@live.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Stavropol State University</institution></aff><aff><institution xml:lang="ru">Ставропольский государственный университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2012-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2012</year></pub-date><issue>1</issue><issue-title xml:lang="en">NO1 (2012)</issue-title><issue-title xml:lang="ru">№1 (2012)</issue-title><fpage>119</fpage><lpage>120</lpage><history><date date-type="received" iso-8601-date="2016-09-07"><day>07</day><month>09</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="ru">Copyright ©; 2012, Бондарь Т.П., Муратова А.Ю.</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Бондарь Т.П., Муратова А.Ю.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/3317">https://journals.rudn.ru/medicine/article/view/3317</self-uri><abstract xml:lang="ru">The results of studying the frequency of genetic polymorphism of receptor subunits platelet GP IIb/IIIa in 408 pregnant women.
It was found that in women with thrombophilia normal variant of the gene occurred in 63.6%, heterozygous mutation - in 21%, homozygous mutation - in 15,2% of cases. In healthy women heterozygous mutation was revealed in 15,7%, normal genotype - in 84,3% and homozygous mutations was not detected at all. The connection between the occurrence of clinical manifestations of thrombophilia and the presence of hetero- and homozygous mutations of the subunits of platelet receptor GP IIb/IIIa was shown.</abstract><kwd-group xml:lang="en"><kwd>pregnant women</kwd><kwd>thrombophilia</kwd><kwd>platelets</kwd><kwd>polymorphisms of thrombocyte receptors GP IIb/IIIa gene</kwd></kwd-group></article-meta></front><body></body><back><ref-list/></back></article>
