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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">32993</article-id><article-id pub-id-type="doi">10.22363/2313-0245-2022-26-4-396-403</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>GINECOLOGY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Рrediction of infertility in patients with uterine leiomyoma</article-title><trans-title-group xml:lang="ru"><trans-title>Прогнозирование бесплодия у пациенток с лейомиомой матки</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0582-3618</contrib-id><name-alternatives><name xml:lang="en"><surname>Semyatov</surname><given-names>Said M.</given-names></name><name xml:lang="ru"><surname>Семятов</surname><given-names>С. М.</given-names></name></name-alternatives><email>Lemin.leffad@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6816-3314</contrib-id><name-alternatives><name xml:lang="en"><surname>Leffad</surname><given-names>Lemin M.</given-names></name><name xml:lang="ru"><surname>Леффад</surname><given-names>М. Л.</given-names></name></name-alternatives><email>Lemin.leffad@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">City Clinical Hospital № 64</institution></aff><aff><institution xml:lang="ru">Городская клиническая больница № 64</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Peoples’ Friendship University of Russia</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-12-23" publication-format="electronic"><day>23</day><month>12</month><year>2022</year></pub-date><volume>26</volume><issue>4</issue><issue-title xml:lang="en">GINECOLOGY</issue-title><issue-title xml:lang="ru">ГИНЕКОЛОГИЯ</issue-title><fpage>396</fpage><lpage>403</lpage><history><date date-type="received" iso-8601-date="2022-12-23"><day>23</day><month>12</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Semyatov S.M., Leffad L.M.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Семятов С.М., Леффад М.Л.</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Semyatov S.M., Leffad L.M.</copyright-holder><copyright-holder xml:lang="ru">Семятов С.М., Леффад М.Л.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/32993">https://journals.rudn.ru/medicine/article/view/32993</self-uri><abstract xml:lang="en"><p style="text-align: justify;">Infertility is an important socio-economic problem due to the fact that planned childbearing occurs much later than three decades ago. In recent years, more attention has been paid to the role of uterine leiomyoma in the development of infertility. Uterine leiomyoma is a benign monoclonal, well-demarcated encapsulated tumor originating from the smooth muscle cells of the cervix or body of the uterus. Uterine leiomyoma is the most common uterine tumor in the reproductive age group, affecting 20-50 % of women. With conceptual changes in marriage and childbearing, the number of women over 35 with leiomyoma who want to have children has also increased significantly. The need to treat submucosal fibroids is widely recognized, but fibroids of other locations and sizes remain a clinical mystery. The purpose of the literature review was to determine the role of uterine fibroids in predicting infertility. It has been established that the incidence of uterine leiomyoma in women of reproductive age is on average about 40 %, infertility associated with this pathology occurs in 5-10 % of women. In 10 % of cases of infertility, uterine leiomyoma is the only established cause of infertility. Uterine leiomyoma is common among women of reproductive age, and as women continue to delay childbearing, an increasing number of patients will require fertility-preserving treatment options. Leiomyoma affects not only fertility but also obstetric outcomes. Women with intramural fibroids without cavity deformity have a 21 % reduction in live birth rates after in vitro fertilization compared with controls without fibroids. Despite advances in fundamental understanding of the biology of leiomyomas, the role of different fibroid variants remains a matter of discussion. The question of the negative impact of submucosal nodes on infertility today is not in doubt, and the effect of subserous and intramural nodes requires further study.</p></abstract><trans-abstract xml:lang="ru"><p style="text-align: justify;">Бесплодие является важной социально-экономической проблемой, в связи с тем что запланированное деторождение происходит гораздо позже, чем три десятилетия назад. В последние годы все больше внимания уделяется роли лейомиомы матки в развитии бесплодия. Лейомиома матки - д оброкачественная моноклональная, хорошо отграниченная капсулированная опухоль, происходящая из гладкомышечных клеток шейки или тела матки. Лейомиома матки является наиболее распространенной опухолью матки в репродуктивной возрастной группе, поражающей 20-50 % женщин. С концептуальными изменениями в вопросах брака и деторождения число женщин старше 35 лет с лейомиомой, желающих иметь детей, также значительно увеличилось. Необходимость лечения подслизистых миом широко признана, но миомы других локализаций и размеров продолжают представлять собой клиническую загадку. Целью литературного обзора являлось определение роли миомы матки при прогнозировании бесплодия. Выводы. Установлено, что частота встречаемости лейомиомы матки у женщин репродуктивного возраста составляет в среднем около 40 %, бесплодие ассоциированной с данной патологией встречается у 5-10 % женщин. В 10 % случаев бесплодия лейомиома матки является единственной установленной причиной бесплодия. Лейомиома матки широко распространена среди женщин репродуктивного возраста, и поскольку, женщины продолжают откладывать деторождение, все большему числу пациентов потребуются варианты лечения, сохраняющие фертильность. Лейомиома влияет не только на фертильность, а также на акушерские исходы. У женщин с интрамуральными миомами без деформации полостей наблюдается снижение частоты живорождения на 21 % после экстракорпорального оплодотворения по сравнению с контрольной группой без миомы. Несмотря на прогресс, достигнутый в фундаментальном понимании биологии лейомиомы, роль различных вариантов миом остается предметом для дискуссии. Вопрос об отрицательном влиянии субмукозных узлов на бесплодие на сегодняшний день не вызывает сомнений, а влияние субсерозных и интрамуральных узлов требуют дальнейшего изучения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>uterine leiomyoma</kwd><kwd>infertility</kwd><kwd>prediction</kwd><kwd>risk factors</kwd><kwd>submucosal</kwd><kwd>subserous</kwd><kwd>intramural nodes</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>лейомиома матки</kwd><kwd>бесплодие</kwd><kwd>прогнозирование</kwd><kwd>факторы риска</kwd><kwd>субмукозные</kwd><kwd>субсерозные</kwd><kwd>интрамуральные узлы</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Female infertility. Modern approaches to diagnosis and treatment. Clinical guidelines. 2021. Ministry of Health of the Russian Federation. 81 p. (In Russian).</mixed-citation><mixed-citation xml:lang="ru">Женское бесплодие (современные подходы к диагностике и лечению). Клинические рекомендации. 2021. Министерство здравоохранения РФ. 81 с.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Uterine fibroids. Clinical guidelines. 2020. Ministry of Health of the Russian Federation. 48 p. (In Russian).</mixed-citation><mixed-citation xml:lang="ru">Миома матки. Клинические рекомендации. Министерство здравоохранения РФ. 2020. 48 с.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><mixed-citation>Purohit P, Vigneswaran K. Fibroids and Infertility. Current obstetrics and gynecology reports. 2016;5:81-88. doi: 10.1007/s13669-016-0162-2</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Sevostyanova O, Lisovskaya T, Chistyakova G, Kiseleva M, Sevostyanova N, Remizova I, Buev Y. Proinflammatory mediators and reproductive failure in women with uterine fibroids. Gynecol Endocrinol. 2020;36:33-35. doi: 10.1080/09513590.2020.1816726</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Olive DL, Pritts EA. Fibroids and reproduction. Semin Reprod Med. 2010;28(3):218-27.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Al-Hendy A, Myers ER, Stewart E. Uterine Fibroids: Burden and Unmet Medical Need. Semin Reprod Med. 2017;35 (6):473-480. doi: 10.1055/s-0037-1607264</mixed-citation></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Badmaeva SJ, Tschay VB, Grigoriyn ES, Polstynaya GN. Uterine fibroids: modern aspects of etiology and pathogenesis (literature review). Mat’ I ditya v Kuzbasse. 2019;76(1):4-9. (In Russian).</mixed-citation><mixed-citation xml:lang="ru">Бадмаева С.Ж., Цхай В.Б., Григорян Э.С., Полстяная Г.Н. Миома матки: современные аспекты этиологии и патогенеза // Мать и Дитя. 2019. T. 76. № 1. С. 4-9.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><mixed-citation>Ciebiera M, Włodarczyk M, Słabuszewska-Jóźwiak A, Nowicka G, Jakiel G. Influence of vitamin D and transforming growth factor β3 serum concentrations, obesity, and family history on the risk for uterine fibroids. Fertil Steril. 2016;106(07):1787-1792. doi: 10.1016/j.fertnstert.2016.09.007</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Donnez J, Dolmans MM. Uterine fibroid management: from the present to the future. Hum Reprod Update. 2016;22(6):665-686. doi: 10.1093/humupd/dmw023</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Kim, JJ, Sefton, EC. The role of progesterone signaling in the pathogenesis of uterine leiomyoma. Molecular and cellular endocrinology. 2012;358(2):223-231. doi: 10.1016/j.mce.2011.05.044</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Stewart EA, Cookson CL, Gandolfo RA, Schulze-Rath R. Epidemiology of uterine fibroids: a systematic review. BJOG. 2017;124(10):1501-1512. doi: 10.1111/1471-0528.14640</mixed-citation></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">Tskhay VB, Grigoryan ES, Kostareva OV, Badmaeva SZ. Uterine fibroids and infertility: etiology, pathogenesis and modern treatment principles (literature review). Siberian Medical Review. 2019;(4):25-33 doi: 10.20333/2500136-2019-4-25-33. (In Russian).</mixed-citation><mixed-citation xml:lang="ru">Цхай В.Б., Григорян Э.С., Костарева О.В., Бадмаева С.Ж. Миома матки и бесплодие: этиология, патогенез, современные принципы лечения (обзор литературы) // Сибирское медицинское обозрение. 2019. № 4. C. 25-33.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">Tskhay VB, Schtoh EA. Uterine fibroids and women’s reproductive function. Communication Uterine fibroids with infertility. Obstetrics, Gynecology and Reproduction. 2014;8(4):42-47. (In Russian).</mixed-citation><mixed-citation xml:lang="ru">Цхай В.Б., Штох Е.А. миома матки и репродуктивная функция женщины. Связь миомы матки с бесплодием. Акушерство, Гинекология и Репродукция. 2014. T. 8. № 4. C. 42-47.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><mixed-citation>Middelkoop MA, Harmsen MJ, Manyonda I, Mara M, Ruuskanen A, Daniels J, Mol BWJ, Moss J, Hehenkamp WJK, Wu O. Uterine artery embolization versus surgical treatment in patients with symptomatic uterine fibroids: Protocol for a systematic review and meta-analysis of individual participant data. Eur J Obstet Gynecol Reprod Biol. 2021; 256: 179-183. DOI: 10.1016/j.ejogrb.2020.11.027</mixed-citation></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">Tolibova GKh. Pathogenetic determinants of endometrial dysfunction in patients with myoma. Journal of Obstetrics and Women’s Diseases. 2018;67(1):65-72. doi: 10.17816/JOWD 67165-72 (In Russian).</mixed-citation><mixed-citation xml:lang="ru">Толибова Г.Х. Патогенетические детерминанты эндометриальной дисфункции у пациенток с миомой матки // Журнал акушерства и женских болезней. 2018. Т. 67. № 1. С. 65-72.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><mixed-citation>Carranza-Mamane B, Havelock J, Hemmings R. Prise en charge des fibromes utérins en présence d’une infertilité autrement inexpliquée. J Obstet Gynaecol Can. 2016;38(12S): S 597-S 608. doi: 10.1016/j.jogc.2016.09.066</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Munro MG. Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity. Fertil Steril. 2019;111(4):629-640. doi: 10.1016/j.fertnstert.2019.02.008</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Sohn GS, Cho S, Kim YM, Cho CH., Kim MR, Lee SR; Working Group of Society of Uterine Leiomyoma. Current medical treatment of uterine fibroids. Obstet Gynecol Sci. 2018.61(2):192-201. doi: 10.5468/ogs.2018.61.2.192</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Christopoulos G. Vlismas A. Salim R. Islam R. Trew G. Lavery S. Fibroids that do not distort the uterine cavity and IVF success rates: an observational study using extensive matching criteria. BJOG. 2017;124:615-621. doi: 10.1111/1471-0528.14362</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Styer AK, Jin S, Liu D, Wang B, Polotsky AJ, Christianson MS, Vitek W, Engmann L, Hansen K, Wild R, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Christy A, Diamond MP, Eisenberg E, Zhang H, Santoro N; National Institute of Child Health and Human Development Reproductive Medicine Network. Association of uterine fibroids and pregnancy outcomes after ovarian stimulation-intrauterine insemination for unexplained infertility. Fertil Steril. 2017;107(3):756-762.e3. doi: 10.1016/j.fertnstert.2016.12.012</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Yan L, Yu Q, Zhang YN, Guo Z, Li Z, Niu J, Ma J. Effect of type 3 intramural fibroids on in vitro fertilization-intracytoplasmic sperm injection outcomes: a retrospective cohort study. Fertil Steril. 2018;109(5):817-822.e2. doi: 10.1016/j.fertnstert.2018.01.007</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Van Heertum K, Barmat L. Uterine fibroids associated with infertility. Womens Health (Lond). 2014;10(6):645-53.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Sunkara SK., Khairy M, El-Toukhy T, Khalaf Y, Coomarasamy A. The effect of intramural fibroids without uterine cavity involvement on the outcome of IVF treatment: a systematic review and meta-analysis. Hum Reprod. 2010;25(2):418-29.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Vlahos NF, Theodoridis TD, Partsinevelos GA. Myomas and Adenomyosis: Impact on Reproductive Outcome. Biomed Res Int. 2017;2017:5926470. doi: 10.1155/2017/5926470</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Ikhena DE, Bulun SE. Literature Review on the Role of Uterine Fibroids in Endometrial Function. Reprod Sci. 2018;25(5):635- 643. doi: 10.1177/1933719117725827.</mixed-citation></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">Aganezov SS, Aganezova NV, Morotskaya AV, Ponomarenko KY. Endometrial receptivity in women with disoders in reproductive system. Journal of Obstetrics and Women’s Diseases. 2017;66(3):135- 142. doi: 10.17816/JOWD 663135-142. (In Russian).</mixed-citation><mixed-citation xml:lang="ru">Аганезов С.С., Аганезова Н.В., Мороцкая А.В., Пономаренко К.Ю. Рецептивность эндометрия у женщин с нарушениями репродуктивной функции // Журнал акушерства и женских болезней. 2017. Т. 66. № 3. C. 135-142.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><mixed-citation>The Practice Committee of the American Society for Reproductive Medicine. Current clinical irrelevance of luteal phase deficiency: a committee opinion. Fertil Steril. 2015.103(4):27-32. doi: 10.1016/j.fertn-stert.2014.12.128</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Pier BD, Bates GW. Potential causes of subfertility in patients with intramural fibroids. Fertility research and practice. 2015;1;12. doi: 10.1186/s40738-015-0005-2.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Supermaniam S, Thye WL. Intramural fibroid and fertility - to operate or not. Gynecol Pelvic Med. 2019;2:31. doi: 10.21037/ gpm.2019.11.01</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Navarro A, Bariani MV, Yang Q, Al-Hendy A. Understanding the Impact of Uterine Fibroids on Human Endometrium Function. Front Cell Dev Biol. 2021;9:633180. doi: 10.3389/fcell.2021.633180.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Justiz Vaillant AA, Qurie A. Interleukin. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Tagashira Y, Taniguchi F, Harada T, Ikeda A, Watanabe A, Terakawa N. Interleukin-10 attenuates TNF-alpha-induced interleukin-6 production in endometriotic stromal cells. Fertil Steril. 2009;91(5 Suppl):2185-92. doi: 10.1016/j.fertnstert.2008.04.052</mixed-citation></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">Posiseeva LV, Gerasimov AM, Petrova UL. Glycodelin in obstetric and gynecological practice: past, present and future. Russian Journal of Human Reproduction. 2020;26(3):11-22. (In Russian). doi 10.17116/repro20202603111.</mixed-citation><mixed-citation xml:lang="ru">Посисеева Л.В., Герасимов А.М., Петрова У.Л. Гликоделин в акушерско-гинекологической практике: прошлое, настоящее, будущее // Проблемы репродукции. 2020. 26(3):11-22. doi 10.17116/repro20202603111</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">Galimova EF, Akmadoulina GKh, Bouligin KV, Mochalov KC, Galimov CN. Glycodelin S in blood serum and ejaculate in idiopathic infertility. Medical immunology. 2015. Т. 17. С. 264. (In Russian).</mixed-citation><mixed-citation xml:lang="ru">Галимова Э.Ф., Ахмадуллина Г.Х., Булыгин К.В., Мочалов К.С., Галимов Ш.Н. Гликоделин S в сыворотке крови и эякуляте при идиопатическом бесплодии // Медицинская иммунология. 2015. Т. 17. С. 264.</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><mixed-citation>Farimani Sanoee M, Alizamir T, Faramarzi S, Saidijam M, Yadegarazari R, Shabab N, Rastgoo Haghi A, Alizadeh Z. Effect of myomectomy on endometrial glutathione peroxidase 3 (GPx3) and glycodelin mRNA expression at the time of the implantation window. Iran Biomed J. 2014;18(2):60-6. doi: 10.6091/ibj.1222.2013</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Borahay MA, Asoglu MR, Mas A, Adam S, Kilic GS, Al-Hendy A. Estrogen Receptors and Signaling in Fibroids: Role in Pathobiology and Therapeutic Implications. Reprod Sci. 2017;24(9):1235-1244. doi: 10.1177/1933719116678686</mixed-citation></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">Sukhikh GT, Osipyants AI, Maltseva LI, Smolina GR, Poloznikov AA, Muyzhnek EL, Kiselev VI. Abnormal hypermethylation of the HOXA10 and HOXA11 genes in infertility associated with chronic endometritis. Obstetrics and gynecology. 2015;12:69-74. (In Russian).</mixed-citation><mixed-citation xml:lang="ru">Cухих Г.Т., Осипьянц А.И., Мальцева Л.И., Смолина Г.Р., Полозников А.А., Муйжнек Е.Л., Киселев В.И. Аномальное гиперметилирование генов HOXА10 и HOXА11 при бесплодии, ассоциированном с хроническим эндометритом // Акушерство и гинекология. 2015. № 12. С. 69-74.</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><mixed-citation>Pier BD, Bates GW. Potential causes of subfertility in patients with intramural fibroids. Fertil Res Pract. 2015;1:12. doi: 10.1186/s40738-015-0005-2</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Rackow BW, Taylor HS. Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity. Fertil Steril. 2010;93(6):2027-2034. doi:10.1016/j.fertnstert.2008.03.029</mixed-citation></ref></ref-list></back></article>
