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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">32228</article-id><article-id pub-id-type="doi">10.22363/2313-0245-2022-26-3-243-258</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>PHYSIOLOGY OF STRESS INFLUENCES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ФИЗИОЛОГИЯ СТРЕССОРНЫХ ВОЗДЕЙСТВИЙ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Local hardware hypothermia influence on the physiological processes</article-title><trans-title-group xml:lang="ru"><trans-title>Влияние локальной аппаратной гипотермии на физиологические процессы организма</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7160-2023</contrib-id><name-alternatives><name xml:lang="en"><surname>Guseynov</surname><given-names>Nidjat A.</given-names></name><name xml:lang="ru"><surname>Гусейнов</surname><given-names>Н. А.</given-names></name></name-alternatives><email>nid.gus@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0886-9160</contrib-id><name-alternatives><name xml:lang="en"><surname>Hammouri</surname><given-names>Marina H.</given-names></name><name xml:lang="ru"><surname>Хаммори</surname><given-names>А. А.</given-names></name></name-alternatives><email>nid.gus@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3982-5512</contrib-id><name-alternatives><name xml:lang="en"><surname>Muraev</surname><given-names>Alexandr A.</given-names></name><name xml:lang="ru"><surname>Мураев</surname><given-names>А. А.</given-names></name></name-alternatives><email>nid.gus@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5458-0192</contrib-id><name-alternatives><name xml:lang="en"><surname>Ivanov</surname><given-names>Sergey Y.</given-names></name><name xml:lang="ru"><surname>Иванов</surname><given-names>С. Ю.</given-names></name></name-alternatives><email>nid.gus@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6440-6662</contrib-id><name-alternatives><name xml:lang="en"><surname>Lukianova</surname><given-names>Elena A.</given-names></name><name xml:lang="ru"><surname>Лукьянова</surname><given-names>Е. А.</given-names></name></name-alternatives><email>nid.gus@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8591-3746</contrib-id><name-alternatives><name xml:lang="en"><surname>Klimenko</surname><given-names>Anna S.</given-names></name><name xml:lang="ru"><surname>Клименко</surname><given-names>А. С.</given-names></name></name-alternatives><email>nid.gus@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3636-9091</contrib-id><name-alternatives><name xml:lang="en"><surname>Noeerazlighi</surname><given-names>Mohammad A.</given-names></name><name xml:lang="ru"><surname>Ноиразлиги</surname><given-names>М. А.</given-names></name></name-alternatives><email>nid.gus@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Peoples’ Friendship University of Russia</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-10-07" publication-format="electronic"><day>07</day><month>10</month><year>2022</year></pub-date><volume>26</volume><issue>3</issue><issue-title xml:lang="en">PHYSIOLOGY OF STRESS INFLUENCES</issue-title><issue-title xml:lang="ru">ФИЗИОЛОГИЯ СТРЕССОРНЫХ ВОЗДЕЙСТВИЙ</issue-title><fpage>243</fpage><lpage>258</lpage><history><date date-type="received" iso-8601-date="2022-10-07"><day>07</day><month>10</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Guseynov N.A., Hammouri M.H., Muraev A.A., Ivanov S.Y., Lukianova E.A., Klimenko A.S., Noeerazlighi M.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Гусейнов Н.А., Хаммори А.А., Мураев А.А., Иванов С.Ю., Лукьянова Е.А., Клименко А.С., Ноиразлиги М.А.</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Guseynov N.A., Hammouri M.H., Muraev A.A., Ivanov S.Y., Lukianova E.A., Klimenko A.S., Noeerazlighi M.A.</copyright-holder><copyright-holder xml:lang="ru">Гусейнов Н.А., Хаммори А.А., Мураев А.А., Иванов С.Ю., Лукьянова Е.А., Клименко А.С., Ноиразлиги М.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/32228">https://journals.rudn.ru/medicine/article/view/32228</self-uri><abstract xml:lang="en"><p style="text-align: justify;">Relevance. Cold vasodilation is a response to a decrease in local and general temperature. Dose-controlled hypothermia is a therapeutic method for treating various pathological processes. Materials and Methods. In our study, we analyzed various indicators of the general condition of the human body under the influence of local controlled hypothermia. The study involved 25 healthy volunteers from the age of 21 to 34, including 14 males and 11 females. The study was carried out at a constant temperature of 25 ºС, relative humidity of 30 ± 5%, and an atmospheric pressure of 765mm Hg in silence and moderate illumination. The instruments of these indicators were bio-impedancemetry, angioscanning, as well as general thermometry. We also performed local thermometry of the buccal mucosa to identify temperature correlations between local hypothermia and buccal mucosa temperature. Local сontrolled hypothermia of the face was carried out by applying an elastic mask to the subject’s face. The mask had a system of irrigation tubes connected to the «ViTherm» device, which cooled the liquid and maintained its circulation. Due to the circulation of the cooled liquid in the mask the face was cooled. The mask covered the parotid-chewing, buccal, zygomatic, and infraorbital regions on the right and left. LCG lasted 50 minutes, and the circulating fluid temperature was 18 ºС. Results and Discussion. The effect of local controlled hypothermia at 18-20 °C did not affect vital signs in healthy adults: active cell mass, electrical reactance, extracellular fluid, oxygen saturation, the duration of systole. pulse. general temperature. At the same time, a decrease in tissue hydration was recorded. The revealed physiological effect of local hypothermia justifies using this temperature regime to reduce postoperative edema. Conclusion. Due to the absence of negative effects of local controlled hypothermia on the vital signs of the human body, the development and application of this tool in clinical practice, including the dental surgeon. is relevant.</p></abstract><trans-abstract xml:lang="ru"><p style="text-align: justify;">Актуальность. Холодовая вазодилятация является ответной реакцией на снижение температуры как локальной, так и общей. Дозированная контролируемая гипотермия является терапевтическим методом лечения различных патологических процессов. Материалы и методы. В нашем исследовании мы проанализировали различные показатели общего состояния организма человека под воздействием локальной контролируемой гипотермии. В исследовании участвовали здоровые добровольцы в количестве 25 человек, мужского (14) и женского (11) пола в возрасте от 21 до 34 лет. Исследование проводили в кабинете при постоянной температуре 25 ºС, относительной влажности 30 ± 5 %, атмосферном давлении 765 мм рт. ст., в тишине и умеренной освещенности. Инструментами оценки являлись биоимпедансиметрия, ангиосканирование, а также общая термометрия. Также была проведена локальная термометрия слизистой оболочки щеки для выявления температурных корреляций между локальной гипотермией и температурой слизистой щеки. Локальная контролируемая гипотермия лица проводилась наложением упруго-эластичной маски на лицо испытуемого, охлаждающему жидкость и поддерживающему ее циркуляцию аппаратом ViTherm. За счет циркуляции охлажденной жидкости в маске, происходило охлаждение лица. Маска перекрывала околоушно-жевательную, щечную. скуловую и подглазничные области справа и слева. Локальная контролируемая гипотермия длилась 50 минут, температура циркулирующей жидкости составляла 18 ºС. Результаты и обсуждение. Нами было выявлено, что воздействие локальная контролируемая гипотермия 18-20 ºС не изменяло основных показателей жизнедеятельности у здоровых людей: активная клеточная масса, реактивное сопротивление, внеклеточная жидкость, насыщенность кислородом, длительность систолы, пульс, общая температура. При этом было зарегистрировано снижение гидратации тканей. Выявленное физиологическое влияние локальной гипотермии обосновывает использование данного температурного режима для снижения послеоперационных отеков. Выводы. В силу отсутствия отрицательных эффектов локальной контролируемой гипотермии на показатели жизнедеятельности организма человека, актуальна разработка и применения данного инструмента в клинической практике, в том числе хирурга стоматолога.</p></trans-abstract><kwd-group xml:lang="en"><kwd>local hypothermia</kwd><kwd>bio-impedancemetry</kwd><kwd>angioscanning</kwd><kwd>thermometry</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>локальная гипотермия</kwd><kwd>биоимпедансометрия</kwd><kwd>ангиосканирование</kwd><kwd>термометрия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Keramidas ME, Kölegård R, Mekjavic IB, Eiken O. Interactions of mild hypothermia and hypoxia on finger vasoreactivity to local cold stress. Am J Physiol Regul Integr Comp Physiol. 2019;317(3): R 418-R 431. doi:10.1152/ajpregu.00103.2019</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Kounalakis SN, Keramidas ME, Amon M, Eiken O, Mekjavic IB. A 10-day confinement to normobaric hypoxia impairs toe. but not finger temperature response during local cold stress. J Therm Biol. 2017;64:109-115. doi:10.1016/j.jtherbio.2017.01.009</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Keramidas ME, Kölegård R, Eiken O. In Shackleton’s trails: Central and local thermoadaptive modifications to cold and hypoxia after a man-hauling expedition on the Antarctic Plateau. J Therm Biol. 2018;73:80-90. doi:10.1016/j.jtherbio.2018.02.010</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Cheung SS, Daanen HA. Dynamic adaptation of the peripheral circulation to cold exposure. Microcirculation. 2012;19(1):65-77. doi:10.1111/j.1549-8719.2011.00126.x</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Flouris AD, Cheung SS. Influence of thermal balance on cold-induced vasodilation. J Appl Physiol (1985). 2009;106(4):1264-1271. doi:10.1152/japplphysiol.91426.2008</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Hodges GJ, Mallette MM, Cheung SS. Cutaneous neural activity and endothelial involvement in cold-induced vasodilatation. Eur J Appl Physiol. 2018;118(5):971-978. doi:10.1007/s00421-018-3832-0</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Keatinge WR. The effect of low temperatures on the responses of arteries to constrictor drugs. J Physiol. 1958;142:395-405 doi:10.1113/jphysiol. 1958.sp006025</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Bergersen TK, Hisdal J, Walløe L. Perfusion of the human finger during cold-induced vasodilatation. Am J Physiol. 1999;276(3): R 731-R 737. doi:10.1152/ajpregu.1999.276.3.R 731</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Caldwell JN, Matsuda-Nakamura M, Taylor NA. Interactions of mean body and local skin temperatures in the modulation of human forearm and calf blood flows: a three-dimensional description. Eur J Appl Physiol. 2016;116(2):343-352. doi:10.1007/s00421-015-3288-4</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Lewis T. Observations upon the reactions of the vessels of the human skin to cold. Heart.1930;1915:177-208.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Sendowski I, Savourey G, Besnard Y, Bittel J. Cold induced vasodilatation and cardiovascular responses in humans during cold water immersion of various upper limb areas. Eur J Appl Physiol Occup Physiol. 1997;75(6):471-477. doi:10.1007/s004210050191</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Edwards MA. The role of arteriovenous anastomoses in cold-induced vasodilation. rewarming. and reactive hyperemia as determined by 24Na clearance. Can J Physiol Pharmacol. 1967;45(1):39-48. doi:10.1139/y67-004</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Grant RT, Bland EF. Observation on arteriovenous anastomoses in human skin and in the bird’s foot with special reference to the reaction to cold. Heart.1931;15:385-411.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Bergersen TK, Eriksen M, Walløe L. Local constriction of arteriovenous anastomoses in the cooled finger. Am J Physiol. 1997;273(3 Pt 2): R 880-R 886. doi:10.1152/ajpregu.1997.273.3.R 880</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Bini G, Hagbarth KE, Hynninen P, Wallin BG. Thermoregulatory and rhythm-generating mechanisms governing the sudomotor and vasoconstrictor outflow in human cutaneous nerves. J Physiol. 1980;306:537-552. doi:10.1113/jphysiol.1980.sp013413</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Lossius K, Eriksen M, Walløe L. Thermoregulatory fluctuations in heart rate and blood pressure in humans: effect of cooling and parasympathetic blockade. J Auton Nerv Syst. 1994;47(3):245-254. doi:10.1016/0165-1838(94)90185-6</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Ogino MH, Tadi P. Neuroanatomy, Trigeminal Reflexes. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2022. 326 p.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Millet JD, Brown RK, Levi B. Frostbite: Spectrum of Imaging Findings and Guidelines for Management. Radiographics. 2016;36(7):2154-2169. doi:10.1148/rg.2016160045</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>McLean DA. The use of cold and superficial heat in the treatment of soft tissue injuries. Br J Sports Med. 1989;23(1):53-54. doi:10.1136/bjsm.23.1.5320.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Hubbard TJ, Denegar CR. Does Cryotherapy Improve Outcomes With Soft Tissue Injury? J Athl Train. 2004;39(3):278-279.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Zachariassen KE. Hypothermia and cellular physiology. Arctic Med Res. 1991;50(Suppl 6):13-17.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Deal DN, Tipton J, Rosencrance E, Curl WW, Smith TL. Ice reduces edema. A study of microvascular permeability in rats. J Bone Joint Surg Am. 2002;84(9):1573-1578.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Possoff A. External thermal applications in postextraction therapy. J Am Dent Assoc. 1955;50(2):147-156. doi:10.14219/jada.archive.1955.0040</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Fouke JM, Wolin AD, Bowman HF, McFadden ER Jr. Effect of facial cooling on mucosal blood flow in the mouth in humans. Clin Sci (Lond). 1990;79(4):307-313. doi:10.1042/cs0790307</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Bierman W. The History of Fever Therapy in the Treatment of Disease. Bull N Y Acad Med. 1942;18(1):65-75.26.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Van der Westhuijzen AJ, Becker PJ, Morkel J, Roelse JA. A randomized observer blind comparison of bilateral facial ice pack therapy with no ice therapy following third molar surgery. Int J Oral Maxillofac Surg. 2005;34(3):281-286. doi:10.1016/j.ijom.2004.05.006</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Swantek PM, Crenshaw JD, Marchello MJ, Lukaski HC. Bioelectrical impedance: a nondestructive method to determine fat-free mass of live market swine and pork carcasses. J Anim Sci. 1992;70(1):169-177. doi:10.2527/1992.701169x</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Altmann M, Pliquett U, Suess R, von Borell E. Prediction of lamb carcass composition by impedance spectroscopy. J Anim Sci. 2004;82(3):816-825. doi:10.2527/2004.823816x</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Barbosa-Silva MCG, Barros AJD, Wang J, Heymsfield SB, Pierson RN Jr. Bioelectrical impedance analysis: population reference values for phase angle by age and sex. Am J Clin Nutr. 2005;82:49-52.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Nescolarde L, Piccoli A, Román A et al. Bioelectrical impedance vector analysis in haemodialysis patients: relation between oedema and mortality. Physiol Meas. 2004;25(5):1271-1280. doi:10.1088/0967-3334/25/5/016</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Maggiore Q, Nigrelli S, Ciccarelli C, Grimaldi C, Rossi GA, Michelassi C. Nutritional and prognostic correlates of bioimpedance indexes in hemodialysis patients. Kidney Int. 1996;50(6):2103-2108. doi:10.1038/ki.1996.535</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Pupim LB, Kent P, Ikizler TA. Bioelectrical impedance analysis in dialysis patients. Miner Electrolyte Metab. 1999;25(4-6):400-406. doi:10.1159/000057482</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>O’Brien JG, Chennubhotla SA, Chennubhotla RV. Treatment of edema. Am Fam Physician. 2005;71(11):2111-2117.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Gocoł R, Hudziak D, Bis J, Mendrala K, Morkisz Ł, Podsiadło P, Kosiński S, Piątek J, Darocha T. The Role of Deep Hypothermia in Cardiac Surgery. Int J Environ Res Public Health. 2021;1;18(13):7061. doi: 10.3390/ijerph18137061. PMID: 34280995; PMCID: PMC 8297075.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Jain V, Langham MC, Wehrli FW. MRI estimation of global brain oxygen consumption rate [published correction appears in J Cereb Blood Flow Metab. 2010 Dec;30(12):1987] [published correction appears in J Cereb Blood Flow Metab. 2011 May;31(5):1336]. J Cereb Blood Flow Metab. 2010;30(9):1598-1607. doi:10.1038/jcbfm.2010.49</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Norwood WI, Norwood CR. Influence of hypothermia on intracellular pH during anoxia. Am J Physiol. 1982;243(1):62-65. doi:10.1152/ajpcell.1982.243.1.C 62</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Jonas RA, Bellinger DC, Rappaport LA, Wernovsky G, Hickey PR, Farrell DM, Newburger JW. Relation of PH Strategy and Developmental Outcome after Hypothermic Circulatory Arrest. J. Thorac. Cardiovasc. Surg. 1993;106:362-368.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Mezrow CK, Midulla PS, Sadeghi AM, Gandsas A Wang W, Dapunt OE, Zappulla R, Griepp RB. Evaluation of Cerebral Metabolism and Quantitative Electroencephalography after Hypothermic Circulatory Arrest and Low-Flow Cardiopulmonary Bypass at Different Temperatures. J. Thorac. Cardiovasc. Surg. 1994;107:1006-1019.</mixed-citation></ref></ref-list></back></article>
