<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">3195</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Haemorrhagic dengue fever: a case report from Brazil</article-title><trans-title-group xml:lang="ru"><trans-title>Геморрагическая лихорадка Денге: клинический случай (Бразилия)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>R Micelle</surname><given-names>F N</given-names></name><name xml:lang="ru"><surname>Мисэлле</surname><given-names>Рианне Норонха</given-names></name></name-alternatives><bio xml:lang="en">Departament of Microbiology and Virology</bio><bio xml:lang="ru">Кафедра микробиологии и вирусологии</bio><email>sachivkina@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Leal</surname><given-names>S PB</given-names></name><name xml:lang="ru"><surname>Леал</surname><given-names>Сарах Баррос</given-names></name></name-alternatives><bio xml:lang="en">Faculty of Medicine</bio><bio xml:lang="ru">Медицинский факультет</bio><email>sarahbarrosleal@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Serpa</surname><given-names>JT S</given-names></name><name xml:lang="ru"><surname>Серпа</surname><given-names>Жозе Сильва</given-names></name></name-alternatives><bio xml:lang="en">Faculty of Medicine</bio><bio xml:lang="ru">Медицинский факультет</bio><email>thiefeson@hotmail.com</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sachivkina</surname><given-names>N P</given-names></name><name xml:lang="ru"><surname>Сачивкина</surname><given-names>Надежда Павловна</given-names></name></name-alternatives><bio xml:lang="en">Departament of Microbiology and Virology</bio><bio xml:lang="ru">Кафедра микробиологии и вирусологии</bio><email>sachivkina@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">People’s Friendship University of Russia</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Ceará Federal State University</institution></aff><aff><institution xml:lang="ru">Федералный Унивеситет Штата Сэара</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Maranhão Federal State University</institution></aff><aff><institution xml:lang="ru">Федеральный Университет Штата Маранао</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2014-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2014</year></pub-date><issue>1</issue><issue-title xml:lang="en">NO1 (2014)</issue-title><issue-title xml:lang="ru">№1 (2014)</issue-title><fpage>85</fpage><lpage>91</lpage><history><date date-type="received" iso-8601-date="2016-09-07"><day>07</day><month>09</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="ru">Copyright ©; 2014, Мисэлле Р.Н., Леал С.Б., Серпа Ж.С., Сачивкина Н.П.</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Мисэлле Р.Н., Леал С.Б., Серпа Ж.С., Сачивкина Н.П.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/3195">https://journals.rudn.ru/medicine/article/view/3195</self-uri><abstract xml:lang="en">Dengue fever (DF) is a common cause of arboviral infections in South America, belonging to the genus Flavivirus. Only in Fortaleza, the 5                  th most populated city in Brazil, in the year of 2011 over 110 cases of dengue fever by day were being registered [3]. DF is only rarely considered as a cause of acute liver failure [4], while this particular case involves three different systems, being the reason why it called our attention. 50 year old, male, conscious, presents to São José Hospital of Infectious Diseases with classic dengue fever symptoms, being the day of his admission the 9                  th since the first symptoms erupted. Other causes for acute hepatic failure like acute viral hepatitis, leptospirosis, malaria, Reyes syndrome were ruled out, had the patient already been tested for dengue IgM in a local hospital. Complained of a pain in his abdomen, simple thorax radiography showed an enlarged cardiac area. His ECG reinforced the cardiac enzymes’ results, showing a clear alteration in ventricular repolarization. Patient progressed with shock, cardiac insufficiency and ischemic hepatitis. With treatment for the multiple conditions he made a significant clinical and biochemical improvement. He was discharged after 33 days of hospital stay.</abstract><trans-abstract xml:lang="ru">Лихорадка денге (ЛД) является распространенной причиной арбовирусных инфекций в Южной Америке, принадлежащих к роду Flavovirus. Только в Форталезе, в 5-м по численности населения городе Бразилии, в 2011 году регистрировалось более 110 случаев заболевания лихорадкой денге в день [3]. Мужчина 50 лет, находящийся в сознании, поступил в Больницу Инфекционных Заболеваний Сао-Жозе с классическими симптомами лихорадки денге, на 9-й день от появления первых симптомов заболевания. ЛД редко рассматривается как причина острой печеночной недостаточности [4]. В данном описанном случае у больного наблюдалось поражение трех разных систем органов. У больного выявлены острая печеночная недостаточность, причиной которой был ишемический гепатит (такие ее причины, как острый вирусный гепатит, лептоспироз, малярия, синдром Рейеса были исключены), кардиомегалия и сепсис с явлениями септического шока. При лечении указанных осложнений наступило значительное улучшение клинической картины и биохимических показателей. После 33 дней пребывания в больнице больной был выписан из стационара.</trans-abstract><kwd-group xml:lang="en"><kwd>Dengue fever</kwd><kwd>Flavivirus</kwd><kwd>infectious diseases</kwd><kwd>viral hemorrhagic fevers</kwd><kwd>tropical diseases</kwd><kwd>brazil</kwd><kwd>case study</kwd><kwd>Aedes aegypti</kwd><kwd>Flavivirus</kwd><kwd>Aedes Aegypti</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>лихорадка Денге</kwd><kwd>инфекционные заболевания</kwd><kwd>вирусные геморрагические лихорадки</kwd><kwd>тропические болезни</kwd><kwd>Бразилия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Degallier N., Servain J., Lucio P.S., Hannart A., Durand B., de Souza R.N., Ribeiro Z.M. The influence of local environment on the aging and mortality of Aedes aegypti (L.): case study in Fortaleza-CE, Brazil // Journal of Vector Ecology. - 2013. - № 38. - P. 20-37.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Nunes J.S. Dengue: Etiologia, patogênese e suas implicações a nível global</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Fortaleza registra 110 casos de dengue por dia // Diário do Nordeste - 2011, September.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Sedhain A., Adhikari S., Regmi S., Chaudhari S.K., Shah M., Shrestha. Fulminant hepatic failure due to dengue // PubMed - 2011.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Dengue Diagnóstico e Manejo Clínico // Ministério da Saúde - 2011. - 4th ed.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Jean-Pierre Laissy, Fabien Hyafil, Laurent J. Feldman, Jean-Michel Juliar et al. Differentiating Acute Myocardial Infarction from Myocarditis: Diagnostic Value of Early- and Delayed-Perfusion Cardiac MR Imaging // Radiology - 2005, October - № 237 - P. 75-82.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Rosenthal D.S. Hematologic manifestations of infectious diseases // Hoffman R. eds. Hematology basic principles and practice - Orlando: Churchill Livingstone, 2000.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Maria Paula Gomes Mourão; Marcus Vinícius Guimarães de Lacerda; Michele de Souza Bastos et al. Dengue hemorrhagic fever and acute hepatitis: a case report // Braz J Infect Dis. - 2004, December. - 8 (6). - P. 461-464.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Jeffrey M. Testani, Daniel M. Kolansky, Harold Litt, Edward P. Gerstenfeld. Focal Myocarditis Mimicking Acute ST-Elevation Myocardial Infarction. Diagnosis Using Cardiac Magnetic Resonance Imaging // Tex Heart Inst J. - 2006; 33 (2). - P. 256-259.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>M.A. G.M. Olimulder, J. van Es, M.A. Galjee. The importance of cardiac MRI as a diagnostic tool in viral myocarditis-induced cardiomyopathy // Neth Heart J. 2009 December; 17 (12). - P. 481-486.</mixed-citation></ref></ref-list></back></article>
