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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">31075</article-id><article-id pub-id-type="doi">10.22363/2313-0245-2022-26-2-138-149</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>LARGE JOINTS ANATOMY AND PATHOLOGY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>АНАТОМИЯ И ПАТОЛОГИИ КРУПНЫХ СУСТАВОВ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Synovial microflora of large joints in patients of a multidisciplinary hospital</article-title><trans-title-group xml:lang="ru"><trans-title>Микрофлора синовии крупных суставов у пациентов многопрофильного стационара</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2386-355X</contrib-id><name-alternatives><name xml:lang="en"><surname>Schendrigin</surname><given-names>Ivan  N.</given-names></name><name xml:lang="ru"><surname>Щендригин</surname><given-names>И. Н.</given-names></name></name-alternatives><email>rhstav@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2567-2212</contrib-id><name-alternatives><name xml:lang="en"><surname>Podsvirova</surname><given-names>Irina  A.</given-names></name><name xml:lang="ru"><surname>Подсвирова</surname><given-names>И. А.</given-names></name></name-alternatives><email>rhstav@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Stavropol Regional Clinical Hospital</institution></aff><aff><institution xml:lang="ru">Ставропольская краевая клиническая больница</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-05-27" publication-format="electronic"><day>27</day><month>05</month><year>2022</year></pub-date><volume>26</volume><issue>2</issue><issue-title xml:lang="en">LARGE JOINTS ANATOMY AND PATHOLOGY</issue-title><issue-title xml:lang="ru">АНАТОМИЯ И ПАТОЛОГИИ КРУПНЫХ СУСТАВОВ</issue-title><fpage>138</fpage><lpage>149</lpage><history><date date-type="received" iso-8601-date="2022-05-27"><day>27</day><month>05</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Schendrigin I.N., Podsvirova I.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Щендригин И.Н., Подсвирова И.А.</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Schendrigin I.N., Podsvirova I.A.</copyright-holder><copyright-holder xml:lang="ru">Щендригин И.Н., Подсвирова И.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/31075">https://journals.rudn.ru/medicine/article/view/31075</self-uri><abstract xml:lang="en"><p style="text-align: justify;">Relevance. There is no doubt that microorganisms participate in occurrence and development of septic process in joints. However, the issue of etiological significance of each agent remains controversial, because, in spite of the general trends, indicating the participation of numerous microorganisms in the development of articular pathology, each result of microbiological analysis concerns only a specific case in the territorial and clinical aspects. The aim of the study - microbiological research of synovial fluid obtained from knee joint during synovitis after its aspiration in patients of various departments of the Stavropol Regional Clinical Hospital. Materials and Methods . There were studied 198 samples of synovial fluid. Primary inoculation of puncture was performed with subsequent isolation, identification of the cultures by mass spectrometry and assessment of their antibiotic sensitivity by discodiffusion method. Results and Discussion . 11 cultures of bacterial pathogens were isolated. Gram-positive cocci - 82 %, of which 77.8 % - microorganisms of Staphylococcus genus (44.4 % S.aureus , 33.4 % S.epidermidis ), 22.2 % - other gram-positive cocci: one strain of each, Enterococcus faecium and Streptococcus mitis . Gram-negative pathogens are represented by K.neumoniae and P.aeruginosa with a total content of 18 %. Highly virulent microorganisms S.aureus , K.neumoniae and P.aeruginosa are isolated from the synovial fluid of patients of the surgical departments (orthopedotraumatological No. 1, No. 2) and the rheumatological department. Microorganisms with low virulence E.faecium , S.mitis and S.epidermidis are isolated from synovial fluid of patients of various departments. No obvious resistance of isolated pathogens to antimicrobial drugs has been registered. Conclusion . The presence and species affiliation of the microorganisms identified in synovial fluid allows predicting their etiological significance in development of septic process in joints. Their role as causative agents of nosocomial infections typical for a medical institution is not excluded. The presence of articular pathology in each of the examined departments dictates the need for a clear understanding of the importance of timely and high-quality joint aspiration followed by microbiological examination in almost all patients with damage of large joints, including patients without clinical signs of septic arthritis. Such an approach that makes it possible to identify a greater number of causative agents of septic arthritis and quickly evaluate the dynamics of their antimicrobial resistance should become an obligatory part of a comprehensive research and treatment of a patient with arthritis in multi-fi eld hospitals.</p></abstract><trans-abstract xml:lang="ru"><p style="text-align: justify;">Актуальность. Не вызывает сомнения факт участия микроорганизмов в возникновении и развитии септического процесса в суставах. Однако вопрос об этиологической значимости каждого возбудителя остается дискуссионным, поскольку, несмотря на общие тенденции, свидетельствующие об участии многочисленных микроорганизмов в развитии суставной патологии, каждый результат микробиологического анализа касается лишь конкретного в территориальном и клиническом аспекте случая. Цель - проведение микробиологического исследования синовиальной жидкости, полученной при синовите коленного сустава после его аспирации у пациентов различных отделений Ставропольской краевой клинической больницы. Материалы и методы. Исследовались 198 образцов синовиальной жидкости. Проводился первичный посев пунктата с последующими выделением, идентификацией культур методом масс-спектрометрии и оценкой антибиотикочувствительности диско-д иффузионным методом. Результаты и обсуждение . Было выделено 11 культур бактериальных патогенов. Грамположительные кокки - 82 %, из которых 77,8 % - микроорганизмы рода Staphylococcus (44,4 % S.aureus , 33,4 % S.epidermidis ), 22,2 % - прочие грамположительные кокки: по одному штамму Enterococcus faecium и Streptococcus mitis . Грамотрицательные патогены представлены K.pneumoniae и P.aeruginosa с суммарной долей 18 %. Высоковирулентные микроорганизмы S.aureus , K.pneumoniae и P.aeruginosa выделены из синовиальной жидкости пациентов хирургических отделений (ортопедотравматологическое № 1, № 2) и ревматологического отделения. Микроорганизмы с низкой вирулентностью E.faecium , S.mitis и S.epidermidis выделены из синовиальной жидкости пациентов различных отделений. Выраженной резистентности выделенных патогенов к антимикробным препаратам не зарегистрировано. Выводы . Наличие и видовая принадлежность выявленных в синовиальной жидкости микроорганизмов позволяет прогнозировать их этиологическую значимость в развитии септического процесса в суставах. Не исключается их роль как возбудителей нозокомиальных инфекций, характерных для лечебного учреждения. Наличие суставной патологии в каждом из обследованных отделений диктует необходимость четкого понимания значимости проведения своевременной и качественной аспирации сустава с последующим микробиологическим исследованием практически у всех больных с поражением крупных суставов, в том числе у пациентов без клинических признаков септического артрита. Такой подход, позволяющий выявить большее число возбудителей септического артрита и оперативно судить о динамике их антимикробной резистентности, должен стать обязательной частью комплексного обследования и лечения пациента с артритом в многопрофильных стационарах.</p></trans-abstract><kwd-group xml:lang="en"><kwd>synovitis</kwd><kwd>septic arthritis</kwd><kwd>joint aspiration</kwd><kwd>synovial fluid</kwd><kwd>microbiological research</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>синовит</kwd><kwd>септический артрит</kwd><kwd>аспирация сустава</kwd><kwd>синовиальная жидкость</kwd><kwd>микробиологическое исследование</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Teplyakova OV, Rudnov VA, Shly`kova GI, Docenko TG. Septicheskij artrit u vzrosly`x. 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