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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">30535</article-id><article-id pub-id-type="doi">10.22363/2313-0245-2022-26-1-42-50</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Physiology</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Физиология</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Trace elements content in the hair of patients at the maxillofacial surgery department</article-title><trans-title-group xml:lang="ru"><trans-title>Содержание микроэлементов в волосах пациентов отделения челюстно-лицевой хирургии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6819-2067</contrib-id><name-alternatives><name xml:lang="en"><surname>Gedulyanov</surname><given-names>Marat T.</given-names></name><name xml:lang="ru"><surname>Гедулянов</surname><given-names>М. Т.</given-names></name></name-alternatives><email>lambrador2@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6476-7839</contrib-id><name-alternatives><name xml:lang="en"><surname>Kiyaeva</surname><given-names>Elena V.</given-names></name><name xml:lang="ru"><surname>Кияева</surname><given-names>Е. В.</given-names></name></name-alternatives><email>lambrador2@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Central Research Institute of Dentistry and Maxillofacial Surgery</institution></aff><aff><institution xml:lang="ru">Центральный научно-исследовательский институт стоматологии и челюстно-лицевой хирургии</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Orenburg State University</institution></aff><aff><institution xml:lang="ru">Оренбургский государственный университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-03-21" publication-format="electronic"><day>21</day><month>03</month><year>2022</year></pub-date><volume>26</volume><issue>1</issue><issue-title xml:lang="en">PHYSIOLOGY</issue-title><issue-title xml:lang="ru">ФИЗИОЛОГИЯ</issue-title><fpage>42</fpage><lpage>50</lpage><history><date date-type="received" iso-8601-date="2022-03-21"><day>21</day><month>03</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Gedulyanov M.T., Kiyaeva E.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Гедулянов М.Т., Кияева Е.В.</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Gedulyanov M.T., Kiyaeva E.V.</copyright-holder><copyright-holder xml:lang="ru">Гедулянов М.Т., Кияева Е.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/30535">https://journals.rudn.ru/medicine/article/view/30535</self-uri><abstract xml:lang="en"><p style="text-align: justify;">Relevance. The urgency of the problem of traumatism is constantly increasing, which is associated with an increase in road accidents, an increase in the number of interpersonal conflicts, the availability of firearms and cold steel weapon, etc. In addition, the proportion of victims with injuries of the maxillofacial region in a state of alcoholic intoxication is constantly growing. The aim of the study is to conduct a comparative analysis of trace elements in hospitalized patients with maxillofacial trauma, intoxicated, acute traumatic stress and the study of the effect of trauma on the balance of trace elements in patients of the Department of Maxillofacial Surgery with various alcohol history. Materials and Methods. The study involved 30 male patients of the department of maxillofacial surgery of the Moscow «city clinical F.I. Inozemtseva hospital located in the city of Moscow. All patients were joined to the department for trauma of the maxillofacial tract and were divided into two groups: 15 of them regularly took alcohol and were in a state of alcoholic intoxication at the time of injury (group 1), 15 - without alcohol history (comparison group 2). All patients carried a general clinical blood test, a biochemical blood test, and the content of essential and conditionally essential elements in the hair were also determined. Results and Discussion. As a result, significant differences were revealed in the content of micro elements between the groups of patients: the content of copper (p = 0.013) and zinc (p = 0.000) in the hair examined of the first group was 1.4 lower than in the comparison group 2. The manganese content (p = 0.05), on the contrary, was also increased by 1.4 times in the hair of group 1 patients. Besides, leukocytosis was detected in the blood in patients with a history of alcohol and an increase in AST levels. Conclusion. The study showed an increase in the content of manganese and a decrease in the content of selenium, zinc and copper in the hair of patients with an alcoholic history. Diselementosis was accompanied by a significant increase in aspartate aminotransferase activity, as well as leukocytosis and lymphocytosis. Such an imbalance of chemical elements, together with a changes of peripheral blood and an increase in the activity of ASaT, can be reflected on the period the timing and peculiarities of the course of the reparative process.</p></abstract><trans-abstract xml:lang="ru"><p style="text-align: justify;">Актуальность проблемы травматизма постоянно возрастает, что связано с ростом дорожно-транспортных происшествий, увеличением числа межличностных конфликтов, доступностью огнестрельного и холодного оружия и т.д., Кроме того, удельный вес пострадавших с травмами челюстно-лицевой области в состоянии алкогольного опьянения постоянно растет. Целью исследования явился сравнительный анализ микроэлементов госпитализированных пациентов с челюстно-лицевой травмой, находящихся в состоянии алкогольного опьянения, острого травматического стресса, и изучение влияния травмы на баланс микроэлементов у пациентов отделения челюстно-лицевой хирургии с различным алкогольным анамнезом. Материалы и методы. В исследовании приняли участие 30 пациентов мужского пола отделения челюстно-лицевой хирургии ГБУ здравоохранения города Москвы «Городская клиническая больница им. Ф.И. Иноземцева», расположенной в городе Москве. Все пациенты поступили в отделение по поводу травмы челюстно-лицевой области и были разделены на две группы: 15 из них систематически употребляли алкоголь и находились в состоянии алкогольного опьянения в момент получения травмы (1 группа), 15 - без алкогольного анамнеза (группа сравнения 2). Всем пациентам был проведен общий клинический анализ крови, биохимический анализ крови, а также определялось содержание эссенциальных и условно эссенциальных элементов в волосах. Результаты и обсуждение. В результате были выявлены достоверные отличия в содержании микроэлементов между группами пациентов: содержание меди (р=0.013) и цинка (р=0.000) в волосах обследованных первой группы было ниже в 1,4 по сравнению с группой сравнения 1.Содержание марганца (р=0.05), наоборот, оказалось повышенным в волосах пациентов 1 группы также в 1,4 раза. Кроме того, у пациентов с алкогольным анамнезом в крови был выявлен лейкоцитоз и повышение уровня АСТ. Выводы. Проведенное исследование показало повышение содержания марганца и снижение содержания селена, цинка и меди в волосах пациентов с алкогольным анамнезом. Дисэлементоз сопровождался достоверным повышением активности аспартатаминотрансферазы, а также лейкоцитозом и лимфоцитозом. Подобный дисбаланс химических элементов, в совокупности с изменением состава периферической крови и увеличением активности АСаТ, может отразиться на сроках и особенностях протекания репаративного процесса.</p></trans-abstract><kwd-group xml:lang="en"><kwd>traumatic stress</kwd><kwd>alcohol</kwd><kwd>trace elements</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>травматический стресс</kwd><kwd>алкоголь</kwd><kwd>микроэлементы</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Ajsuvakova OP, Tinkov AA, Aschner M, Rocha JBT, Michalke B, Skalnaya MG, Skalny AV, Butnariu M, Dadar M, Sarac I, Aaseth J, Bjørklund G. Sulfhydryl groups as targets of mercury toxicity. 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