RUDN Journal of MedicineRUDN Journal of MedicineВестник Российского университета дружбы народов. Серия: Медицина2313-02452313-0261Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)2543810.22363/2313-0245-2021-25-1-55-65CLINICAL AND EXPERIMENTAL PHYSIOLOGYЭКСПЕРИМЕНТАЛЬНАЯ И КЛИНИЧЕСКАЯ ФИЗИОЛОГИЯResearch ArticleOxidative stress correlates well with markers of metabolic syndrome in clinically hypothyroid cases: a hospital based study in a remote tribal districtКорреляция окислительного стресса с маркерами метаболического синдрома в клинических случаях гипотиреоза: исследование на базе больницы в отдаленном племенном районеPandaS.ПандаС.dr.suchismitapanda17@gmail.comDashManoj K.ДашМанодж К.dr.suchismitapanda17@gmail.comThatoiPravat K.ТатойПрават К.dr.suchismitapanda17@gmail.comDandapatJ.ДандапатД.dr.suchismitapanda17@gmail.comRathB.РатБ.dr.suchismitapanda17@gmail.comPandit Raghunath Murmu Medical CollegeМедицинский колледж Пандита Рагхунатха МурмуSriram Chandra Bhanj Medical CollegeМедицинский колледж Шрирама Чандры БханджаUtkal UniversityУткальский университетNorth Odisha UniversityУниверситет Норт-Одиша12012021251CORONAVIRUS INFECTION, INFECTIOUS DISEASESКОРОНАВИРУСНАЯ ИНФЕКЦИЯ, ИНФЕКЦИОННЫЕ БОЛЕЗНИ556512012021Copyright ©; 2021, Panda S., Dash M.K., Thatoi P.K., Dandapat J., Rath B.Copyright ©; 2021, Панда С., Даш М.К., Татой П.К., Дандапат Д., Рат Б.2021Panda S., Dash M.K., Thatoi P.K., Dandapat J., Rath B.Панда С., Даш М.К., Татой П.К., Дандапат Д., Рат Б.http://creativecommons.org/licenses/by/4.0https://journals.rudn.ru/medicine/article/view/25438

Relevance. Dislipidemia is one of the major manifestation of thyroid disease process due to alteration of metabolic parameters which are also seen in metabolic syndrome. Though oxidative stress has been implicated in both processes, controversial results have been obtained. Objective. To determine the status of lipid peroxidation product (Lpx) in the study group and identify the association of different components of metabolic syndrome. Material and Methods: 102 patients comprising of 60 healthy euthyroid controls and 42 hypothyroid patients served as the study group. Blood samples were collected for fasting blood sugar, renal parameters, lipid profile, tri-iodothyronin (T3), thyroxine (T4) and thyroid stimulating hormone (TSH). Level of lipid peroxidation in the samples was determined by monitoring the level of thiobarbituric acid like substances (TBARS) like substances. Results. The demographic parameters were significantly altered in hypothyroid patients. Systolic and diastolic blood pressure amongst both the groups was observed to have higher mean value in hypothyroid patients. The fasting blood sugar (FBS), total cholesterol, triacylglycerol, low density lipoprotein (LDL) and high density lipoprotein (HDL) in the hypothyroid was significantly higher than euthyroid control groups. The most frequent alteration in the hypothyroid patients was rise in SBP (95 %), Hypertriglyceridemia (50 %) and raised waist circumference (48 %) and DBP (42 %). A fourfold rise in Lpx was observed in hypothyroid subjects (p<0.001). Robust positive association was observed between TSH and Lpx. Multiple linear regressions revealed strongest and statistically significant association between serum serum thyroid stimulating hormone and waist circumference. Conclusion. The hypothyroid patients have significant higher degree of oxidative stress and the components of metabolic syndrome. They are the candidates for preventive health intervention.

Актуальность . Дислипидемия является одним из основных проявлений процесса заболевания щитовидной железы из-за изменения метаболических параметров, которые также наблюдаются при метаболическом синдроме. Хотя в оба процесса вовлечен окислительный стресс, результаты различных исследований достаточно противоречивые. Цель: определить статус продукта перекисного окисления липидов (Lpx) в исследуемой группе и выявить взаимосвязь различных компонентов метаболического синдрома. Материалы и методы. Группу исследования составили 102 пациента, из них 60 здоровых пациентов с эутиреоидным контролем и 42 пациента с гипотиреозом. Образцы крови были собраны для определения уровня сахара в крови натощак, параметров почек, липидного профиля, трийодтиронина (Т3), тироксина (Т4) и тиреотропного гормона (ТТГ). Уровень перекисного окисления липидов в образцах определяли путем мониторинга уровня веществ, подобных тиобарбитуровой кислоте, подобных веществ и дугим. Результаты. Демографические параметры были значительно изменены у пациентов с гипотиреозом. Было обнаружено, что систолическое и диастолическое артериальное давление в обеих группах имеет более высокое среднее значение у пациентов с гипотиреозом. Уровень сахара в крови натощак, общий холестерин, триацилглицерин, липопротеины низкой плотности и липопротеины высокой плотности в гипотиреозе были значительно выше, чем в контрольных группах с эутиреоидом. Наиболее частым изменением у пациентов с гипотиреозом было повышение САД (95 %), гипертриглицеридемия (50 %), увеличение окружности талии (48 %) и ДАД (42 %). У пациентов с гипотиреозом наблюдалось четырехкратное увеличение Lpx (p <0,001). Между ТТГ и перекисным окислением липидов наблюдалась стойкая положительная связь. Множественные линейные регрессии выявили сильнейшую и статистически значимую связь между тиреотропным гормоном сыворотки и окружностью талии. Выводы . Пациенты с гипотиреозом имеют значительно более высокую степень окислительного стресса и компонентов метаболического синдрома. Они являются кандидатами на профилактическое медицинское вмешательство.

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