RUDN Journal of MedicineRUDN Journal of Medicine2313-02452313-0261Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)2514Synthesis and anaigetical activity of derivatives of 1-indolilethil-3-pirrolin-2-onesDozmorovaN VPerm state pharmaceutical academysomvoz@live.ru <mailto:somvoz@live.ru>GeinV LPerm state pharmaceutical academysomvoz@live.ru <mailto:somvoz@live.ru>KasimovaN NPerm state pharmaceutical academysomvoz@live.ru <mailto:somvoz@live.ru>VarkentinL IPerm state pharmaceutical academysomvoz@live.ru <mailto:somvoz@live.ru>SyropyatovB YaPerm state pharmaceutical academysomvoz@live.ru <mailto:somvoz@live.ru>DanilovaN VPerm state pharmaceutical academysomvoz@live.ru <mailto:somvoz@live.ru>Perm state pharmaceutical academy15042009437838007092016Copyright © 2009,2009Interaction of methyl esters of acylpyruvic acides with mixture of aromatic aldehyde and tryptamine or 5-methoxytryptamine leads to 5-aryl-4-acyl-3-hydroxy-1-[2-(3-indolil)-ethyl)-2,5-dihydropyrrol-2-ones (I). The compounds (I) were transformed to 3,4-diaryl-1,4,5,6-tetrahydro-6-oxo-5-(2-(3-indolil)-ethyl)pyrrolo[3,4-c]pyrazoles (II) by reaction with hydrazine-hydrate. The structure of received compounds is established. The analgetical activity of compounds (I б-е) and (II) is investigated.tryptamineesters of acylpyruvic acides3-hydroxy-2,5-dihydropirrolin-2-onesanalgetical activityтриптаминэфиры ацилпировиноградных кислот3-гидрокси-2,5-дигидропиррол-2-оныанальгетическая активность