RUDN Journal of MedicineRUDN Journal of MedicineВестник Российского университета дружбы народов. Серия: Медицина2313-02452313-0261Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)2443410.22363/2313-0245-2020-24-3-201-206IMMUNOLOGYИММУНОЛОГИЯReview ArticlePhysiological and clinical aspects in COVID-19Физиологические и клинические аспекты COVID-19SatyanathR. KodidalaСатьянатхР. Кодидалаksatyanath1989@gmailSoroutJ.СороутДж.ksatyanath1989@gmailJayachandraS.ДжаячандраС.ksatyanath1989@gmailGandhiA.ГандиА.ksatyanath1989@gmailKackerS.КэкерС.ksatyanath1989@gmailKanti Devi Medical College, Hospital and Research CentreК.Д. Медицинский колледж, клиника и исследовательский центрZydus Medical College and HospitalМедицинский колледж ЗидусFaculty of Medicine and Health Science. S.G.T UniversityУниверситет Шри Гуру Гобинд СингхRUHS College Of Medical ScienceМедицинский колледж Рухс15122020243VOL 24, NO3 (2020)ТОМ 24, №3 (2020)20120626082020Copyright ©; 2020, Satyanath R.K., Sorout J., Jayachandra S., Gandhi A., Kacker S.Copyright ©; 2020, Сатьянатх Р.К., Сороут Д., Джаячандра С., Ганди А., Кэкер С.2020Satyanath R.K., Sorout J., Jayachandra S., Gandhi A., Kacker S.Сатьянатх Р.К., Сороут Д., Джаячандра С., Ганди А., Кэкер С.http://creativecommons.org/licenses/by/4.0https://journals.rudn.ru/medicine/article/view/24434There is a new public health crises threatening globally with the emergence and spread of 2019 novel corona virus (COVID-19) or the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). In very recent decade we have seen endemic outbreaks in the form of Middle East respiratory syndrome coronavirus (MERS CoV) and severe acute respiratory syndrome related coronavirus (SARS-CoV). Now we again see the emergence of another serious outbreak due to a new strain called the SARS-CoV-2 virus. This SARS-CoV-2 initially presented as pneumonia of unknown etiology with group of symptoms including fever, dry cough and shortness of breath in a cluster of patients in December 2019 Wuhan, China. COVID-19 now has quickly became a health emergency now across worldwide. SARS-CoV-2 is a newly emerging human infectious corona virus that causes COVID-19, now this has been recognized as a pandemic by the World Health Organization (WHO) on 11th March, 2020. Because of the pathogenesis and proliferation pathways of COVID-19 are still unknown the development of vaccine was not developed yet and definitive treatment was not implemented. Therefore, in this article, new potential COVID-19 therapies are briefly reviewed. The world is in emergent need for searching of possible medications for COVID-19.В мире возник новый кризис в области общественного здравоохранения, угрожающий появлением и распространением нового коронавируса 2019 г. (COVID-19), или коронавирусного тяжелого острого респираторного синдрома 2 (SARS-CoV-2). В последнее десятилетие мы наблюдали эндемические вспышки в виде коронавируса ближневосточного респираторного синдрома (MERS CoV) и коронавируса тяжелого острого респираторного синдрома (SARS-CoV). Теперь мы снова видим появление еще одной серьезной вспышки из-за нового штамма под названием вирус SARS-CoV-2. Этот вирус SARS-CoV-2 первоначально был представлен как пневмония неизвестной этиологии с симптомами, включающими жар, сухой кашель и одышку в группе пациентов в декабре 2019 в г. Ухань, Китай. COVID-19 быстро стал причиной чрезвычайной ситуации в области здравоохранения во всем мире. 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