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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">21282</article-id><article-id pub-id-type="doi">10.22363/2313-0245-2019-23-1-62-69</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>IMMUNOLOGY. ALLERGOLOGY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ИММУНОЛОГИЯ. АЛЛЕРГОЛОГИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS</article-title><trans-title-group xml:lang="ru"><trans-title>АЛЛЕРГИЧЕСКИЙ БРОНХОЛЕГОЧНЫЙ АСПЕРГИЛЛЕЗ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>D’Mello</surname><given-names>Rashmi</given-names></name><name xml:lang="ru"><surname>Д'Мелло</surname><given-names>Рашми</given-names></name></name-alternatives><email>SBahna@LSUHSC.edu</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kilaikode</surname><given-names>Sasikumar</given-names></name><name xml:lang="ru"><surname>Килайкод</surname><given-names>Сасикумар</given-names></name></name-alternatives><email>SBahna@LSUHSC.edu</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bahna</surname><given-names>Sami L.</given-names></name><name xml:lang="ru"><surname>Бахна</surname><given-names>Сами Л.</given-names></name></name-alternatives><email>SBahna@LSUHSC.edu</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff id="aff1"><institution>Allergy and Immunology Section, Louisiana State University Health Sciences Center</institution></aff><aff id="aff2"><institution>Pediatric Pulmonary Section, Louisiana State University Health Sciences Center</institution></aff><pub-date date-type="pub" iso-8601-date="2019-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2019</year></pub-date><volume>23</volume><issue>1</issue><issue-title xml:lang="en">VOL 23, NO1 (2019)</issue-title><issue-title xml:lang="ru">ТОМ 23, №1 (2019)</issue-title><fpage>62</fpage><lpage>69</lpage><history><date date-type="received" iso-8601-date="2019-06-12"><day>12</day><month>06</month><year>2019</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2019, D’Mello R., Kilaikode S., Bahna S.L.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2019, Д'Мелло Р., Килайкод С., Бахна С.Л.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="en">D’Mello R., Kilaikode S., Bahna S.L.</copyright-holder><copyright-holder xml:lang="ru">Д'Мелло Р., Килайкод С., Бахна С.Л.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/21282">https://journals.rudn.ru/medicine/article/view/21282</self-uri><abstract xml:lang="en"><p>Aspergillus is a saprophytic mold and its natural habitat is the soil. It is found worldwide indoors and outdoors in potted soil, compost, freshly cut grasses, decaying vegetation and in sewers. Aspergillus produces a bountiful number of spores and releases 2-3 micron sized spores into the air daily. It grows best at 37-40 °C, which is similar to the temperature in the lungs. These spores will remain airborne for a long period of time. It is estimated that humans inhale hundreds of spores daily. Several fungi other than aspergillus have been known to be implicated. Hence, the term allergic bronchopulmonary mycoses would be more appropriate unless the specific fungus is identified - which could be candida, helminthosporium, curvularia, bipolaris, cladosporium, or others. The review article is focused on the prototype allergic bronchopulmonary aspergillosis, its epidemiology, pathogenesis, diagnosis and treatment. Bronchopulmonary aspergillosis should be considered in patients with poorly controlled asthma despite appropriate routine therapy and environmental control. The need for frequent courses of corticosteroids with temporary improvement should raise the index of suspicion and appropriate evaluation be done. Early recognition and prompt initiation of appropriate corticosteroid treatment regimen would reduce the risk of development or progression of bronchiectasis and lung tissue damage. Regular follow up and monitoring serum total IgE level can predict exacerbations and should prompt corticosteroid treatment. Long term follow-up is important as relapses can occur years of remission.</p></abstract><trans-abstract xml:lang="ru"><p>Aspergillus является сапрофитной плесенью, его естественной средой обитания является почва. Он встречается по всему миру в помещениях и на открытом воздухе, в почве домашних растений, компосте, свежескошенных травах, гниющей растительности и в канализации. Aspergillus производит большое количество спор и выпускает споры размером 2-3 микрона в воздух ежедневно. Лучше всего растет при 37-40 °С, что соответствует температуре в легких. Эти споры остаются в воздухе в течение длительного периода времени. Подсчитано, что люди ежедневно вдыхают сотни спор. Известно, что заболевания вызывают не только Aspergillus, но и другие грибы. Следовательно, термин «аллергические бронхолегочные микозы» был бы более уместным, пока не идентифицирован конкретный гриб, который может быть кандидой, гельминтоспорием, куркулярией, биполирисом, кладоспорием или другими. Обзорная статья посвящена прототипу аллергического бронхолегочного аспергиллеза, его эпидемиологии, патогенезу, диагностике и лечению. Бронхолегочный аспергиллез возможен у пациентов с плохо контролируемой астмой, несмотря на соответствующую рутинную терапию и контроль окружающей среды. Раннее распознавание и своевременное начало соответствующей схемы лечения кортикостероидами уменьшит риск развития или прогрессирования бронхоэктазов и повреждения тканей легких. Регулярное наблюдение и мониторинг общего уровня IgE в сыворотке могут предсказать обострения и должны сопровождать терапию кортикостероидами. Важно долгосрочное наблюдение, поскольку рецидивы могут произойти через годы ремиссии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Allergic bronchopulmonary aspergillosis</kwd><kwd>allergic pulmonary mycosis</kwd><kwd>uncontrolled asthma</kwd><kwd>asthma</kwd><kwd>cystic fibrosis</kwd><kwd>bronchiectasis</kwd><kwd>aspergillus</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>аллергический бронхолегочный аспергиллез</kwd><kwd>аллергический легочный микоз</kwd><kwd>неконтролируемая астма</kwd><kwd>астма</kwd><kwd>муковисцидоз</kwd><kwd>бронхоэктаз</kwd><kwd>аспергиллез</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Centers for Disease Control and Prevention. Etymologia: Aspergillus. Emerg Infect Dis. 2006;12(3):415.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Lee J. Discovery of Aspergillus as a Human Pathogen. Retrieved January 15, 2019, from http://www.antimicrobe.org/ hisphoto/history/Aspergillus-Human%20Pathogens.asp.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Macartney JN. Pulmonary Aspergillosis: A Review and a Description of Three New Cases. Thorax. 1964;19(4): 287-297.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Hinson KF, Moon AJ, Plummer NS. Broncho-pulmonary aspergillosis; a review and a report of eight new cases. Thorax. 1952;7(4):317-333.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Latgé JP. Aspergillus fumigatus and Aspergillosis. Clin Microbiol Rev.1999; 12(2):310-350.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Knutsen AP, Slavin RG. Allergic bronchopulmonary aspergillosis in asthma and cystic fibrosis. Clin Dev Immunol. 2011;2011:843763:1-13.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Patterson K, Strek ME. Allergic Bronchopulmonary Aspergillosis. Proc Am Thorac Soc. 2010;7(3):237-44.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Tillie-Leblond I, Tonnel AB. Allergic bronchopulmonary aspergillosis. Allergy. 2005;60(8):1004-1013.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Amitani R, Kawanami R. Interaction of Aspergillus with human respiratory mucosa: a study with organ culture model. Med Mycol. 2009;47 Suppl 1:S127-131.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Kauffman HF, Tomee JF, van der Werf TS, de Monchy JG, Koeter GK. Review of fungus-induced asthmatic reactions. Am J Respir Crit Care Med. 1995;151(6): 2109-2116.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Garcia G, Humbert M, Capel F, et al. Chemokine receptor expression on allergen-specific T cells in asthma and allergic bronchopulmonary aspergillosis. Allergy. 2007; 62(2):170-177.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Miller PW, Hamosh A, Macek M, Jr., et al. Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in allergic bronchopulmonary aspergillosis. Am J Hum Genet. 1996;59(1):45-51.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Ueki S, Hebisawa A, Kitani M, Asano K, Neves JS. Allergic Bronchopulmonary Aspergillosis-A Luminal Hypereosinophilic Disease With Extracellular Trap Cell Death. Front Immunol. 2018;9(2346):1-9.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Douglass JA, Sandrini A, Holgate ST, O’Hehir RE. (2013). Allergic Bronchopulmonary Aspergillosis and Hypersensitivity Pneumonitis. In: N. Adkinson Jr, B. Bochner, A. Burks, W. Busse, S. Holgate, R. Lemanske, R. O'Hehir (Eds.), Middleton's Allergy Principles and Practice 8th edition: 2-Volume Set. (pp1000-1012). Philadelphia, PA: Elsevier Saunders.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Akuthota P, Weller P. (2017, June 29). Clinical manifestations and diagnosis of allergic bronchopulmonary aspergillosis - UpToDate. Retrieved January 15, 2019, from https://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-allergic-bronchopulmonary-aspergillosis? search=abpa&amp;source=search_result&amp;selectedTitle=1~51&amp;usage_type=default&amp;display_rank=1#H1248738776.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Agarwal R, Maskey D, Aggarwal AN, et al. Diagnostic Performance of Various Tests and Criteria Employed in Allergic Bronchopulmonary Aspergillosis: A Latent Class Analysis. PLoS One. 2013;8(4)e61105:1-7.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Shah A, Panjabi C. Allergic Bronchopulmonary Aspergillosis: A Perplexing Clinical Entity. Allergy Asthma Immunol Res. 2016;8(4):282-297.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Rosenberg M, Patterson R, Mintzer R, Cooper BJ, Roberts M, Harris KE. Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis. Ann Intern Med. 1977;86(4):405-414.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Greenberger PA. Allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol. 2002;110(5):685-692.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Agarwal R, Khan A, Gupta D, Aggarwal AN, Saxena AK, Chakrabarti A. An alternate method of classifying allergic bronchopulmonary aspergillosis based on high-attenuation mucus. PLoS One. 2010;5(12):e15346:1-9.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Agarwal R, Chakrabarti A, Shah A, et al. Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy. 2013;43(8):850-873.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Agarwal R, Aggarwal AN, Gupta D, Jindal SK. Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma: systematic review and meta-analysis. Int J Tuberc Lung Dis. 2009; 13(8):936-944.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Menzies D, Holmes L, McCumesky G, Prys-Picard C, Niven R. Aspergillus sensitization is associated with airflow limitation and bronchiectasis in severe asthma. Allergy. 2011;66(5):679-685.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Greenberger PA, Patterson R. Allergic bronchopulmonary aspergillosis. Model of bronchopulmonary disease with defined serologic, radiologic, pathologic and clinical findings from asthma to fatal destructive lung disease. Chest. 1987;91(6 Suppl):165s-171s.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Patterson R, Greenberger PA, Halwig JM, Liotta JL, Roberts M. Allergic bronchopulmonary aspergillosis. Natural history and classification of early disease by serologic and roentgenographic studies. Arch Intern Med. 1986;146(5):916-918.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Agarwal R, Gupta D, Aggarwal AN, Behera D, Jindal SK. Allergic bronchopulmonary aspergillosis: lessons from 126 patients attending a chest clinic in north India. Chest. 2006;130(2):442-448.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Limper AH, Knox KS, Sarosi GA, et al. An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients. Am J Respir Crit Care Med. 2011;183(1):96-128.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Agarwal R, Gupta D, Aggarwal AN, et al. Clinical significance of decline in serum IgE levels in allergic bronchopulmonary aspergillosis. Respir Med. 2010;104(2):204-210.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Stevens DA, Schwartz HJ, Lee JY, et al. A randomized trial of itraconazole in allergic bronchopulmonary aspergillosis. N Engl J Med. 2000;342(11):756-762.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Stevens DA, Moss RB, Kurup VP, et al. Allergic bronchopulmonary aspergillosis in cystic fibrosis-state of the art: Cystic Fibrosis Foundation Consensus Conference. Clin Infect Dis. 2003;37(Suppl 3):S225-264.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Patterson TF, Thompson GR, 3rd, Denning DW, et al. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;63(4):e1-e60.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Parmar JS, Howell T, Kelly J, Bilton D. Profound adrenal suppression secondary to treatment with low dose inhaled steroids and itraconazole in allergic bronchopulmonary aspergillosis in cystic fibrosis. Thorax. 2002;57(8):749-750.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Chishimba L, Niven RM, Cooley J, Denning DW. Voriconazole and posaconazole improve asthma severity in allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization. J Asthma. 2012;49(4):423-433.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Tillie-Leblond I, Germaud P, Leroyer C, et al. Allergic bronchopulmonary aspergillosis and omalizumab. Allergy. 2011;66(9):1254-1256.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Knutsen AP, Bush RK, Demain JG, et al. Fungi and allergic lower respiratory tract diseases. J Allergy Clin Immunol. 2012;129(2):280-291.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Tracy MC, Okorie CUA, Foley EA, Moss RB. Allergic Bronchopulmonary Aspergillosis. J Fungi (Basel). 2016; 2(2)17:1-18.</mixed-citation></ref></ref-list></back></article>
