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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Medicine</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Медицина</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-0245</issn><issn publication-format="electronic">2313-0261</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">18951</article-id><article-id pub-id-type="doi">10.22363/2313-0245-2018-22-2-141-147</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CARDIOLOGY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КАРДИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">MANIFESTATIONS OF FRAILTY IN ELDERLY PATIENTS WITH ACUTE CORONARY SYNDROME</article-title><trans-title-group xml:lang="ru"><trans-title>ПРОЯВЛЕНИЯ СИНДРОМА СТАРЧЕСКОЙ АСТЕНИИ У ПАЦИЕНТОВ СТАРЧЕСКОГО ВОЗРАСТА И ДОЛГОЖИТЕЛЕЙ С ОСТРЫМ КОРОНАРНЫМ СИНДРОМОМ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Soseliya</surname><given-names>N N</given-names></name><name xml:lang="ru"><surname>Соселия</surname><given-names>Н Н</given-names></name></name-alternatives><bio xml:lang="en"><p>post-graduate student of the Department of Internal Diseases with a course of cardiology and functional diagnostics named after academician V.S. Moiseev</p></bio><bio xml:lang="ru"><p>аспирант кафедры внутренних болезней с курсом кардиологии и функциональной диагностики имени академика В.С. Моисеева</p></bio><email>nini.soseliya@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bagmanova</surname><given-names>N K</given-names></name><name xml:lang="ru"><surname>Багманова</surname><given-names>Н Х</given-names></name></name-alternatives><email>nini.soseliya@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Villevalde</surname><given-names>S V</given-names></name><name xml:lang="ru"><surname>Виллевальде</surname><given-names>С В</given-names></name></name-alternatives><email>nini.soseliya@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kobalava</surname><given-names>Z D</given-names></name><name xml:lang="ru"><surname>Кобалава</surname><given-names>Ж Д</given-names></name></name-alternatives><email>nini.soseliya@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Peoples’ Friendship University of Russia (RUDN University)</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2018</year></pub-date><volume>22</volume><issue>2</issue><issue-title xml:lang="en">VOL 22, NO2 (2018)</issue-title><issue-title xml:lang="ru">ТОМ 22, №2 (2018)</issue-title><fpage>141</fpage><lpage>147</lpage><history><date date-type="received" iso-8601-date="2018-07-26"><day>26</day><month>07</month><year>2018</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Soseliya N.N., Bagmanova N.K., Villevalde S.V., Kobalava Z.D.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, Соселия Н.Н., Багманова Н.Х., Виллевальде С.В., Кобалава Ж.Д.</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Soseliya N.N., Bagmanova N.K., Villevalde S.V., Kobalava Z.D.</copyright-holder><copyright-holder xml:lang="ru">Соселия Н.Н., Багманова Н.Х., Виллевальде С.В., Кобалава Ж.Д.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/medicine/article/view/18951">https://journals.rudn.ru/medicine/article/view/18951</self-uri><abstract xml:lang="en"><p>Background. Frailty is a high-priority issue in cardiovascular medicine because of the aging of patients. It reflects the complex functional disorders and is associated with high morbidity and adverse outcomes. The aim of the study was to examination prevalence of frailty, its associations with mortality and hemorrhagic risk in elderly patients with ACS. Materials and methods. In 130 patients ≥ 75 years (82,7 ± 4,7 years, arterial hypertension (AH) 91,5%, previous myocardial infarction (MI) 32,3%, atrial fibrillation 32,3%, diabetes 26,9%, admitted with MI 75,4% or unstable angina 24,6%, frailty (national validated questionnaire), nutritional status (Mini Nutrition Assessment), cognitive function (Mini Mental State Examination) were assessed. Results. Mean score on a national validated questionnaire was 2,9 ± 1,4 points. Only 8.5% of patients responded negatively to all questionnaire questions. None of the patients had 7 points. 6,2, 19,2, 32,3, 23,8, 6,9 and 3,1% patients had 1, 2, 3, 4, 5 and 6 points. 8,5% of the patients were non-frail, 25,4% pre-frail and 66,1% frail. Patients with frailty were more likely women, had higher incidence of AH, MI in this hospitalization, GFR &lt; 60 ml/min/1,73 m2. Conclusion. Frailty occured in 66,1% of elderly patients with ACS, was associated with increased prevalence of cardiovascular diseases.</p></abstract><trans-abstract xml:lang="ru"><p>Наряду с увеличением выживаемости пациентов 75 лет и старше с сердечно-сосудистыми заболеваниями становится актуальным синдром старческой астении (ССА) в данной популяции. ССА ассоциируется с высокой частотой осложнений и неблагоприятным прогнозом и отражает комплекс функциональных изменений. Цель: оценка распространенности и ассоциации ССА при использовании валидированного скринингового опросника «Возраст не помеха». Материалы и методы. У 130 пациентов ≥ 75 лет, госпитализированных с ОКС (67,7% женщин, средний возраст 82,7 ± 4,7 лет, артериальная гипертония (АГ) 91,5%, инфаркт миокарда (ИМ) в анамнезе 32,3%, фибрилляция предсердий 32,3%, сахарный диабет 26,9%, ИМ в настоящую госпитализацию 75,4%, нестабильная стенокардия 24,6%) ССА оценен по скрининговому опроснику «Возраст не помеха». Оценивали когнитивные функции (Mini-Mental State Examination), питание (Mini Nutritional Assessment). Результаты. Средний балл по опроснику «Возраст не помеха» составил 2,9 ± 1,4 балла. На все вопросы ответили отрицательно только 8,5% пациентов. Ни один из пациентов не ответил положительно на все вопросы. 6,2, 19,2, 32,3, 23,8, 6,9 and 3,1% пациентов имели 1, 2, 3, 4, 5 и 6 баллов. У 66,1% пациентов диагностировали ССА, у 25,4% - предастеническое состояние, у 8,5% нарушений не было выявлено. Пациенты с ССА по сравнению с пациентами без ССА характеризовались большей частотой АГ и ИМ, диагностированного в настоящую госпитализацию, меньшей скоростью клубочковой фильтрациии (СКФ). Вывод: ССА встречается у 66,1% пациентов с ОКС старческого возраста и долгожителей, ассоциируется с большей частотой сердечно-сосудистых заболеваний.</p></trans-abstract><kwd-group xml:lang="en"><kwd>acute coronary syndrome</kwd><kwd>elderly</kwd><kwd>frailty</kwd><kwd>cognitive function</kwd><kwd>nutritional status</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>острый коронарный синдром</kwd><kwd>старческий возраст и долгожители</kwd><kwd>синдром старческой астении</kwd><kwd>гериатрические синдромы</kwd><kwd>когнитивные функции</kwd><kwd>статус питания</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Alexander KP, Newby LK, Armstrong PW, et al. 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