RUDN Journal of MedicineRUDN Journal of MedicineВестник Российского университета дружбы народов. Серия: Медицина2313-02452313-0261Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)1664610.22363/2313-0245-2017-21-2-259-269ArticlesСтатьиResearch ArticleRISK FACTORS AND ECHOCARDIOGRAPHIC DIAGNOSIS OF PULMONARY HYPERTENSION IN CHILDREN WITH BRONCHOPULMONARY DYSPLASIAФАКТОРЫ РИСКА И ЭХОКАРДИОГРАФИЧЕСКАЯ ДИАГНОСТИКА ЛЕГОЧНОЙ ГИПЕРТЕНЗИИ У ДЕТЕЙ С БРОНХОЛЕГОЧНОЙ ДИСПЛАЗИЕЙDegtyarevaE AДегтяреваЕ Аkonovalov_oe@rudn.universityOvsyannikovD YuОвсянниковД Ю

доктор медицинских наук, зав. каф. педиатрии Российского университета дружбы народов.

mdovsyannikov@yahoo.comZaitsevaN OЗайцеваН Оkonovalov_oe@rudn.universityShokinA AШокинА Аkonovalov_oe@rudn.universityRUDN University, Moscow, RussiaРоссийский университет дружбы народов, Москва, РоссияChildrens Infectious Diseases Hospital No. 6, Moscow, RussiaДетская инфекционная клиническая больница № 6, Москва, Россия15122017212VOL 21, NO2 (2017)ТОМ 21, №2 (2017)25926909092017Copyright ©; 2017, Degtyareva E.A., Ovsyannikov D.Y., Zaitseva N.O., Shokin A.A.Copyright ©; 2017, Дегтярева Е.А., Овсянников Д.Ю., Зайцева Н.О., Шокин А.А.2017Degtyareva E.A., Ovsyannikov D.Y., Zaitseva N.O., Shokin A.A.Дегтярева Е.А., Овсянников Д.Ю., Зайцева Н.О., Шокин А.А.http://creativecommons.org/licenses/by/4.0https://journals.rudn.ru/medicine/article/view/16646

Pulmonary hypertension and pulmonary heart are severe complications of broncho-pulmonary dysplasia, accompanied by poor prognosis and high mortality. Based on Doppler echocardio-graphy in 100 children with bronchopulmonary dysplasia, the frequency of pulmonary hypertension de-velopment and pulmonary heart formation was determined. The risk factors for these complications and mortality outcomes have been defined. The quantitative evaluation of the informative value of electro-cardiographic, radiographic, computer tomographic signs of pulmonary hypertension in children with bronchopulmonary dysplasia was performed. The correspondence of the functional classes of pulmonary hypertension in the Panamanian classification of hypertensive vascular lung disease in children (2011) to the degree of increase in systolic pressure in the pulmonary artery and the severity of hypoxemia was defined.

Легочная гипертензия и легочное сердце являются грозными осложнениями бронхолегочной дисплазии, сопровождаясь неблагоприятным прогнозом и высокой летальностью. На основании доп-плер-эхокардиографии у 100 детей с бронхолегочной дисплазией определены частота развития ле-гочной гипертензии и формирования легочного сердца. Установлены факторы риска данных ослож-нений и летального исхода. Количественно оценена информативность электрокардиографических, рентгенологических, компьютерно-томографических признаков легочной гипертензии у детей с бронхолегочной дисплазией. Установлено соответствие функциональных классов легочной гипер-тензии Панамской классификации гипертензивной сосудистой болезни легких у детей (2011) степени повышения систолического давления в легочной артерии и выраженности гипоксемии.

bronchopulmonary dysplasiapulmonary hypertensiondiagnosticsechocardiographyбронхолегочная дисплазиялегочная гипертензиядиагностикаэхокар-диографияNorthway W.H.Jr., Rosan R.C. & Porter D.Y. Pulmonary disease following respiratory therapy of hyaline membrane disease. Bronchopulmonary dysplasia. N Engl J Med. 1967. V. 276. N 7. P. 357—368.Northway W.H.Jr., Rosan R.C., Porter D.Y. Pulmonary disease following respiratory therapy of hyaline membrane disease. Bronchopulmonary dysplasia // N Engl J Med. 1967. V. 276. № 7. P. 357-368.Zarqa A., Schmidt P., Dodd J. & Jeppesen D.L. Predictors of bronchopulmonary dysplasia and pulmonary hypertension in newborn children. Dan Med J. 2013. V. 60. N 8. P. 4688.Zarqa A., Schmidt P., Dodd J., Jeppesen D.L. Predictors of bronchopulmonary dysplasia and pulmonary hypertension in newborn children // Dan Med J. 2013. V. 60. № 8. P. 4688.Slaughter J.R., Pakrashi T., Jones D.E. et al. Echocardiographic detection of pulmonary hyperten-sion in extremely low birth weight infants with bronchopulmonary dysplasia requiring prolonged positive pressure ventilation. J Perinatol. 2011. N 10. P. 35—40.Slaughter J.R., Pakrashi T., Jones D.E., et al. Echocardiographic detection of pulmonary hypertension in extremely low birth weight infants with bronchopulmonary dysplasia requiring prolonged positive pressure ventilation // J Perinatol. 2011. № 10. P. 35-40.Gewitz M.H. Cor pulmonale — Pulmonary heart disease. In: Emmanoulides G.C., Allen H.D., Riemenschneider T.A. & Gutgesel H.P. (eds): Moss and Adams’Heart Disease in Infants, Child¬ren and Adolescents, Icluding the Fetus and Young Adult, 5th ed. Baltimore, Williams & Wilkins, 1994: 345—68.Gewitz M.H. Cor pulmonale - Pulmonary heart disease. In: Emmanoulides G.C., Allen H.D., Riemenschneider T.A., Gutgesel H.P. (eds). Moss and Adams’Heart Disease in Infants, Children and Adolescents, Icluding the Fetus and Young Adult, 5 th ed. Baltimore: Williams & Wilkins. 1994. P. 345-68.Ovsyannikov D.Yu., Komleva N.A., Oboladze T.B. et al. Modern Algorithms for Diagnostics of Bronchopulmonary Dysplasia. Pediatric Diagnostics. 2011. V. 3. N 1. P. 12—20.Овсянников Д.Ю., Комлева Н.А., Оболадзе Т.Б. и др. Современные алгоритмы диагностики бронхолегочной дисплазии // Вопр. диагностики в педиатрии. 2011. V. 3. № 1. P. 12-20.Subhedar N.V. & Shaw N.J. Changes in pulmonary arterial pressure in preterm infants with chronic lung disease. Arch Dis Child Fetal Neonatal Ed. 2000. V. 82. N 3. P. F243—F247.Subhedar N.V., Shaw N.J. Changes in pulmonary arterial pressure in preterm infants with chronic lung disease // Arch Dis Child Fetal Neonatal Ed. 2000. V. 82. № 3. P. F243-F247.Fouron J.C., Le Guennec J.C., Villemant D. et al. Value of echocardiography in assessing the out-come of bronchopulmonary dysplasia of the newborn. Pediatrics. 1980. V. 65. N 3. P. 529—535.Fouron J.C., Le Guennec J.C., Villemant D. et al. Value of echocardiography in assessing the outcome of bronchopulmonary dysplasia of the newborn // Pediatrics. 1980. V. 65. № 3. P. 529-535.Khemani E., McElhinney D.B., Rhein L. et al. Pulmonary artery hypertension in formerly prema-ture infants with bronchopulmonary dysplasia: clinical features and outcomes in the surfactant era. Pediatrics. 2007. V. 120. N 6. P. 1260—1269.Khemani E., McElhinney D.B., Rhein L. et al. Pulmonary artery hypertension in formerly premature infants with bronchopulmonary dysplasia: clinical features and outcomes in the surfactant era // Pediatrics. 2007. V. 120. № 6. P. 1260-1269.Schert R.F. & Park S.A. Complications in infants with bronchopulmonary dysplasia. In Bron¬chopulmonary dysplasia: Strategies for Total Patient Care. Ed. by C.H. Lund. 1989. P. 48—73.Schert R.F., Park S.A. Complications in infants with bronchopulmonary dysplasia. In Bronchopulmonary dysplasia: Strategies for Total Patient Care. Ed. by C.H. Lund. 1989. P. 48-73.Abman S.H. Approach to the child with pulmonary hypertension and bronchopulmonary dys¬plasia. Advances in pulmonary hypertension. 2011. V. 10. N 2. P. 98—103.Abman S.H. Approach to the child with pulmonary hypertension and bronchopulmonary dysplasia // Advances in pulmonary hypertension. 2011. V. 10. № 2. P. 98-103.Abman S.H. Monitoring cardiovascular function in infants with chronic lung disease of pre¬maturity. Arch. Dis. Child. Fetal. Neonatol. Ed. 2002. P. 87: F15.Abman S.H. Monitoring cardiovascular function in infants with chronic lung disease of prematurity // Arch. Dis. Child. Fetal. Neonatol. Ed. 2002. P. 87: F15.Cerro M.J., Abman S., Diaz G. et al. A consensus approach to the classification of pediatric pul¬monary hypertensive vascular disease: Report from the PVRI Pediatric Taskforce, Panama 2011. Pulm Circ. 2011. V. 1. N 2. P. 286—298.Cerro M.J., Abman S., Diaz G. et al. A consensus approach to the classification of pediatric pulmonary hypertensive vascular disease: Report from the PVRI Pediatric Taskforce, Panama 2011 // Pulm Circ. 2011. V. 1. № 2. P. 286-298.Young T. & Mangum B. Neofax 2006. M.: Vereteya. 2006. 332 p.Янг Т., Мангум Б. Неофакс 2006. М.: Веретея. 2006. 332 с.Mourani P.M., Sontag M.K., Dunbar Ivy D. et al. Effects of Long-term Sildenafil Treatment for Pulmonary Hypertension in Infants with Chronic Lung Disease. J Pediatr. 2009. V. 154. N 3. P. 379—384.Mourani P.M., Sontag M.K., Dunbar Ivy D. et al. Effects of Long-term Sildenafil Treatment for Pulmonary Hypertension in Infants with Chronic Lung Disease // J Pediatr. 2009. V. 154. № 3. P. 379-384.Classification of clinical forms of bronchopulmonary diseases in children. M., Russian Respiratory Society, 2009.Классификация клинических форм бронхолегочных заболеваний у детей. М., Российское респираторное общество, 2009.Greenough A., Kavvadia K., Johnson A.H. et al. A new simple chest radiograph score to predict chronic lung disease in prematurely born infants. British J. Radiol. 1999. N 72. P. 530—533.Greenough A., Kavvadia K., Johnson A.H. et al. A new simple chest radiograph score to predict chronic lung disease in prematurely born infants // British J. Radiol. 1999. № 72. P. 530-533.Edwards D.K. Radiographic aspects of bronchopulmonary dysplasia. J. Pediatr. 1979. N 95. P. 823—829.Edwards D.K. Radiographic aspects of bronchopulmonary dysplasia // J. Pediatr. 1979. № 95. 823-829.Galie N., Hoeper M. & Humbert M. Guidelines for the diagnosis and treatment of pulmonary hy-pertension. European Heart Journal. 2009. V. 30. N 20. P. 2493—2537.Galie N., Hoeper M., Humbert M. Guidelines for the diagnosis and treatment of pulmonary hypertension // European Heart Journal. 2009. V. 30. № 20. P. 2493-2537.Barst R.J, McGoon M., Torbicki A. et al. Diagnosis and differential assessment of pulmonary arte-rial hypertension. JACC. 2004. N 12. 40S—47S.Barst R.J., McGoon M., Torbicki A. et al. Diagnosis and differential assessment of pulmonary arterial hypertension // JACC. 2004. № 12. 40S-47S.Hansen A.R., Barnes C.M., Folkman J. & McElrath T.F. Maternal preeclampsia predicts the de-velopment of bronchopulmonary dysplasia. J Pediatr. 2010. N 156. P. 532—536.Hansen A.R., Barnes C.M., Folkman J., McElrath T.F. Maternal preeclampsia predicts the development of bronchopulmonary dysplasia // J Pediatr. 2010. № 156. 532-536.