RUDN Journal of MedicineRUDN Journal of MedicineВестник Российского университета дружбы народов. Серия: Медицина2313-02452313-0261Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)13957ArticlesСтатьиResearch ArticleUse of alcohol in oculographic studies as an experimental model of abnormal statesИспользование алкоголя в окулографических исследованиях для формирования экспериментальной модели абнормального состоянияZakharchenkoD VЗахарченкоДмитрий Валерьевичdz-ihna@mail.ruMankaevaO VМанкаеваОльга Васильевнаm_olga1978@mail.ruTorshinD VТоршинДмитрий Владимировичvtorshin@mail.ruSveshnikovaE DСвешниковаЕлена Дмитриевнаgelucht@gmail.comDementienkoV VДементиенкоВалерий Васильевичinfo@neurocom.ruDorokhovV BДороховВладимир Борисовичvbdorokhov@mail.ruInstitute of higher nervous activity and neurophysiology of RASИнститут высшей нервной деятельности и нейрофизиологии РАНPeoples’ Friendship University of RussiaРоссийский университет дружбы народовMoscow state medical-dental University n. a. I. EvdokimovМосковский государственный медико-стоматологический университет им А.И. ЕвдокимоваRussian national research medical University n.a. N.I. PirogovРоссийский национальный исследовательский медицинский университет им. Н.И. ПироговаJSC “Neurocom”ЗАО «Нейроком»151220163NO3 (2016)№3 (2016)222702112016Copyright ©; 2016, Захарченко Д.В., Манкаева О.В., Торшин Д.В., Свешникова Е.Д., Дементиенко В.В., Дорохов В.Б.2016Захарченко Д.В., Манкаева О.В., Торшин Д.В., Свешникова Е.Д., Дементиенко В.В., Дорохов В.Б.http://creativecommons.org/licenses/by/4.0https://journals.rudn.ru/medicine/article/view/13957The paper describes formation of abnormal conditions with the use of alcohol in a laboratory experiment. The generally accepted experimental model are evaluated from the point of view of their suitability for oculographic studies of operator activity. Recommendations for the use of these methods in oculographic study are given.В статье рассматривается практика формирования абнормальных состояний с применением алкоголя в условиях лабораторного эксперимента. Общепринятые экспериментальные модели оцениваются с точки зрения их пригодности для окулографических исследований операторской деятельности. Формулируются рекомендации по использованию данных методов в окулографическом исследовании.oculographyoperator activityfunctional ststusoculomotor responsevisual perceptionокулографияоператорская деятельностьфункциональные состоянияокуломоторные реакциизрительное восприятие[Williamson A.M., Feyer A.-M., Mattick R.P. et al. Developing measures of fatigue using an alcohol comparison to validate the effects of fatigue on performance // Accident Analysis & Prevention. 2001. V. 33. № 3. P. 313-326.][Allen A.J., Meda S.A., Skudlarski P. et al. Effects of alcohol on performance on a distraction task during simulated driving // Alcohol Clin Exp Res. 2009. V. 33. № 4. P. 617-625.][Dougherty D.M., Marsh D.M., Moeller F.G. et al. Effects of moderate and high doses of alcohol on attention, impulsivity, discriminability, and response bias in immediate and delayed memory task performance // Alcoholism: Clinical and Experimental Research. 2000. V. 24. № 11. P. 1702-1711.][Post R.B., Lott L.A., Maddock R.J., Beede J.I. An effect of alcohol on the distribution of spatial attention // J Stud Alcohol. 1996. V. 57. № 3. P. 260-266.][Marple-Horvat D.E., Chattington M., Anglesea M. et al. Prevention of coordinated eye movements and steering impairs driving performance // Experimental brain research. 2005. V. 163. № 4. P. 411-420.][Weiler J.M., Bloomfield J.R., Woodworth G.G. et al. Effects of Fexofenadine, Diphenhydramine, and Alcohol on Driving PerformanceA Randomized, Placebo-Controlled Trial in the Iowa Driving Simulator. Annals of Internal Medicine. 2000. V. 132. № 5. P. 354-363.][Crowdy K.A., Marple-Horvat D.E. Alcohol affects eye movements essential for visually guided stepping // Alcoholism: Clinical and Experimental Research. 2004. V. 28. № 3. P. 402-407.][Ogden E., Moskowitz H. Effects of alcohol and other drugs on driver performance // Traffic injury prevention. 2004. V. 5. № 3. P. 185-198.][Zoethout R.W., Schoemaker R.C., Zuurman L. et al. Central nervous system effects of alcohol at a pseudo-steady-state concentration using alcohol clamping in healthy volunteers // British Journal of Clinical Pharmacology. 2009. V. 68. № 4. P. 524.][Versavel M., Zuhlsdorf M., Unger S. et al. Concentration-effect relationships of alcohol in a computerised psychometric test system // Arzneimittelforschung. 2005. V. 55. P. 289-295.][Abroms B.D., Gottlob L.R., Fillmore M.T. Alcohol effects on inhibitory control of attention: distinguishing between intentional and automatic mechanisms // Psychopharmacology. 2006. V. 188. № 3. P. 324-334.][Meda S.A., Calhoun V.D., Astur R.S. et al. Alcohol dose effects on brain circuits during simulated driving: an fMRI study // Human brain mapping. 2009. V. 30. № 4. P. 1257-1270.][Mills K.C., Spruill S.E., Walker J.M., Lamson M. A clinical trial demonstration of a web-based test for alcohol and drug effects // Journal of studies on alcohol and drugs. 2009. V. 70. № 2. P. 308.][Vakulin A., Baulk S.D., Catcheside P.G. et al. Effects of moderate sleep deprivation and low-dose alcohol on driving simulator performance and perception in young men // Sleep. 2007. V. 30. № 10. P. 1327.]