RUDN Journal of MedicineRUDN Journal of MedicineВестник Российского университета дружбы народов. Серия: Медицина2313-02452313-0261Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)13955ArticlesСтатьиResearch ArticleDistribution of the AGT T174M and AGTR1 A1166C polymorphic markers of cardiovascular diseases among populations of Algeria, Syria and Central RussiaРаспределение полиморфных маркеров сердечно-сосудистых заболеваний - T174M гена ангиотензина и А1166С гена рецептора 1 типа к ангиотензину в выборках из популяций Алжира, Сирии и Центральной РоссииAitAissaAАитАиссаАмирааit.mira90@hotmail.frAzovaM MАзоваМадина Мухамедовнаazova_mm@pfur.ruGiganiO OГиганиОльга Олеговнаgigani_oo@pfur.ruGiganiO BГиганиОльга Борисовнаgigani_ob@pfur.ruBlagonravovM LБлагонравовМихаил Львовичblagonravov_ml@pfur.ruPeoples’ Friendship University of RussiaРоссийский университет дружбы народов151220163NO3 (2016)№3 (2016)91402112016Copyright ©; 2016, АитАисса А., Азова М.М., Гигани О.О., Гигани О.Б., Благонравов М.Л.2016АитАисса А., Азова М.М., Гигани О.О., Гигани О.Б., Благонравов М.Л.http://creativecommons.org/licenses/by/4.0https://journals.rudn.ru/medicine/article/view/13955We investigated the distribution of the AGT T174M and AGTR1 A1166C polymorphisms, which predispose to cardiovascular diseases, among Algerians, Syrians and Russians from Central Russia. The genotypes were determined with the use ofallele-specific PCR. A significant difference between the studied samples was revealed in the T174M genotype distribution, whereas no significant difference was found in case of the A1166C polymorphism.Проанализирована частота полиморфизмов T174M гена AGT и А1166С гена AGTR1 , ассоциированных с сердечно-сосудистыми заболеваниями, среди популяций Алжира, Сирии и русских из центральной России. Определение полиморфизмов осуществлялось методом аллель-специфичной ПЦР. Выявлено достоверное различие между изучаемыми выборками в распределении генотипов по полиморфизму T174М, в то время как по полиморфизму А1166С значимых отличий обнаружено не было (p = 0,93).T174Mgene polymorphismT174MA1166Cpopulationcardiovascular diseasesгенный полиморфизмА1166Спопуляциясердечно-сосудистые заболевания1.Amrani A., Mesli Taleb Bendieb F., Baba Hamed M B. Relationship between Angiotensinogen gene T174M polymorphism and essential hypertension in a sample of Algerian population: case control study // J Med. 2014. V. 14. № 4. P. 168-173.2.Bayramoglu A., Kurt H., Gunes HV. et al. Angiotensin II Type 1 Receptor (AT1) Gene A1166C is Associated with the Risk of Hypertension // Genet Test Mol Biomarkers. 2015. V. 19. № 1. P. 7-14.3.de Denus S., Zakrzewski-Jakubiak M., Dubé MP. et al. Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan // Ann Pharmacother. 2008. V. 42. № 7. P. 925-932.4.Diez J., Laviades C., Orbe J. et al. The A1166C polymorphism of the AT1 receptor gene is associated with collagen type I synthesis and myocardial stiffness in hypertensives // J Hypertens. 2003. V. 21. № 11. P. 2085-2092.5.Frossard PM., Hill SH., Elshahat YI. et al. Associations of angiotensinogen gene mutations with hypertension and myocardial infarction in a gulf population // Clin Genet. 1998. V. 54. № 4. P. 285-293.6.URL: http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=4762.7.URL: http://www.who.int/mediacentre/factsheets/fs317/en.8.Jeunemaitre X., Soubrier F., Kotelevtsev Y.V. et al. Molecular basis of human hypertension: role of angiotensinogen // Cell. 1992. V. 71. P. 169-180.9.Li Y., Li X., Jia N. et al. Meta-analysis of the association between angiotensin II receptor, type 1 gene A1166C polymorphism and coronary artery disease in Chinese populations // J Renin Angiotensin Aldosterone Syst. 2013. V. 14. № 1. P. 82-90.10.Liu Y., Zhuoma C., Shan G. et al. A1166C polymorphism of the angiotensin II type 1 receptor gene and essential hypertension in Han, Tibetan and Yi populations // Hypertens Res. 2002. V. 25. № 4. P. 515-521.11.Pacurari M., Tchounwou PB. Role of MicroRNAs in Renin-Angiotensin-Aldosterone System-Mediated Cardiovascular Inflammation and Remodeling // Int J Inflam. 2015. V. 2015. P. 1-7.12.R Core Team. 2015. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL http://www.R-project.org.13.Spiridonova M.G., Stepanov V.A., Puzyrev V.P. et al. Association between Polymorphism T174M of the Angiotensinogen Gene and Coronary Atherosclerosis in the Tomsk Population // Molecular Biology. 2001. V. 35. № 1. P. 11-14.14.Van Thiel BS., van der Pluijm I., Te Riet L. et al. The renin-angiotensin system and its involvement in vascular disease // Eur J Pharmacol. 2015. V. 763. P. 3-14.