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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Ecology and Life Safety</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Ecology and Life Safety</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Экология и безопасность жизнедеятельности</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-2310</issn><issn publication-format="electronic">2408-8919</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">36239</article-id><article-id pub-id-type="doi">10.22363/2313-2310-2023-31-3-323-338</article-id><article-id pub-id-type="edn">SXEMXM</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Ecology</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Экология</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Study and analysis of the resistance of Enterococcus bacteria to antibiotics</article-title><trans-title-group xml:lang="ru"><trans-title>Изучение и анализ резистентности бактерий рода Enterococcus к антибиотикам</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7515-1207</contrib-id><contrib-id contrib-id-type="spin">2127-7799</contrib-id><name-alternatives><name xml:lang="en"><surname>Uskova</surname><given-names>Svetlana S.</given-names></name><name xml:lang="ru"><surname>Ускова</surname><given-names>Светлана Сергеевна</given-names></name></name-alternatives><bio xml:lang="en"><p>post-graduate student, Institute of the World</p></bio><bio xml:lang="ru"><p>аспирант, Институт Мирового океана</p></bio><email>uskova.ss@yandex.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6823-5971</contrib-id><contrib-id contrib-id-type="spin">1842-1670</contrib-id><name-alternatives><name xml:lang="en"><surname>Martynova</surname><given-names>Alina V.</given-names></name><name xml:lang="ru"><surname>Мартынова</surname><given-names>Алина Викторовна</given-names></name></name-alternatives><bio xml:lang="en"><p>Doctor of Medical Sciences, Professor of the Department of Biodiversity and Marine Bioresources, Institute of the World Ocean</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор кафедры биоразнообразия и морских биоресурсов, Институт Мирового океана</p></bio><email>clinmicro@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kim</surname><given-names>Aleksandra V.</given-names></name><name xml:lang="ru"><surname>Ким</surname><given-names>Александра Вячеславовна</given-names></name></name-alternatives><bio xml:lang="en">Ph.D. Biol. Sciences, Senior Lecturer, Dept. Biodiversity and Marine Bioresources, Institute of the World Ocean</bio><bio xml:lang="ru">кандидат биологических наук, старший преподаватель каф. биоразнообразия и морских биоресурсов, Институт Мирового океана</bio><email>kim-sandra@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Far Eastern Federal University</institution></aff><aff><institution xml:lang="ru">Дальневосточный федеральный университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-09-30" publication-format="electronic"><day>30</day><month>09</month><year>2023</year></pub-date><volume>31</volume><issue>3</issue><issue-title xml:lang="en">VOL 31, NO3 (2023)</issue-title><issue-title xml:lang="ru">ТОМ 31, №3 (2023)</issue-title><fpage>323</fpage><lpage>338</lpage><history><date date-type="received" iso-8601-date="2023-10-04"><day>04</day><month>10</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Uskova S.S., Martynova A.V., Kim A.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Ускова С.С., Мартынова А.В., Ким А.В.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Uskova S.S., Martynova A.V., Kim A.V.</copyright-holder><copyright-holder xml:lang="ru">Ускова С.С., Мартынова А.В., Ким А.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/ecology/article/view/36239">https://journals.rudn.ru/ecology/article/view/36239</self-uri><abstract xml:lang="en"><p style="text-align: justify;">Enterococci have acquired resistance to almost all classes of antibiotics. The purpose of this study was to study and analyze the resistance of Enterococcus bacteria to antibiotics isolated from Vladivostok water bodies. The antibiotic resistance of 70 strains of the genus Enterococcus to such antibiotics as tetracycline, streptomycin, erythromycin, ampicillin, levofloxacin, rifampicin, gentamicin, vancomycin was studied by disco diffusion. It turned out that in b. In the b. Zolotoy Rog, more than half of the isolated strains were resistant to streptomycin, erythromycin, and levofloxacin, and in the r. Vtoraya Rechka, more than 50 % of the strains were resistant to streptomycin and rifampicin. The isolated population of enterococcal strains was characterized by multiple resistance to two antibiotics (41 %) in the Second River and three or more antibiotics (45 %) in the Golden River. The most common was resistance to a combination of antibiotics such as streptomycin, rifampicin and erythromycin.</p></abstract><trans-abstract xml:lang="ru"><p style="text-align: justify;">Энтерококки приобрели резистентность почти ко всем классам антибиотиков. Цель данного исследования - изучение и анализ резистентности бактерий рода Enterococcus к антибиотикам, выделенных из водных объектов г. Владивостока. Была изучена атибиотикорезистентность 70 штаммов рода Enterococcus диско-диффузным методом к таким антибиотикам, как тетрациклин, стрептомицин, эритромицин, ампициллин, левофлоксацин, рифампицин, гентамицин, ванкомицин. Было выявлено, что в б. Золотой Рог более половины выделенных штаммов обладали резистентностью к стрептомицину, эритромицину и левофлоксацину, а в р. Вторая Речка более 50 % штаммов к стрептомицину и рифампицину. Выделенная популяция штаммов энтерококков характеризовалась мультирезистентностью к двум антибиотикам (41 %) в р. Вторая Речка и трем или более антибиотикам (45 %) в б. Золотой. Чаще всего встречалась резистентность к сочетанию таких антибиотиков, как стрептомицин, рифампицин и эритромицин.</p></trans-abstract><kwd-group xml:lang="en"><kwd>enterococci</kwd><kwd>resistance properties</kwd><kwd>antibiotics</kwd><kwd>bacteria</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>энтероккоки</kwd><kwd>свойства резистентности</kwd><kwd>антибиотики</kwd><kwd>бактерии</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Krasnaya YuV. Significance of bacteria of genus Enterococcus in human activity. Modern problems of science and education. 2014;6:1169–1178. (In Russ.) Available from: https://science-education.ru/ru/article/view?id=16620 https://science-education.ru/ru/article/view?id=16620 (accessed: 17.07.2023).</mixed-citation><mixed-citation xml:lang="ru">Красная Ю.В., Нестеров А.С., Потатуркина-Нестерова Н.И. Значение бактерий рода Enterococcus в жизнедеятельности человека // Современные проблемы науки и образования. 2014. № 6. С. 1169-1178. URL: https://science-education.ru/ru/article/view?id=16620 (дата обращения: 17.07.2023).</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Veljovic K, Popvic N, Vidojevic M, Tolinacki M, Mihailovic S, Jovcic B, Kojic M. Environmental waters as a source of antibiotic-resistant Enterococcus species in Belgrade, Serbia. Environmental Monitoring and Assessment. 2015;187(9):1–15. http://doi.org/10.1007/s10661-015-4814-x</mixed-citation><mixed-citation xml:lang="ru">Veljovic K. et al. Environmental waters as a source of antibiotic-resistant Enterococcus species in Belgrade, Serbia // Environmental Monitoring and Assessment. 2015. Vol. 187, № 9. P. 1-15. http://doi.org/10.1007/s10661-015-4814-x</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Hammerum AM. Enterococci of animal origin and their significance for public health. Clinical Microbiology and Infection. 2012;18(7):619–625. http://doi.org/10.1111/j.1469-0691.2012.03829.x</mixed-citation><mixed-citation xml:lang="ru">Hammerum AM. Enterococci of animal origin and their significance for public health // Clinical Microbiology and Infection. 2012. Vol. 18, № 7. P. 619-625. http://doi.org/10.1111/j.1469-0691.2012.03829.x</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Pashvina DV. Peculiarities of virulence potential of clinical isolates of enterococci gained from amimals: thesis for Candidate of biological science. Orenburg, 2015. 116 p. (In Russ.) Available from: https://www.dissercat.com/content/kharakteristika-virulentnogo-potentsiala-klinicheskikh-izolyatov-enterokokkov-vydelennykh (accessed: 17.07.2023).</mixed-citation><mixed-citation xml:lang="ru">Пашвина Д. В. Характеристика вирулентного потенциала клинических изолятов энтерококков, выделенных от животных: дис. … канд. биол. наук. Оренбург, 2015. 116 с. URL: https://www.dissercat.com/content/kharakteristika-virulentnogo-potentsiala-klinicheskikh-izolyatov-enterokokkov-vydelennykh (дата обращения: 17.07.2023).</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">Cesare Di A. The marine environment as a reservoir of enterococci carrying resistance and virulence genes strongly associated with clinical strains. Environmental Microbiology Reports. 2014;6(2):184–190. Available: http://doi.org/10.1111/1758-2229.12125</mixed-citation><mixed-citation xml:lang="ru">Cesare Di A. et al. The marine environment as a reservoir of enterococci carrying resistance and virulence genes strongly associated with clinical strains // Environmental Microbiology Reports. 2014. Vol. 6, № 2. P. 184-190. http://doi.org/10.1111/1758-2229.12125</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">Pasquaroli S. et al. Erythromycin- and copper-resistant Enterococcus hirae from marine sediment and co-transfer of erm(B) and tcrB to human Enterococcus faecalis. Diagnostic Microbiology and Infectious Disease. 2014;80(1):26–28. http://doi.org/10.1016/j.diagmicrobio.2014.06.002</mixed-citation><mixed-citation xml:lang="ru">Pasquaroli S. et al. Erythromycin- and copper-resistant Enterococcus hirae from marine sediment and co-transfer of erm(B) and tcrB to human Enterococcus faecalis // Diagnostic Microbiology and Infectious Disease. 2014. Vol. 80, № 1. P. 26-28. http://doi.org/10.1016/j.diagmicrobio.2014.06.002</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Weiner-Lastinger LM. et al. Antimicrobial-resistant pathogens associated with adult healthcare-associated infections: summary of data reported to the National Healthcare Safety Network, 2015–2017. Infection Control Hospital Epidemiology. 2020;41:1–18. http://doi.org/10.1017/ice.2019.296</mixed-citation><mixed-citation xml:lang="ru">Weiner-Lastinger L.M. et al. Antimicrobial-resistant pathogens associated with adult healthcare-associated infections: summary of data reported to the National Healthcare Safety Network, 2015-2017 // Infection Control Hospital Epidemiology. 2020. Vol. 41.P. 1-18. http://doi.org/10.1017/ice.2019.296</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">Korajkic A, McMinn BR, Staley ZR, Ahmed W, Harwood VJ. Antibiotic-resistant Enterococcus species in marine habitats: A review. Current Opinion in Environmental Science &amp; Health. 2016;16:92–100. http://doi.org/10.1016/j.coesh.2020.07.003</mixed-citation><mixed-citation xml:lang="ru">Korajkic A. et al. Antibiotic-resistant Enterococcus species in marine habitats: A review // Current Opinion in Environmental Science &amp; Health. 2016. Vol. 16. P. 92-100. http://doi.org/10.1016/j.coesh.2020.07.003</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">Hicks LA, Bartoces MG, Roberts RM, Suda KJ, Hunkler RJ, Taylor TH, Schrag SJ. US outpatient antibiotic prescribing variation according to geography, patient population, and provider specialty in 2011. Clinical Infectious Diseases. 2015;60:1308–1316. http://doi.org/10.1093/cid/civ076</mixed-citation><mixed-citation xml:lang="ru">Hicks L.A. et al. US outpatient antibiotic prescribing variation according to geography, patient population, and provider specialty in 2011 // Clinical Infectious Diseases. 2015. Vol. 60. P. 1308-1316. http://doi.org/10.1093/cid/civ076</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">Fleming-Dutra KE. et al. Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010-2011. Journal of American Medical Association. 2016;315:1864–1873. http://doi.org/10.1001/jama.2016.4151</mixed-citation><mixed-citation xml:lang="ru">Fleming-Dutra KE. et al. Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010-2011 // Journal of American Medical Association. 2016. Vol. 315. P. 1864-1873 http://doi.org/10.1001/jama.2016.4151</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">Zemlyanko OM. Mechanisms of multiresistance of bacteria to antibiotics. Ecological genetics. 2018;16(3):4–17. (In Russ.) URL: https://cyberleninka.ru/article/n/mehanizmy-mnozhestvennoy-ustoychivosti-bakteriy-k-antibiotikam (accessed: 12.07.2023).</mixed-citation><mixed-citation xml:lang="ru">Землянко О.М., Рогоза Т.М., Журавлева Г.А. Механизмы множественной устойчивости бактерий к антибиотикам // Экологическая генетика. 2018. Т. 16. № 3. С. 4-17. URL: https://cyberleninka.ru/article/n/mehanizmy-mnozhestvennoy-ustoychivosti-bakteriy-k-antibiotikam (дата обращения: 12.07.2023).</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">Egorov NS. Basics of study of antibiotics./textbook 6 ed. rewised and added. Moscow: Moscow State University, Science. 2004. 580 p. (In Russ.) Available from: http://www.vixri.ru/d3/Egorov%20%20_Osnovy%20uchenija%20ob%20antibiotikax,%20izd.6,%202004,%20528s.pdf (accessed: 16.07.2023).</mixed-citation><mixed-citation xml:lang="ru">Егоров Н.С. Основы учения об антибиотиках: учебник. 6-е изд., перераб. и доп. М.: Изд-во МГУ, Наука, 2004. 580 с. URL: http://www.vixri.ru/d3/Egorov%20%20_Osnovy%20uchenija%20ob%20antibiotikax,%20izd.6,%202004,%20528s.pdf (дата обращения: 16.07.2023).</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">Acar JF, Buu-Hoi AY. Resistance patterns of important Gram-positive pathogens. Journal of Antimicrobial Chemotherapy. 1988;21:41–47. http://doi.org/10.1093/jac/21.suppl_c.41</mixed-citation><mixed-citation xml:lang="ru">Acar J.F., Buu-Hoi A.Y. Resistance patterns of important Gram-positive pathogens // Journal of Antimicrobial Chemotherapy. 1988. Vol. 21. P. 41-47. DOI: 10.1093/jac/21.suppl_c.41</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">Nakayama J, Ruhfel RE, Dunny GM, Isogal A, Suzuki A. The prgQ gene of the Enterococcus faecalis tetracycline resistance plasmid pCF10 encodesa peptide inhibitor, iCF10. Journal of Bacteriology. 1994;176(23):7405–7408. http://doi.org/10.1128/jb.176.23.7405-7408.1994</mixed-citation><mixed-citation xml:lang="ru">Nakayama J. et al. The prgQ gene of the Enterococcus faecalis tetracycline resistance plasmid pCF10 encodes a peptide inhibitor, iCF10 // Journal of Bacteriology. 1994. Vol. 176, № 23. P. 7405-7408. http://doi.org/10.1128/jb.176.23.7405-7408.1994</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">Huys G, D’Haene K, Collard J, Swings J. Prevalence and Molecular Characterization of Tetracycline Resistance in Enterococcus Isolates from Food. Applied and Environmental Microbiology. 2004;70(4):1555–1562. http://doi.org/10.1128/AEM.70.3.1555-1562.2004</mixed-citation><mixed-citation xml:lang="ru">Huys G. Prevalence and Molecular Characterization of Tetracycline Resistance in Enterococcus Isolates from Food // Applied and Environmental Microbiology. 2004. Vol. 70. P. 1555-1562. http://doi.org/10.1128/AEM.70.3.1555-1562.2004</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">Chow JW. Aminoglycoside Resistance in Enterococci. Clinical Infectious Diseases. 2000;31(2):586–589. http://doi.org/10.1086/313949</mixed-citation><mixed-citation xml:lang="ru">Chow J.W. Aminoglycoside Resistance in Enterococci // Clinical Infectious Diseases. 2000. Vol. 31, № 2. P. 586-589. http://doi.org/10.1086/313949</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">Leclercq R. et al. Resistance of enterococci to aminoglycosides and glycopeptides. Clinical Infectious Diseases. 1992;15(3):495–501. http://doi.org/10.1093/clind/15.3.495</mixed-citation><mixed-citation xml:lang="ru">Leclercq R. et al. Resistance of enterococci to aminoglycosides and glycopeptides // Clinical Infectious Diseases. 1992. Vol. 15, № 3. P. 495-501. http://doi.org/10.1093/clind/15.3.495</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">Zou LK. et al. Erythromycin resistance and virulence genes in Enterococcus faecalis from swine in China. New Microbiologica. 2011;34(1):73–80. Available from: https://www.newmicrobiologica.org/PUB/allegati_pdf/2011/1/73.pdf (accessed 17.07.2023).</mixed-citation><mixed-citation xml:lang="ru">Zou L.K. Erythromycin resistance and virulence genes in Enterococcus faecalis from swine in China // New Microbiologica. 2011. Vol. 34, № 1. P. 73-80. URL: https://www.newmicrobiologica.org/PUB/allegati_pdf/2011/1/73.pdf (дата обращения: 17.07.2023).</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">Rafailidis PI, Ioannidou EN, Falagas ME. Ampicillin/Sulbactam in Severe Bacterial Infections. Review Article. 2007;67(13):1829–1849. http://doi.org/10.2165/00003495-200767130-00003</mixed-citation><mixed-citation xml:lang="ru">Rafailidis P.I. Ampicillin/Sulbactam in Severe Bacterial Infections // Review Article. 2007. Vol. 67, № 13. P. 1829-1849. http://doi.org/10.2165/00003495-200767130-00003</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">Rice LB. Beta-lactam antibiotics and gastrointestinal colonization with vancomycin-resistant enterococci. The Journal of Infectious Diseases. 2005;24(12):804-814. http://doi.org/10.1007/s10096-005-0057-z</mixed-citation><mixed-citation xml:lang="ru">Rice L.B. Beta-lactam antibiotics and gastrointestinal colonization with vancomycin-resistant enterococci // The Journal of Infectious Diseases. 2005. Vol. 24, № 12. P. 804-814. http://doi.org/10.1007/s10096-005-0057-z</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">Marshall SH, Donskey CJ, Hutton-Thomas R, Salata RA, Rice LB. Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis. Antimicrobial Agents and Chemotherapy. 2002;46(10):3334–3336. http://doi.org/10.1128/AAC.46.10.3334-3336.2002</mixed-citation><mixed-citation xml:lang="ru">Marshall S.H. Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis // Antimicrobial Agents and Chemotherapy. 2002. Vol. 46, № 10. P. 3334-3336. http://doi.org/10.1128/AAC.46.10.3334-3336.2002</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">Oyamada Y, Ito H, Fujimoto K, Asada R. et al. Combination of known and unknown mechanisms confers high-level resistance to fluoroquinolones in Enterococcus faecium. Journal of Medical Microbiology. 2006;55(6):729–736. http://doi.org/10.1099/jmm.0.46303-0</mixed-citation><mixed-citation xml:lang="ru">Oyamada Y. et al. Combination of known and unknown mechanisms confers high-level resistance to fluoroquinolones in Enterococcus faecium // Journal of Medical Microbiology. 2006. Vol. 55, № 6. P. 729-736. http://doi.org/10.1099/jmm.0.46303-0</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">Sedova MK. Development of content and methods of quality control of hard drug substance of levofloxacine: thesis of candidate pharmacological science. Moscow; 2016. 167 p. (In Russ.) Available from: http://www.dslib.net/farmakognozia/razrabotka-sostava-i-metodov-kontrolja-kachestva-tverdoj-lekarstvennoj-formy.html (accessed: 17.07.2023).</mixed-citation><mixed-citation xml:lang="ru">Седова М.К. Разработка состава и методов контроля качества твердой лекарственной формы левофлоксацина: дис. … канд. фарм. наук. М., 2016. 167 с. URL: http://www.dslib.net/farmakognozia/razrabotka-sostava-i-metodov-kontrolja-kachestva-tverdoj-lekarstvennoj-formy.html (дата обращения: 17.07.2023).</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">Yasufuku T. et al. Mechanisms of and Risk Factors for Fluoroquinolone Resistance in Clinical Enterococcus faecalis Isolates from Patients with Urinary Tract Infections. Journal of Clinical Microbiology. 2011;49(11):3912–3916. http://doi.org/10.1128/JCM.05549-11</mixed-citation><mixed-citation xml:lang="ru">Yasufuku T. Mechanisms of and Risk Factors for Fluoroquinolone Resistance in Clinical Enterococcus faecalis Isolates from Patients with Urinary Tract Infections // J. Clin. Microbiol. 2011. Vol. 49, № 11. P. 3912-3916. http://doi.org/10.1128/JCM.05549-11</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">Rattanaumpawan P, Tolomeo P, Bilker WB, Fishman NO, Lautenbach E. Risk factors for fluoroquinolone resistance in Enterococcus urinary tract infections in hospitalized patients. Epidemiology and Infections. 2011;139:955–961. http://doi.org/10.1017/S095026881000186X</mixed-citation><mixed-citation xml:lang="ru">Rattanaumpawan P. Risk factors for fluoroquinolone resistance in Enterococcus urinary tract infections in hospitalized patients // Epidemiology and Infections 2011. Vol. 139. P. 955-961. http://doi.org/10.1017/S095026881000186X</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">Enne VI, Delsol AA, Roe JM, Bennett PM. Rifampicin resistance and its fitness cost in Enterococcus faecium. Journal of Antimicrobial Chemotherapy. 2004;53(2):203–207. http://doi.org/10.1093/jac/dkh044</mixed-citation><mixed-citation xml:lang="ru">Enne V.I. Rifampicin resistance and its fitness cost in Enterococcus faecium // Journal of Antimicrobial Chemotherapy. 2004. Vol. 53, № 2. P. 203-207. http://doi.org/10.1093/jac/dkh044</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">Aslangul E, Massias L, Meulemans A, Chau F, Andremont A, Courvalin P, Fantin B, Ruimy R. Acquired Gentamicin Resistance by Permeability Impairment in Enterococcus faecalis. Antimicrobial Agents and Chemotherapy. 2006;50(11):3615–3621. http://doi.org/10.1128/AAC.00390-06</mixed-citation><mixed-citation xml:lang="ru">Aslangul E. Acquired Gentamicin Resistance by Permeability Impairment in Enterococcus faecalis // Antimicrobial Agents and Chemotherapy. 2006. Vol. 50, № 11. P. 3615-3621. http://doi.org/10.1128/AAC.00390-06</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">Jolivet S. et al. First nosocomial outbreak of vanA-type vancomycin-resistant Enterococcus raffinosus in France. Journal of Hospital Infection. 2016;94 (4):346–350. http://doi.org/10.1016/j.jhin.2016.09.004</mixed-citation><mixed-citation xml:lang="ru">Jolivet S. First nosocomial outbreak of vanA-type vancomycin-resistant Enterococcus raffinosus in France // Journal of Hospital Infection. 2016. Vol. 94, № 4. P 346-350. http://doi.org/10.1016/j.jhin.2016.09.004</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">Cetinkaya Y, Fallk P, Mayhall C. Vancomycin-Resistant Enterococci. Clinical Microbiology Review. 2000;13(4):686–707. http://doi.org/10.1128/CMR.13.4.686</mixed-citation><mixed-citation xml:lang="ru">Cetinkaya Y. Vancomycin-Resistant Enterococci // Clin. Microbiol. Rev. 2000. Vol. 13, № 4. Р. 686-707. http://doi.org/10.1128/CMR.13.4.686</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">Hijazi NM, Elmanama AA, Al-Hindi A. Vancomycin-Resistant Enterococci in Fecal Samples from Hospitalized Patients and Non-Hospitalized Individuals in Gaza City. Journal of Public Health. 2009;17(19):243–249. http://doi.org/10.1007/s10389-008-0242-5</mixed-citation><mixed-citation xml:lang="ru">Hijazi N.M. Vancomycin-Resistant Enterococci in Fecal Samples from Hospitalized Patients and Non-Hospitalized Individuals in Gaza City // Journal of Public Health. 2009. Vol. 17, № 19. Р. 243-249. http://doi.org/10.1007/s10389-008-0242-5</mixed-citation></citation-alternatives></ref></ref-list></back></article>
