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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Contemporary Mathematics. Fundamental Directions</journal-id><journal-title-group><journal-title xml:lang="en">Contemporary Mathematics. Fundamental Directions</journal-title><trans-title-group xml:lang="ru"><trans-title>Современная математика. Фундаментальные направления</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2413-3639</issn><issn publication-format="electronic">2949-0618</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">33500</article-id><article-id pub-id-type="doi">10.22363/2413-3639-2022-68-4-716-731</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Existence of solution of a free boundary problem for reaction-diffusion systems</article-title><trans-title-group xml:lang="ru"><trans-title>Существование решения задачи со свободной границей для систем «реакция-диффузия»</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Younes</surname><given-names>G. A.</given-names></name><name xml:lang="ru"><surname>Юнес</surname><given-names>Г. А.</given-names></name></name-alternatives><email>volpert@math.univ-lyon1.fr</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>El Khatib</surname><given-names>N.</given-names></name><name xml:lang="ru"><surname>Эль Хатиб</surname><given-names>Н.</given-names></name></name-alternatives><email>volpert@math.univ-lyon1.fr</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Volpert</surname><given-names>V. A.</given-names></name><name xml:lang="ru"><surname>Вольперт</surname><given-names>В. А.</given-names></name></name-alternatives><email>volpert@math.univ-lyon1.fr</email><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff id="aff1"><institution>Institut Camille Jordan</institution></aff><aff id="aff2"><institution>University Lyon 1</institution></aff><aff id="aff3"><institution>Lebanese American University</institution></aff><aff-alternatives id="aff4"><aff><institution xml:lang="en">Peoples’ Friendship University of Russia (RUDN University)</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2022</year></pub-date><volume>68</volume><issue>4</issue><issue-title xml:lang="en">VOL 68, NO4 (2022)</issue-title><issue-title xml:lang="ru">ТОМ 68, №4 (2022)</issue-title><fpage>716</fpage><lpage>731</lpage><history><date date-type="received" iso-8601-date="2023-02-06"><day>06</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Younes G.A., El Khatib N., Volpert V.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Юнес Г.А., Эль Хатиб Н., Вольперт В.А.</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Younes G.A., El Khatib N., Volpert V.A.</copyright-holder><copyright-holder xml:lang="ru">Юнес Г.А., Эль Хатиб Н., Вольперт В.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rudn.ru/CMFD/article/view/33500">https://journals.rudn.ru/CMFD/article/view/33500</self-uri><abstract xml:lang="en"><p style="text-align: justify;">In this paper, we prove the existence of solution of a novel free boundary problem for reaction-diffusion systems describing growth of biological tissues due to cell influx and proliferation. For this aim, we transform it into a problem with fixed boundary, through a change of variables. The new problem thus obtained has space and time dependent coeffcients with nonlinear terms. We then prove the existence of solution for the corresponding linear problem, and deduce the existence of solution for the nonlinear problem using the xed point theorem. Finally, we return to the problem with free boundary to conclude the existence of its solution.</p></abstract><trans-abstract xml:lang="ru"><p style="text-align: justify;">В работе доказывается существование решения новой задачи со свободной границей для систем типа «реакция-диффузия», описывающих рост биологических тканей вследствие притока клеток и пролиферации. Для этого задача сводится к задаче с закрепленной границей через замену переменных. Полученная задача имеет зависящие от времени и положения в пространстве коэффициенты с нелинейными слагаемыми. Затем мы доказываем существование решения для соответствующей линейной задачи и с помощью теоремы о неподвижной точке получаем существование решения нелинейной задачи. Наконец, мы возвращаемся к задаче со свободной границей и делаем вывод о существовании ее решения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>free boundary problem</kwd><kwd>reaction-diffusion system</kwd><kwd>growth of biological tissues</kwd><kwd>existence of solution</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>задача со свободной границей</kwd><kwd>система реакция-диффузия</kwd><kwd>рост биологических тканей</kwd><kwd>существование решения</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Bessonov N., Morozova N., Volpert V. Modeling of branching patterns in plants// Bull. Math. Biol. - 2008. - 70. - C. 868-893.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Fok P.-W. 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