Possible protective effect of enap in remodeling the extracellular space along heartaorta-femoral artery axis in different types of stress

At present there is no sufficient experimental data about adrenergic as well as parasympathetic effects on structural remodeling of myocardium and in the walls of large blood vessels. In the clinical research organoprotective effect of ACE inhibitor was widely discussed, the ACE inhibitor being connected with the suppression of the activity of renin-angiotensin-aldosterone system and the sympathetic nervous system. This notwithstanding, there are no well-outlined information about regression of the earliest evidence for remodeling of heart and blood vessels on extracellular level against the background of antihypertensive therapy. To determine the relation between remodeling of myocardium and blood vessels in different variants of accompanying vegetative stress we have compared the morphometrical data in rats of Vistar line under the influence of chronic adrenergic and cholinergic stress with the effect of medicine from ACE inhibitor group - Enap. The results showed that the remodeling of left ventricular myocardium, aorta and femoral artery took place under the conditions of all variants of vegetative provision of chronic stress being compared with the control group. Protective effect of ACE inhibitors was not observed in aorta and femoral artery under different models of chronic stress; moreover, in cases of chronic stress Enap administration increased remodeling of extracellular space of femoral artery. In the left ventricular myocardium, the protective effect of Enap was observed on remodeling of extracellular space only in case of chronic adrenergic stress.

remodeling, heart, blood vess