Proteins and microRNAs involved in papillomavirus infection


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Abstract

The review is devoted to the analysis of proteins, protein complexes and microRNAs involved in papillomavirus infection. The papilloma viruses belong to the family of DNA-containing papovaviruses (Papovaviridae) and infect the basal layers of the epithelium. Human papillomaviruses (HPV) have an oncogenic potential, which varies significantly. The ring genome HPV encodes 6 early proteins and 2 later proteins (envelope proteins), and uses the host cell proteins for its own replication. For infection the membrane proteins that bind to the host cell membrane are especially important. In this paper we analyzed the arrays of literature data on proteins and microRNAs involved in binding, internalization, transport of HPV virions, and virus multiplication. The analysis of literature data was carried out using the program PathwayStudio9 ® and the database ResNet13 ® of Elsivier (USA), as well as online services. Total was revealed 69 infection-related proteins and protein complexes and 3 microRNAs (72 in total). As a result of the subsequent detailed analysis of the literature, 17 proteins and microRNAs involved in the following processes were selected: penetration of virus particles into the cell (7), transport of the virus in the cytoplasm of the host cell (5), transfer of the virus DNA into the core of the host cell (1) and regulation of gene transcription HPV (4). These proteins and microRNAs are potential targets for drugs that can prevent and suppress HPV infection.

About the authors

E A Klimov

Lomonosov Moscow State University; University Diagnostic Laboratory, LLC; Center of Experimental Embryology and Reproductive Biotechnologies

Author for correspondence.
Email: klimov@mail.bio.msu.ru

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V V Sobolev

University Diagnostic Laboratory, LLC; I.I. Mechnikov Research Institute for Vaccines and Sera; Centre of Theoretical Problems of Physico-Chemical Pharmacology

Email: klimov@mail.bio.msu.ru

A M Solov’ev

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Email: klimov@mail.bio.msu.ru

Yu N Perlamutrov

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Email: klimov@mail.bio.msu.ru

I M Korsunskaya

Centre of Theoretical Problems of Physico-Chemical Pharmacology

Email: klimov@mail.bio.msu.ru

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Copyright (c) 2018 Klimov E.A., Sobolev V.V., Solov’ev A.M., Perlamutrov Y.N., Korsunskaya I.M.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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