No 4 (2012)

The possible mechanisms of the space weather influence on biological systems are discussed. Nonlinear processes of space weather influence to bio-systems are described. Based on recent theoretical models of the dynamics of the old Sun discusses cosmogeophysical influence factors on the adaptation processes and the formation of life on Earth.

Microbial capsular polysaccharides for many years provided a highly practical public health vaccines for preventing meningococcal, pneumococcal and Haemophilus influenza infection, and typhoid fever. Their application in the form of conjugates with protein carriers eliminate the gap in protection against these infections in children under one year. Extremely promising turned out offered us a new generation of vaccines, which have synthetic peptides conjugated to a meningococcal polysaccharide. Thus, new approaches to the solution of the problem of meningococcal disease vaccination serogroup B were open. In recent years, Russian researchers first suggested to use IgA1 protease (one of the major virulence factors of microbes and almost identical for mentioned below infections) for prevention of such diseases as meningococcal of all serogroups, pneumococcus and hemophilia infections. Patented processes for producing of the vaccine define domestic priority of its production and use.

Aim: to study the clinical semiology and vegetative dysfunction in young patients with various connective tissue dysplasia of heart (CTDH). Authentic differences in frequency of various complaints occurrence and features of vegetative dysfunction syndrome are established.

The work purpose — to define at patients with an arterial hypertension with a dyslipidemia extent of influence simvastatin on antiaggregatory control from vessels over erythrocytes, platelets and leukocytes. The arterial hypertension registered at patients with a dyslipidemia the strengthened aggregation of erythrocytes, platelets and neutrophils develops against decrease in control over it from the vascular wall, arising in many respects at the expense of violations in a lipidic exchange, activation of oxidation of lipids of plasma and weakening of generation of oxide of nitrogen and education prostacyclin. As a result of 104 week applications simvastatin at patients with an arterial hypertension with a dyslipidemia normalization of lipidic structure, processes of lipid peroxidation in plasma and blood cells and antiaggregatory ability of a vascular wall is reached.

Distribution analysis of alleles and genotypes of polymorphic markers C-262T catalaza gene in 90 patients with chronic obstructive pulmonary disease (COPD) in connection with presence and character of attendant cardiovascular pathology was made. Detection of polymorphic gene locus was made by polymerase chain reaction. Significant differences in genotypes frequency in patients with COPD and ischemic heart disease (IHD) and without it were discovered. Sstatistically significant increase of genotype CC frequency (relation of possibilities 5,13 p = 0,01) in COPD patients with IHD showed the increased risk of such pathology in CC genotype carriers. Among COPD patients with genotype CC higher indicators of malonate dialdehyde and lower catalaza level in blood serum were detected.

This article is devoted to the experience and the results of using artificial movement correction with programmed muscle electrostimulation in rehabilitation of patients after total knee arthroplasty by mini-invasive midvastus approach. Obtained data suggest that this method could be recommended in early post-operative rehabilitation of patients and provides significant improvement of operated knee-joint and extremity function by decrease of limping, motor function and pacing pattern recovery.

Possibility of spontaneous concretion discharge from ureter in many ways depends on efficiency of administered conservative therapy. According to the studies of several authors, confirming the presence of a1-adrenoceptors in the ureter wall, in our study we used a1-blocker tamsulosin. The probability of spontaneous concretion discharge from ureter using low intensive laser therapy and Tamsulosin increases in 3 times. It was showed that combination of low intensive laser therapy and Tamsulosin resulted to spontaneous discharge of the larger concrements comparing with traditional therapy and may be recommended for clinical practice.

In work three new methods of hernioplasty of the inguinal hernias, combining autodermoplasty with autoplasty are offered. In 163 (34,5%) cases preperitonealautodermoplasty in combination with autoplasty of anterior wall of the inguinal canal was applied. Long term postoperative observation (catamnesis of 11 years) revealed 6 (3,7%) relapses. Among 184 (37,8%) hernias with inguinal interspace of oval or fissured form, where consolidation of posterior wall of the inguinal canal was performed by Bassini method (North American variant) in combination with autodermoplasty, and in 140 (28,7%) patients with inguinal interspace of the triangular form of 5 cm and more in height, where the autoplasty with relaxing incision of rectus sheath in a combination with autodermoplasty was carried out, relapses were not diagnosed (catamnesis of 5 years). The differentiated approach to hernioplasty depending on a degree of destruction of posterior wall of the inguinal canal is justified by results of treatment.

We studied correlation between the degree of malignancy, prognosis, survival of oncological patients, and the number of proliferating cells (Ki-67 index), the rate of cell proliferation, the continuance of the mitotic cycle (and the expression of Ag-OYAOR-proteins-В23/nucleofozimine S23/nukleoline) in 16 patients with adrenocortical carcinoma and in 20 cases of “small” lung cancer (up to 3 cm in diameter), whose tumors were removed and long-term results were evaluated. The comparative study of proliferative activity of cells in the two groups of patients with different survival period after tumor removal showed the heterogeneity of Ki-67 index, which determined the number of proliferating cells. In the first group of patients (with a good prognosis) Ki-67 index was high, and expression of Ag-OYAOR proteins was low. At the same time, in the second group of patients, whose prognosis was poor, Ki-67 index in the tumor was low, but the expression of Ag-OYAOR-protein was high. So, we can make a conclusion, that it is impossible to discuss the degree of malignancy of the tumor and the prognosis, based only on Ki-67 index. Ag-OYAOR-protein and Ki-67 index reflect different aspects of cell proliferation: the rate of cell proliferation (Ag-OYAOR expression) and the number of proliferating cells (Ki-67 index).

The article deals with the study of hospitalized disease incidence of upper respiratory tract and evaluation of activity of the ENT-department in multi-field hospital. Data analysis shows that the largest group of hospitalized patients are the patients with diseases of the nasal cavity and paranasal sinuses.