No 3 (2011)

Articles
50 letMEDITsINSKOMU FAKUL'TETU
Frolov V.A.
Abstract
RUDN Journal of Medicine. 2011;(3):7-7
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Аbout typical responses of the damaged heart
Frolov V.A., Bilibin D.P., Blagonravov M.L., Drozdova G.A., Chibisov S.M.
Abstract
On the basis of experimental research we described nine typical (nonspecific) responses of the damaged heart which are initially protective and adaptive but are able to have a pathogenetic character under some certain conditions. These typical responses are as follows: shortening of the effective refractory period of the myocardium, cardiomyocyte mitochondrion swelling, activation of lysosomal apparatus, initial intensification of lipolysis, hypertrophy of cardiac muscle, formation of collagen muffs around blood vessels due to intoxication, functional deafferentation of the heart, changes in the intensity of cardiomyocyte apoptosis, rearrangement of cardiac chronostructure. The represented results can be used as a basis to elaborate some new effective methods of prophilaxis and treatment of heart diseases caused by different etiological factors.
RUDN Journal of Medicine. 2011;(3):8-11
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Corrective effect of modified gas medium and temperature on functional status in animals after carotid glomectomy
Torshin V.I., Kalashnikova E.Y., Shevchenko L.V., Elfimov A.I.
Abstract
Carotid glomectomy is an adequate method for studying the functional role of peripheral chemoreceptors in the regulation of body functions. After glomectomy in animals the blood glucose level increases, respiratory rate decreases, oxygen consumption and carbon footprint signs of anaemia develops. The results suggest the possibility of physiological correction of the level of glycemia and gas exchange in animals during periodic action of hypoxia, hypo- or hyperthermia after glomectomy.
RUDN Journal of Medicine. 2011;(3):12-16
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The system of microcirculation: clinical and morphological aspects of investigation
Kozlov V.I.
Abstract
Modern data about microcirculation disorders are presented. The methodical base of carrying out clinical-morphological and functional researches of microcirculation is discussed. The individual typological features of microcirculation caused by active and passive mechanisms of modulation of a tissue blood flow are revealed. The characteristics of different forms of microcirculation disorders (hyperemic, spastic, spastic-atonic, stagnat and stasic forms) are given. Classification of microcirculation disorders, including four degree of insufficiency of tissue blood flow is offered.
RUDN Journal of Medicine. 2011;(3):17-20
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Effect of adenylate cyclases activator on the cytoskeleton reorganization in thrombin-induced endothelial barrier dysfunction
Alieva I.B., Eremina I.Z., Savrova O.B., Verin A.D.
Abstract
This work executed on a model of endothelial monolayer in vitro, is devoted to the study of mechanisms leading to endothelial barrier dysfunction. The dysfunction inductor, thrombin, acts on endothelial cells through a specific receptor, triggering cascades of intracellular reactions (including cytoskeletal reorganization) resulting to increased of endothelial permeability. Thrombin-receptor interaction leads to dissociation of heterotrimeric G-protein subunits (Gi, Gq and G12/13), each of which is potentially capable to handle one or more possible ways of dysfunction development. In the present study we analyzed the role of Gi protein in the occurrence of cytoskeletal disturbances that lead to barrier dysfunction. According to our results, it can be assumed that the activity of Gi protein does not directly affect on the endothelial barrier properties.
RUDN Journal of Medicine. 2011;(3):21-25
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Role of intercellular adhesion molecules in the development of the endometrial neoplasias
Shelokova E.E., Kovyazin V.A., Babichenko I.I.
Abstract
In article the processes of intercellular adhesion in unchanged proliferating endometrium, hyperplasia and adenocarcinoma are surveyed. Expression E-kadherin, β-katenin and claudin-1 at different stages of epithelial neoplastic transformation of endometrium by immunohistochemical method had been estimated. The role of key proteins Wnt-signaling pathway and Claudine-1 in the development of malignant transformation of glandular cells of endometrium was established.
RUDN Journal of Medicine. 2011;(3):26-30
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Possibilities of using of phytoestogens for the correction of vaginal flora
Rybas Y.A., Rodrigo Alberto Bustamante Valdebenito -., Kravtsov E.G., Tchernitchin Varlamov A.N., Dalin M.V.
Abstract
The article deals with the testing of phytoestrogens containing in plants endemic to Chile. This research confirms that phytoextract has the similar effect upon the target-tissues like estradiol. It was detected, that this substance inhibits the stimulating action of estradiol over the population of lactobacillus in vagina.
RUDN Journal of Medicine. 2011;(3):31-33
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Matricsins 2, 7 and 9 in breast tumors. determination of posibile connection with the concentration of HER-2/neu
Kuznetsova O.M., Berezov Т.Т., Chernov N.N., Nazarenko A.Y., Kryuk Y.V., Tereshkina I.V., Kushlinskii N.E.
Abstract
The comparative analysis of the quantity of matrix metalloproteinases (MMP) 2,7 and 9 in breast cancer is carried out; the concentration of sex hormones receptors and protein HER-2/neu are determined. Authentically high values MMP-2 and MMP-7 are found in a tumor tissue in contrast to the normal one. The elevated concentration of ММР-2 in a tumor is connected with receptor status (p < 0,05). The highest values of concentration ММР-7 and ММP- 9 are found at RE-, RP- and HER-2/neu + tumors, and also in the tumors with the size more than 4,0 cm.
RUDN Journal of Medicine. 2011;(3):34-38
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Concept-formats of the training system for the highest qualification specialists in the field of fudamental medicine
Luk'yanova E.A., Protsenko V.D.
Abstract
The concept-formats of the automated network resource for degree candidates and their supervisors is discussed. The system helps to design the experiment, collect and analyze data. It can be used for motivation of candidates during preparation of scientific thesis.
RUDN Journal of Medicine. 2011;(3):39-41
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Non-fixation method of abdominal wall hernia repair
Protasov A.V., Smirnova E.D.
Abstract
Authors has developed algorithm of surgical treatment of the abdominal wall hernias, based on using the modern non-fixation mesh. This algorithm includes different surgical approaches (open and endoscopic) for inguinal and ventral hernias using polypropylene and polylactic acid mesh.
RUDN Journal of Medicine. 2011;(3):42-45
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Informational modelling of extreme states of victims in emergency situations
Sokov S.L.
Abstract
In this thesis conceptual model of adaptation (kinesis) syndromes of traumatic stress situation was proposed including information models of acute (traumatic) and chronic (sports or professional) overloaded and acute (premorbid) and chronic (senile) hypokinesis adaptation syndromes, which allow to prognoses the stage of traumatic disease and acute hypokinesia at molecular, cellular, organic and organism levels.
RUDN Journal of Medicine. 2011;(3):46-49
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Dynamics of morphological changes in lung in case of acute cerebral trauma complicated by blood aspiration
Sundukov D.V., Golubev A.M., Alisievich V.I., Shaman P., Leliovskaya A.A., Bashirova A.R., Rinkman O.S.
Abstract
26 pieces of corpses' lungs died from acute cerebral trauma had been investigated by morphological methods. The purpose of the research work is to estimate the character and time of morphological signs, which characterize acute lung injury. It was obtained that the most early morphological changes in lung - injuries of bronchial mucosa membrane, circulation damages (microcirculation), atelectasis, distelectasis and acute emphysema. Lung edema and signs of systemic inflammation reaction occur during the first hours after the trauma and aspiration.
RUDN Journal of Medicine. 2011;(3):50-53
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Medical rehabilitation of elderly patients
Zhernov V.A., Zubarkina M.M.
Abstract
The article presents the use of hirudoreflexotherapy, acupuncture, magnitorexlexotherapy in medical rehabilitation of elderly patients. It is noticed that hirudoreflexotherapy it is the most effective method in patients with an arterial hypertension of 1 degree, magnitoreflexotherapy - in patients with an arterial hypertension of 2 degrees.
RUDN Journal of Medicine. 2011;(3):54-56
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Microalbuminuria in risk stratification of non-diabetic hypertesive patients
Villevalde S.V., Tuykhmenev E.A., Klimenko A.S., Pigareva Y.A., Kobalava Z.D.
Abstract
Microalbuminuria (MAU) and a reduction in glomerular filtration rate are independent predictors of cardiovascular morbidity and mortality. Aim was to assess the role of MAU in risk stratification of non-diabetic hypertensive patients. The subgroup of patients with MAU was much more likely to show the other signs of subclinical organ damage as compared to patients with left ventricular hypertrophy, carotid abnormalities or increased pulse wave velocity. Thus, MAU is the integral marker of subclinical organ damage.
RUDN Journal of Medicine. 2011;(3):57-61
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Influence of basal level of the general cholesterol on efficacy of antiviral therapy of the chronic hepatitis with peg-interferon-α 2B and ribavirin
Ogurtsov P.P., Mazurchik N.V., Polikarpova T.S., Khafisova O.O.
Abstract
Chronic hepatitis С - one of the most widespread bloodborne infections in the world, which represents an important problem as one of the frequent causes of disability of young patients and indications to liver transplantation. One of the less studied, but extremely actual problems is eventual influence of the lipid exchange disturbances on the results of combined antiviral therapy. Influence of hypercholesterinemia on chronic HCV-infection and results of antiviral therapy are not studied enough and have certain scientific and practical value. 144 adults (> 18 years) with HCV-infection, who have passed their first course of antiviral therapy with PegIFNα-2b and ribavirin were surveyed. Low degree of fibrosis (measured by elastography, Fibroscan) or its absence was revealed in 77 patients while 67 patients had the significant fibrosis. Basal level of general cholesterol significantly did not differ in both groups. The level of general cholesterol was significantly above in convalescents despite of liver fibrosis degree. Patients with low fibrosis had significantly high level of general cholesterol in case of sustained viral response (SVR). Contrary in group of patients with the significant fibrosis the similar relations did not detected. Therefore, the baseline hypercholesterinemia is positive, irrespective of fibrosis degree, predictor of SVR.
RUDN Journal of Medicine. 2011;(3):62-66
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Treatment of migraine in general practice
Kuznetsov V.I., Sturov N.V., Mansur T.I., Kobylyanu G.N., Maslova A.N.
Abstract
Migraine is a rather common disorder in general practice. The article discusses the problems of pathogenesis and diagnosis of migraine, including the severe forms of the disease and its' different masks. The paper contains the data on the current approach to curing acute attacks and preventive treatment of migraine in general practice.
RUDN Journal of Medicine. 2011;(3):67-71
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Prevalence of ischemic heart disease among males with tuberculosis
Koshechkin V.A., Ivanova Z.A., Shirmanov A.I., Arsentieva N.V.
Abstract
Three follow-up single-stage standardized examinations for revealing of ischemic heart disease (IHD) were conducted among males at the age 50-59 with tuberculosis in 1972, 1998, 2011 years. The results of studies are conformed that prevalence of IHD among males with tuberculosis is not changed during this period and remained on relatively high level from 21.0-31.9%. Practically every 5th male with tuberculosis has clinical signs of IHD that could be considered as a support of necessity of joint simultaneous treatment of tuberculosis and IHD.
RUDN Journal of Medicine. 2011;(3):72-74
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Intraosseus method of treatment of painful distal symmetric diabetic polyneuropathy
Sokov E.L., Kornilova L.E., Arsyukhin N.A.
Abstract
We present the results of pilot study of the efficacy of intraosseous blockades in the treatment of painful distal symmetric diabetic polyneuropathy in 20 patients. High efficacy of intraosseous blockades was demonstrated.
RUDN Journal of Medicine. 2011;(3):75-78
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Variant of auto-allopsychic depersonalization in patients with latent schizophrenia
Suleymanov R.A., Artem'ieva M.S., Danilin I.E.
Abstract
The article deals with the results of psychological and psychiatric analysis of age regression in patients with latent schizophrenia along with depersonalization, infantilism and social phobia. Clinical and social features of the phenomenon, internal psychological picture of the impairment of age self-consciousness (age regression) as a variant of auto-allopsychic depersonalization are discussed.
RUDN Journal of Medicine. 2011;(3):79-81
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Malaria: current state of diagnostics and treatment
Tokmalaev А.К., Kozhevnikova G.М., Polovinkina N.А., Khodzhaeva N.М., Rabinovich S.А., Chentsov V.B.
Abstract
Status and modern ways in malaria diagnostics and treatment are reviewed. It's noticed that malaria severity and treatment efficacy, specifically for falciparum-malaria, depend on diagnostics terms as well as on timely and adequate ethyotropic and pathogenic therapy. Clinical characteristics of malaria in children based on the obtained data in endemic region in Tajikistan and approaches to optimization of treatment are described.
RUDN Journal of Medicine. 2011;(3):82-88
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Thymus and stress in the clinical history and experiment
Kuz'menko L.G., Kiseleva N.M.
Abstract
This article is dedicated to the problem of interaction between the nervous, the endocrine and immune systems based on the literature review and the author's data. Meanwhile, thymus is considered to be not only from the viewpoint of performance of the immune system, but also as the endocrine glandular making neuroimmunoendocrine interactions possible. Tactivine being a polypeptide thymus medicine impacts not only on the immune system but also displays detoxicating, mnemotropic and stress-protecting effects.
RUDN Journal of Medicine. 2011;(3):89-94
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Ethical and legal issues of hemotransfusion in surgical practice
Tarichko Y.V., Stefanov S.A., Faybushevich A.G., Maksimkin D.A.
Abstract
The article presents the ethical, legal and health problems associated with blood transfusion in surgical practice. The authors believe that practical solutions of the ethical and legal conflicts between patient and physician related to blood transfusion, is the organization of bloodless surgery centers.
RUDN Journal of Medicine. 2011;(3):95-98
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Immediate and late outcomes ofsurgial and endoscopic treatment of patients with chronic pancreatitis with a primary lesion of the head
Klimov А.Е., Маliuga V.U., Gaboian А.S., Ivanov V.А., Fedorov А.G., Davidova S.V., Barhudarov А.А., Kuprin А.А., Novoselova V.V.
Abstract
The work is based on the analysis of complex examination and treatment of 39 patients with chronic capitate pancreatitis. All patients with symptoms of obstructive jaundice underwent endoscopic intervention. In 10 (25.6%) cases pancreaticoduodenal resection (PDR) was performed, in 3 (7.7%) patients pancreaticojeunostomia (PJS) was imposed. Resection of the pancreatic head (RPH) was performed in 10 (25.6%) cases. Specific complications occurred only after the PDR and the PJS. The high level of mortality was registered after the PDR - 20%. Length of hospital stay was significantly lower after RPH. The quality of life in 28 (71.8%) patients in the late postoperative period was evaluated by the SF-36 Health Status Survey Questionnaire. The best results were registered in the patients who underwent RPH.
RUDN Journal of Medicine. 2011;(3):99-102
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Litholytic and combined therapy of urate urolithiasis
Avdoshin V.P., Rodoman V.E., Kolesnikov G.P., Andrukhin M.I., Makarov O.V., Israfilov M.N., Annenkov M.N., Pulbere S.A., Ol'shanskaya E.V.
Abstract
The estimation of efficacy of a medication «Trometamol-N» in complex therapy of urate and mixed urolithiasis, with application of extracorporeal shock wave lithotripsy (ESWL), low intensive laser irradiation is done. It was established that after such therapy dissolution of urate and mixed stones has been observed.
RUDN Journal of Medicine. 2011;(3):103-107
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Our experience of radio-waved surgery in oral and maxillo-facial region
Gun'ko V.I., Zandelov V.L., Trufanov V.D., Lezhava N.L., Uvarova E.O.
Abstract
Surgical treatment of 53 patients with various pathologies of the soft tissues of the maxillofacial region using the radio wave surgery was performed. Clinical data indicate a high efficiency of radio wave surgery in the treatment of patients with soft tissue tumors of the face and oral cavity.
RUDN Journal of Medicine. 2011;(3):108-111
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Gender characteristics of head's and neck's tumours
Antoniv V.F., Popadyuk V.I., Efimochkina K.V.
Abstract
The authors analyze factors causing the development of head's and neck's tumours and reveal gender particularities of such neoplasm.
RUDN Journal of Medicine. 2011;(3):112-115
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Long-term results of interlamellar keratoplasty for surgical correction of high myopia and astigmatism
Frolov M.A., Gonchar P.A., Barashkov V.I., Kumar V., Frolov A.M., Kazakova K.A., Morozova N.S.
Abstract
The Department of eye diseases and ophthalmology of Peoples' Friendship University of Russian has devised a method of the interlamellar circular, tunnel and sectoral keratoplasty for surgical correction of myopia and astigmatism of high degrees. In this article we have analyzed the results of our method. In total 140 operations were performed on 99 patients with follow-up period up to 13 years. 443 alloimplants were transplanted into the layers of the cornea and in 96.83% of cases (429 implants) transparent engraftment of the implants was achieved. Interlamellar keratoplasty is applied for correction of high myopia from 8.5 diopters up to 17.0 diopters; simple, complex myopic and mixed astigmatism from 3.5 diopters up to 9.5 diopters. The significant advantages of the interlamellar keratoplasty are: small trauma, lack of deep incisions of the cornea, the intact optical center of the cornea 6,0 mm, controllability of the refractive effect by replacing of alloimplants or their complete removal, if it is necessary, without any consequences for cornea.
RUDN Journal of Medicine. 2011;(3):116-120
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Prevettion of the pancreatoenteroanastomosis function impairment after pancreatogastroduodenal resection
Kharchenko N.V., Kharchenko V.P., Eltishev N.A., Kunda M.A., Zapirov G.M., Tazin V.N.
Abstract
The article is devoted to problem of pancreatic intra- and extrasecretory function impairment in patients with pancreatic cancer after a astropancreatoduodenal resection. New technical aspects of pancreatoenteroanastomosis were suggested to prevent its insufficiency.
RUDN Journal of Medicine. 2011;(3):121-125
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Reversal of neuromuscular block after surgical intervention
Butrov A.V., Magomedov M.A., Ribina D.M., Alenkina E.B.
Abstract
Results of the research on reversal by Neostigmine and suggamadex of neuromuscular block, induced by amino steroid myo-relaxants during emergency surgical interventions. Importance of the neuromuscular monitoring during Anesthesia is discussed.
RUDN Journal of Medicine. 2011;(3):126-130
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Craniomandibular pains in orthopedic stomatology. Clinical features, diagnosnosis, treatment
Bulgakov V.S., Shogokat S.S., Razumova S.N.
Abstract
Depending on localization of pain source there are somatic pain (a source is in the bone-muscular system) and visceral, arising from the internal organs. If the pain is caused by irritation of pain receptors (without their damage), it is considered to be a nociceptic pain. In case of damage of pain system struсtures it belongs to a neuropatic pain. Craniomandibulary somatogenic pain which dentists most often face are mainly nociceptic. Results of the special research conducted by us on the study of the mechanism of action and efficacy of blockades show that particularly miofascial trigger points (MTP) are the main sources of craniomandibular pains, and that injection of NSAID in МТP is an effective and safe method of arresting pain in case of miofascial pain syndrome.
RUDN Journal of Medicine. 2011;(3):131-135
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The computer оptimization of teeth restorations in the therapeutic stomatologic practice
Daurova F.U., Vayts S.V., Vayts T.V.
Abstract
At the present time more dentists realize that to conduct only artistic restoration of the teeth, even by the most modern соmposition material, it is not yet enough. It is necessary not to have only an objective information on morphologies teeth, but also about functional condition of teeth gnathology apparatus We designed computer program on recovering the morphological teeth features, algorithm of action, describing the way of the reconstruction teeth соmposition materials acoording to modern computer program and reducing the time of modeling at increasing of efficiency and quality to aesthetic restoration. The teeth restoration by author's computer program may be done as by direct as well by indirect technology.
RUDN Journal of Medicine. 2011;(3):136-139
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Oral health of children living in an orphanage
Kosyreva T.F., Arzumanyan A.G., Kuznethov V.D.
Abstract
The hygienic condition of an oral cavity, intensity and prevalence dental caries in children living in Asenevsky orphanage of the Kaluga region and without regular dental service is studied. 17 children aged from 4 until 18 years (9 boys and 8 girls) were examined. Obtained data revealed low level of oral hygiene, a high prevalence (94.1%) and intensity of dental caries (5,9%). Furthermore the analysis of stomatologic health of handicapped children of the Moscow children's boarding school № 28 for the disabled where the stomatologist works is carried out.
RUDN Journal of Medicine. 2011;(3):140-144
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Subperiosteal implantation on mandibula
Kaplan M.Z., Romanova O.V., Bikovskiy A.V., Prokopyev V.V., Kaplan B.M., Kaplan Z.M.
Abstract
The article concerns about subperiosteal implantation on mandibula. This method is the alternative one in treatment of edentulous patients. Indications, stages of treatment and complications are introduced.
RUDN Journal of Medicine. 2011;(3):145-148
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Investigations of chair of the general pharmaceutical and biomedical technology in the field of bioengineering of vegetative producers of biologically active substances
Bykov V.A., Souslina S.N., Samatadze T.E., Syomkina О.А., Khomik А.S., Volzhanova М.I., Slivkin D.А.
Abstract
Article is devoted to the complex researches of various morphological groups of raw materials, a cellular biomass and a productive part of metaboloms of vegetative superproducers of a natural and biotechnological origin. All investigations were carried out according to the Federal special purpose program «Scientific and scientific and pedagogical shots of innovative Russia» for 2009-2013, action item № 1.2.1"Carrying out of scientific researches by scientific groups under the direction of doctors of sciences», Project: «Bioengineering as a basis of mobilization of adaptive potential of bioobjects - superproducers BAS» GK П555/05.08.2009 - НК-97П.
RUDN Journal of Medicine. 2011;(3):149-152
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Change in time of spectral characteristics of drug substances (nir region)
Elizarova T.E., Morozova M.A., Pleteneva T.V.
Abstract
The changes in NIR spectra of substances resulting from the processes of natural aging were investigated. The method of discriminant analysis was used for statistical evaluation of differences between two groups of spectra - for initial and aged substances. The values obtained for the spectral range of each substance can limit the possible dispersion of the samples arisen during their aging.
RUDN Journal of Medicine. 2011;(3):153-157
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Organizational-economic aspects of innovative technologies in the field of pharmacy
Loskutova E.E., Kosova I.V., Lagutkina T.P., Dorofeyeva V.V., Teodorovich A.A.
Abstract
This article presents the basic directions of scientific researches of the department of management and economics in pharmacy in the field of use of innovative technologies, such as research of expenses for medicinal therapy of various diseases, promotion of the medical products in the pharmaceutical market, studying of consumer behavior and working out of optimum models of operating and interaction of the pharmaceutical subjects.
RUDN Journal of Medicine. 2011;(3):158-162
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Nashi avtory
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Abstract
RUDN Journal of Medicine. 2011;(3):163-175
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