No 2 (2013)

Articles
Combined toxicity of Na 2EDTA and D 2O
Burdeinaya T.N., Zrelov O.Y., Maksimova T.V., Morozova M.A., Mtei G.I., Uspenskaya E.V., Pleteneva T.V., Syroeshkin A.V.
Abstract
Physicochemical and biopharmaceutical analysis of excipients doesn’t allow to characterize them as inert components of drug products. Excipients are known to exhibit their own biological activity as well as influence the activity of API and other components of the formulation (antioxidants, stabilizers, fillers, etc.). Combined biological activity of stabilizer/antioxidant — disodium ethylenediaminetetraacetate (Na 2EDTA) — and water with different ratios of hydrogen isotopes (D / H) was studied on biological models of Spirotox. It was found that with the growth of deuterium/protium ratio in water the toxicity of Na 2EDTA increased.
RUDN Journal of Medicine. 2013;(2):5-9
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Siberian dogwood’s fruits are promising source of fatty oil
Vandishev V.V., Miroshnikova E.A., Koneva M.
Abstract
The paper deals with study of locating, content and composition of fatty oil in Siberian Dogwood’s fruits, pericarp and seed.
RUDN Journal of Medicine. 2013;(2):10-14
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Development of composition and technology of oleogel argan oil
Labzioui Z., Suslina S.N.
Abstract
The article is devoted to a comparative study of technological characteristics of argana barbed oil obtained by Soxhlet method of circulation extraction and traditional commodity pattern of oil of cosmetic purpose with the aim of obtaining oleogel and a possibility of its use as the ointment base.
RUDN Journal of Medicine. 2013;(2):15-19
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Interpretation of the pharmacoeconomical analysis in the context of rational choice of medicines
Loskutova E.E., Pak T.V., Ebzeeva A.M., Smirnov A.I., Teodorovich A.A.
Abstract
The results of a study on the use of pharmacoeconomic analysis to justify the rational choice of drug therapy and costs of the program activities for the prevention and treatment of diseases are presented. A comparative analysis of the cost of treatment of liposomal and the traditional forms of doxorubicin was conducted. Justified costs (in terms of drug provision) for realization of the program of prevention and treatment of diseases related to iodine deficiency in children in the Republic of Karachay-Cherkessia (KChR) for 2010—2015, based on the use of «default values» of expenses, received in the result of pharmacoeconomic analysis and prognosis of the disease.
RUDN Journal of Medicine. 2013;(2):20-26
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Study of consumer behavior in otc drug market
Dorofeeva V.V., Galkina G.A., Sudarenko C.V.
Abstract
The article is devoted to research of consumer behavior in the pharmaceutical market. Authors scientifically proved approaches to its investigation according to peculiarities of formation of OTC (OTC — Over The Counter) market. A method of determination of consumer satisfaction is presented and parameters of drugstore activity needing adjustment are revealed. According to loyalty target consumer segments are allocated, for each of which loyalty determinants are defined. The technique of possible development of OTC consumer behavior based on the consumer’s group requirements is offered.
RUDN Journal of Medicine. 2013;(2):27-32
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The analysis of transactional expenses in pharmacy market research
Kosova I.V., Bazarkina O.V., Ibragimova A.N.
Abstract
The term “Transactional expenses” (TE) is a key concept in the modern institutional theory. These expenses are inevitable in the interaction of economic entities, and their value determines the effectiveness of this interaction. A classification of transaction expenses and based on their analysis the method of calculation of the optimum size of pharmacy networks is developed. The formulas and coefficients of TE information search, selection of TE, TE opportunism in antacid and antiulcer medications market were offered and calculated.
RUDN Journal of Medicine. 2013;(2):33-38
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Role of pharmaceutical information in formation of competent consumer behaviour in the pharmaceutical market
Lagutkina T.P., Gribkova E.I., Kurashov M.M., Sobolenko A.K.
Abstract
Active introduction in medical practice more than one thousand new medications annually, including earlier unknown, created a situation, when understanding of pharmaceutical information and her perception by consumers determines safety use of medicines. Modern approaches and factors of safe use of medications are proved. According to the sociological research, it was established that the majority of medical, pharmaceutical experts and consumers faced this problem. Competent use of pharmaceutical information by doctors, pharmaceutical experts and consumers allows to avoid possible high risk mistakes for health and life of the patient.
RUDN Journal of Medicine. 2013;(2):39-44
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Dynamics of the body weight and vital lung capacity of the russian and foreign students
Yakunina E.B., Severin A.E., Torshin V.I., Mansur N., Geda Semu Mengista -.
Abstract
The data received from investigation of the relationship between the body weight and vital capacity of lungs of the Russian and foreign students of PFUR, who are studying in different courses. We identified their body height and weight, vital capacity of lungs and evaluated sickness rate. Analysis of the results shows that, there is a close relationship between the body weight and vital capacity of lungs in all tested individuals. However, for equal body weight, the Russian students have a greater vital capacity of lungs (average 500 ml) than the foreign ones. It revealed that during one-year adaptation to training in the University the body weight of the majority of students is increased. In Russian students with the increasing of body weight the vital capacity of lungs also elevates but in foreign students — decreases.
RUDN Journal of Medicine. 2013;(2):45-52
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Control loops card rhythm men and women with neurological disorders, connected with stress
Butova O.A.
Abstract
Defined that in males with neurological disorders associated with stress in the regulation of cardiac rhythm the autonomous circuit dominates. Females with neurologic pathology of heart rate regulation connect the third level of the center loop that characterizes intersystem homeostasis of cardio-respiratory system. Analysis of the lipid profile in men and women with neurological disorders revealed the significant increased level of low-density lipoprotein. Perhaps the accumulation of low-density lipoprotein particles, and thus the increase of their concentration in blood of patients with neurological disorders, caused by defect of low density lipoprotein receptors. In addition, peripheral muscarin-like action of acetylcholine, which manifests itself in the changing of the homeostatic properties of the endothelium, increased binding to low-density lipoproteins, leads to elevation of cholesterol fraction in the peripheral blood.
RUDN Journal of Medicine. 2013;(2):53-58
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Efficacy of cardiosynchronized electrical stimulation in patients with acute heart failure
Ivanov G.G., Orkvasov M.Y., Dvornikov V.E., Azaraksh H., Chuiko N.A., Halabi G., Muraued A.
Abstract
Objective: to study the efficacy of external cardiosynchronized muscular counterpulsation (CMC) in patients with different variants of acute heart failure. The study included the examination results of 62 patients with acute heart failure, which undergo two variants (two groups) of therapy: 1) only the standard drug therapy (diuretics, nitrates, etc .) and 2) in the case of its inefficacy over 12 hours, combination of the drug therapy with the CMC sessions over 7 days. The clinical assessment of the patients under examination characterized the group with the standard therapy as less severe. In 64% of the group 2 patients, a significant improvement in the form of improvement in the fluid balance indices was noted during the combined therapy.
RUDN Journal of Medicine. 2013;(2):59-70
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Mammaglobin mRNA expression as early breast cancer marker
Bojenko V.K., Solodky V.A., Kharchenko N.V., Trotsenko I.D., Trofimov D.Y., Kudinova E.A., Vaskevich E.F., Burmenskaya O.V.
Abstract
Early breast cancer (BC) diagnosis is a basis for overall and relapse-free survival improvement. But methods of X-ray and morphological examination sometimes are failed in BC diagnosis. New molecular markers may give more information about BC progression. One of these markers is mammaglobin. We studied 114 tissue samples: 57 I—IV stages BC samples and 57 samples of morphologically normal breast tissue (MNBT). mRNA mammaglobin expression was assessed by qPCR with reverse transcription. mRAN mammaglobin expression was significantly higher in BC samples as compared to MNBT (p = 0,0019), besides expression level decreased during BC progression: minimal level in T3 (p = 0,0338), grade 3 (p = 0,037) and stage IV (p = 0,035) tumors. hMAM expression correlated with steroid receptors (estrogen receptor, progesterone receptpor) in MNBT (p < 0.05), but not in BC tissue. hMAM mRNA expression decreased during BC progression and correlated with steroid receptors in MNBT. hMAM expression profiling may be used as a marker in BC diagnosis.
RUDN Journal of Medicine. 2013;(2):71-77
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Features of autonomic nervous system in patients with brain tumours
Lesina S.S., Nazarov R.V., Kondratyev A.N.
Abstract
Objective: to study vegetative balance at patients with brain tumors located in posterior and medium cranial fossas undergone neurosurgical operations. The analysis of cardiac rhythm variability, orthostatic test and Kerdo index were used as integrative markers of activity of vegetative nervous system. 68 patients from 17 to 71 years old were enrolled. The patients were divided into two groups depending on tumor localization. All 68 (100%) patients underwent orthostatic test using “Valenta” diagnostic system, the vegetative Kerdo index was calculated three times (before operation, after an introduction narcosis and after extubation). Daily variability of cardiac rhythm was investigated in 34 (50%) patients. The statistical analysis of results of the tests in two investigated groups had been carried out. Results: according to indicators of Kerdo index, before operation the activity of parasympathetic nervous systems dominated in patients with tumor localization both in posterior and medium cranial fossa. At calculations of Kerdo index after an introduction narcosis and after extubation the distinct tendency to a eutonia condition had been recorded. Analysis of active orthostatic test showed that in the most of the patients the minimum load (transition from a prone position in vertical standing) signs of sympatotonia prevailed. The depression of cardiac rhythm variability depended on tumor localization. More often essential decreasing of cardiac rhythm variability observed in patients with posterior fossa tumors.
RUDN Journal of Medicine. 2013;(2):78-83
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Remote results of different methods of nephropexy
Kadyrov Z.A., Kalandarov F.S., Butsko A.N., Bezuglyi O.N.
Abstract
The paper summarizes long-term results of examination and treatment of 104 patients after conventional and videoendoscopic nephropexy. It was found that video-endoscopic methods have a number of advantages, such as small trauma, shorter hospital stay, less pain, quick physical and social rehabilitation of the patient, good tolerability, and, finally, a good cosmetic effect.
RUDN Journal of Medicine. 2013;(2):84-91
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Value biomarker diagnosis and prediction of acute renal damage in patients with acute coronary syndromes without ST-segment elevation
Avdoshina S.V., Villevalde S.V., Efremovtseva M.A., Kobalava Z.D.
Abstract
Aim: to study the prognostic value of biomarkers (urine neutrophil gelatinase-associated lipocalin (uNGAL), urine interleukin-18 (uIL-18), serum cystatin C (sCysC), serum N-terminal prohormone of brain natriuretic peptide (sNT-proBNP) depending on the acute kidney injury (AKI) in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). 58 patients with NSTE-ACS were examined. Patients with NSTE-ACS and early AKI had higher sCysC, sNT-proBNP, uNGAL and uIL-18 levels than the patients without AKI. No relationship between biomarkers and in-hospital mortality was revealed in patients with cardiorenal syndrome (CRS). AKI — acute kidney injury NSTE-ACS — non-ST-elevation acute coronary syndrome CRS — cardiorenal syndrome NT-proBNP — N-terminal prohormone of Brain Natriuretic Peptide IL-18 — interleukin-18 NGAL — neutrophil gelatinase-associated lipocalin
RUDN Journal of Medicine. 2013;(2):92-95
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Safe working conditions in stomatological organizations
Maksimenko L.V., Tadjieva A.V.
Abstract
The work of dentists is characterized as a manual and presents a risk of injury to small sharp tools, the creation of bacterial aerosols and chemical use. The questioning of Moscow medical workers showed that 41% of dentists are working in hazardous conditions, 10% are not informed about the existing workplace factors hazard, while 33% did not always comply with safety rules. Classes on occupational safety spend less, and their quality is worse than in other medical institutions. Dentists had more pronounced claims to the quality of prophylactic check ups and 21% of them had work injuries. The measures for injury prevention are proposed.
RUDN Journal of Medicine. 2013;(2):96-102
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Social and organizational bases of prevention of HIV-infection
Azovtzeva O.V., Buzunova S.A., Arkhipova E.I., Nikitina N.N., Arkhipov G.S.
Abstract
HIV incidence is growing and becoming a threat to national security. The age structure is dominated by a person younger than 30 years (70.8%). There is an increase rate of HIV infection detection among pregnant women and an increasing number of children born by HIV-infected mothers. If the issues of specific prevention (preventive vaccinations), do not create any problems, the remaining questions of medical prevention are still unsolved to this day.
RUDN Journal of Medicine. 2013;(2):103-108
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Social problems of labour activity in plastic surgery
Gan’shin I.B.
Abstract
The article deals with the social problems of the plastic surgery employers. The issues of availability of useful information in workplace, wages, the prestige of the profession, professional prospects, social and psychological well-being in the medical teams, the need for additional income, the possibility to update the personnel, intra-migration, human resource mobility, care from colleagues and management, “aging workforce”, the outflow of specialty workers with higher and secondary medical education, the irrelevance of professional opinion to colleagues are discussed.
RUDN Journal of Medicine. 2013;(2):109-115
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Our authors
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Abstract
RUDN Journal of Medicine. 2013;(2):116-120
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