No 2 (2014)

Articles
Effect of local hand cooling on thermoregulation and rhythm of cardiogram of students from hot climate
Geda S.M., Torshin V.I., Severin A.E., Mansur N.
Abstract
The article presents data on changes in thermoregulation and heart rate variability due to local cooling of the hand from hot climate zone natives. Shown that a significant number of peripheral vascular spasms in response to local cooling do not occur, due to the peculiarities of thermoregulation.
RUDN Journal of Medicine. 2014;(2):5-11
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Characteristics of the circadian profile of heart rate during genetically determined hypertension
Goryachev V.A., Blagonravov M.L., Azova M.M., Velichko E.V., Trukhina E.N., Frolov V.A.
Abstract
Prevalence and importance of hypertension in the general incidence structure determines a wide range of research problems. Chronobiological indices are of great importance in the investigatory activity concerning mechanisms of essential hypertension. Our work was focused on the dynamics of HR circadian profile at different terms in male SHR rats with the use of telemetry monitoring. The obtained data showed considerable changes of cardiac rhythm in different time intervals which was understood as inhibition of the chronotropic function of the heart.
RUDN Journal of Medicine. 2014;(2):12-17
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Peculliarities of formation of supraventricular tachicardia in combination with longitudinal dissociation of ab-knot and accelerated driving and syndrome of early repolarization of ventricles
Zotova T.Y., Bondareva Y.A., Frolov V.A.
Abstract
In this paper according to the daily Holter monitoring data the analysis of possible mechanism of formation of nonparoxysmal atrial tachyarithmia is made for patients at night time.
RUDN Journal of Medicine. 2014;(2):18-23
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Morphological changes of adrenal cortex and medulla during the first 24 hours after acute hemorrhage
Yunyashina Y.V., Chekushkin A.A., Mozerov S.A., Myalin A.N.
Abstract
Experimentally established that during the first day after acute blood loss expressed morphological changes occur in the adrenal cortex and medulla, indicating a high functional stress of the organ.
RUDN Journal of Medicine. 2014;(2):24-29
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The neurotransmitter in psychogenic vomiting patients
Agadzhanyan N.A., Artem’ieva M.S., Kovaleva I.A., Kogan B.M., Filatova T.S., Drozdov A.Z.
Abstract
This article describes the clinical and neurochemical correlations for eating disorders. These peculiarities must be considered in differential diagnosis and treatment of psychogenic vomiting and anorexia nervosa with bulimic episodes. Described disturbances of catecholamine excretion indicate reduction of adaptation mechanisms in conditions of prolonged food deprivation, which is a powerful psycho-emotional stress
RUDN Journal of Medicine. 2014;(2):30-34
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The role of emotional stress in the genesis of life-hreatening heart rhythm disorders
Aleksandrova M.R., Lukashenko A.A., Yurovskaya I.I., Artem’ieva M.S.
Abstract
Personality and features of stress previous arrhythmia were studied in 70 patients with paroxysmal atrial fibrillation. A comparative evaluation was done between effectiveness of the treatment of paroxysmal atrial fibrillation by only somatotropic medications and by combination of somatotropic and psychotropic drugs.
RUDN Journal of Medicine. 2014;(2):35-41
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Renin profile in patients with untreated hypertension and its association with arterial stiffness parameters
Kravtsova O.A., Kotovskaya Y.V., Kobalava Z.D.
Abstract
The aim of the study was to evaluate relationship between patient characteristics and arterial stiffness assessed by carotid-femoral pulse wave velocity with plasma renin activity. 83 patients with untreated hypertension were examined. Patients with volume-mediated hypertension compared with patients with renin-mediated hypertension were older, had higher level of blood pressure and higher arterial stiffness.
RUDN Journal of Medicine. 2014;(2):42-45
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Expression of matrix metalloproteinase-9 and protein KI-67 at prostate tumors
Andrukhin M.I., Pul’bere S.A., Loktev A.V., Babichenko I.I.
Abstract
Iimmunohistochemical study of cells proliferative activity by Ki-67 protein and localization of matrix metalloproteinase-9 has been carried out at benign prostatic hyperplasia (BPH) and adenocarcinoma (AC) of different gradations by the Gleason score. A significant decrease of the MMP-9 levels in the AC of different gradations have been found. A moderate positive correlation between the Gleason score and cell proliferation Ki-67 index (rs = 0,674) and a moderate negative correlation with the level of such score and expression of matrix metalloproteinase-9 (rs = -0,660) were detected. A weak significant negative correlation exists also between the level of proliferative activity of secretory cells and the expression of MMP-9 by tumor cell (rs = -0,369).
RUDN Journal of Medicine. 2014;(2):46-51
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New opportunities in the diagnostics of stress state in surgical rhinology
Kastyro I.V., Popadyuk V.I., Blagonravov M.L., Grinchuk V.I.
Abstract
Continuous ECG recordings were obtained using 24-hour Holter monitors (Shiller MT-200) in 60 healthy men (50 patients with nasal septum deviation (NSD) and in 10 men of control group) aged 25 to 39 years old. Patients with NSD had a septoplasty. They were divided into five groups. Group 1 consisted of patients without analgesia. Group 2, 3, 4 and 5 patients received metamizole sodium, diclofenac, ketorolac and ketamine respectively. Control group was marked as Group 0. The monitoring began 30 minutes before surgery and ended 24 hours after record beginning. Circadian index (CI) was calculated from both heart rate (HR) and ST segment (STS) data. Simple linear regression was performed between HR-derived and STS-derived CIs for each groups. Inter-groups Student's t-test was calculated. Obtained coefficients of determination varied from 0.60 to 0.87. STS- and HR-derived CIs were only statistically inequivalent in Group 1 (p < 0.05). Inter-groups analysis showed that 0 and 3 Groups were statistically equivalent and there was CI decrease in groups 4 and 5 (p<0.05). Tendency to decrease CI observed in Group 2. CI can be calculated not only heart rate, but also by the deviation of CST, which indicates the importance of CST not only as ischemia marker but also as an indicator of autonomic nervous system arousal.
RUDN Journal of Medicine. 2014;(2):52-57
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Long-term results of cholecystectomy
Medvedev A.M.
Abstract
Followed up the results of cholecystectomy for 10 years after the surgery. Consequences of cholecystectomy were assessed by measuring plasma levels of bile acids, the level of pressure in the stomach and duodenum, changes in the pancreas and stomach. Found that for ten years plasma levels of lithocholic, deoxyholic and taurodeoxyholic acids were increased by 44%. At the same time, the content of glycocholic and tauroursodeoxyholic acids decreased by 21.5% in 5 years after the surgery. Changes in plasma levels of bile acids associated with the changes of pressure in the stomach and duodenum. Revealed that the most marked deviations were observed in the distal duodenum. Pressureу level in this area exceeded the norm by more than 2.8 times. Increased pressure in the intestine accompanied by dilation of pancreatic ducts in 9.5% of cases and increased ultrasound echogenicity of the structure in 93% of cases. In all the cases, lymphofollicular hyperplasia of gastric antral mucosa with a high degree of Helicobacter pylori contamination was detected.
RUDN Journal of Medicine. 2014;(2):58-63
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Prognostic value of blood flow in prostate in patients with benign prostatic hyperplasia with urine retention
Atamanova E.A., Andryukhin M.I., Makarov O.V.
Abstract
Benign prostatic hyperplasia (BPH) is the most frequent disease among men of middle-aged, older, associated with increasing of lifetime of men and diagnosed in 42% to 87%. The purpose of our study is to improve the diagnosis of BPH without complications and with urine retention. Transrectal sonography was performed in 77 patients with BPH with assessment of blood flow by Doppler. The speed of blood flow measured in subcapsular and paraurethral arteries with estimation of diameter and speed of vein drain into the paraprostatic veins. Transrectal sonography showed the changes of the prostatic blood-flow especially in case of BPH with urine retention. Transrectal ultrsonography plays an important role in evaluation of the prostatic blood-flow.
RUDN Journal of Medicine. 2014;(2):64-69
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Statistics of preeclampsia and eclampsia with contemporary parameters of registration of births
Frolova O.G., Pavlovich S.V., Grebennik T.K.
Abstract
Statistical data analysis on preeclampsia and eclampsia during all stages of pregnancy, as well as childbirth and postpartum period allows to develop a system of preventive measures and treatment based on the experience of the Russian Federation subjects with low levels of preeclampsia and eclampsia and reproductive losses.
RUDN Journal of Medicine. 2014;(2):70-74
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Abortion in the Republic of Bashkortostan
Sharafutdinova N.H., Mustafina G.T.
Abstract
The article deals with the problem of abortion in the Republic of Bashkortostan. Established reduction of abortion rate of 46.4% from 2003 to 2012, more significant in 2005-2007. Dynamics analysis showed decreasing of abortions in all age groups, except of 35-39 years old group. However, at the age of 15-17 years a positive trend was not so evident. Of all abortions in the Republic of Bashkortostan was 7.2% in primiparous, 92.9% were terminated before 12 weeks of pregnancy, increasing with the age. The rate of abortions of 12-21 weeks was the highest in the grope of 15-19 aged women, consequently 8.4%. During 2010-2012 years 30.0% of abortions were performed in the early terms of pregnancy and 16.6% of them - pharmacological. The proportion of women terminated pregnancy in the early terms was highest in group of 25-29 years (31.7%) and 30-34 years (32.6%) old women. The average age of women who terminated pregnancy was 28,76 ± 0,96 years.
RUDN Journal of Medicine. 2014;(2):75-82
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Modern principles of conservative treatment of pulpitis
Nikolskaya I.A.
Abstract
In Russia the number of patients with inflammatory diseases of a tooth pulp, according to various authors ranging from 20,6% to 46,3% of the number of the dental patients. In the treatment of reversible forms of pulpitis, along with the use of medications for direct pulp capping in the range of therapeutic interventions include various physical factors contributing to relief of inflammation and increase the regenerative possibility of tissue, but our study demonsrtated that a small number of doctors apply it in everyday dental practice.
RUDN Journal of Medicine. 2014;(2):83-88
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Specific features of noninvasive diagnostics of local balance immunity in infalammatory chronic parodontal diseases in young individuals living in the region with hazardous environment
Usmanova I.N., Gerasimova L.P., Kabirova M.F., Khusnarizanova R.F., Usmanov I.R.
Abstract
A noninvasive method for diagnosis of chronic inflammatory periodontal diseases predicts a level of serious disorders of the oral local immunity, diagnose early changes in periodontal tissues, and timely perform preventive measures in young individuals living in the region with hazardous environment.
RUDN Journal of Medicine. 2014;(2):89-94
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Anticancer activity of a new pharmaceutical composition of diindolylmethane by inhibiting the cell viability in vitro
Kiselev V.I., Drukh V.M., Pchelintseva O.I., Kuznetsov I.N., Muyzhnek E.L., Gorbunova E.A.
Abstract
We have studied antitumor effects of a new pharmaceutical composition with improved bioavailability containing 3,3’-diindolylmethane (DIM) by in vitro modelling. Cytotoxicity of the test substance was determined by MTT assay. Pharmaceutical composition based on DIM inhibits the growth of tumor cell lines of endometrial cancer CRL-1622 (IC50 = 41,9 µM) and HTB-113 (IC50 = 52,2 µM). Results of the study allow to recommend the further investigation of antitumor activity in vivo .
RUDN Journal of Medicine. 2014;(2):95-101
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Technique of computed tomography and evaluation of the efficacy of targeted therapy for metastatic renal cell carcinoma by RECIST criteria
Klimenko A.A., Kotlyarov P.M., Ivanov S.A., Egorova E.V., Sherbakhina E.V.
Abstract
This article describes a technique of spiral CT, the results of which and through international response evaluation criteria conducted targeted therapy in treatment of patients with metastatic kidney cancer therapeutic tactics standardized reference this category of patients. As a result of diagnostic and therapeutic measures increases the efficiency of therapy and increases overall survival of patients with metastatic kidney cancer.
RUDN Journal of Medicine. 2014;(2):102-109
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Automation of pharmacoeconomic evaluation of the rationality of prescribing and its today’s relevance
Pavlov D.V., Shakirova D.K.
Abstract
This article discusses the presence of opportunistic infection - viral hepatitis C in HIV-infected patients and the treatment difficulties of such patients. Given the amount of funding spent on the provision of medical assistance to HIV positive patients with viral hepatitis C. Emphasized the need for a computer product to optimize management processes using the drug.
RUDN Journal of Medicine. 2014;(2):110-113
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Some safety aspects of a new russian pegylated interferon-A medication “ALGERON” (phase 1 clinical trial)
Tukach A.I., Fitilev S.B., Shkrebniova I.I., Vozzhaev A.V., Yakushev V.A., Ivanov R.A., Lin’kova Y.N., Chernovskaya T.V.
Abstract
Treatment of hepatitis C is one of the most acute international healthcare problems. High standard in management of patients with HCV virus is combined therapy with pegylated interferon-a plus ribavirin. A necessity to develop new medications and to improve current treatment regiments is determined by high social and economic significance of this disease. Safety and tolerance assessment in healthy volunteers, definition of maximum tolerated dose are conducted in first phase clinical trial of original, Russian medication - pegylated interferon-a, named Algeron (INN - Cepeginterferon alfa-2b). Step by step dose escalation of Algeron in groups of several healthy volunteers was applied in this trial. Results of this trial demonstrated, that safety profile of Algeron has no significant differences with safety profiles of analogical pegylated interferon-a medications. Thus Algeron can be recommended for the second phase clinical trials.
RUDN Journal of Medicine. 2014;(2):114-118
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Abstract
RUDN Journal of Medicine. 2014;(2):119-123
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