Gene expression analysis of proliferation and apoptosis depending on the status of steroid hormone receptors in breast cancer

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  • Authors: Bozhenko VK1, Kudinova EA1, Kharchenko NV2, Zapirov GM2, Trotsenko ID2
  • Affiliations:
    1. Russian Scientific Center of Roentgen radiology
    2. People Friendship University of Russia
  • Issue: No 4 (2013)
  • Pages: 10-19
  • Section: Articles
  • URL: http://journals.rudn.ru/medicine/article/view/3355
  • Cite item

Abstract


In normal cell apoptosis and proliferation are strictly controlled by intra- and extracell mechanisms. These signals interfere with cell pathways through cell receptors, estrogen, progesterone, HER2/neu receptors in the case of breast cancer. Expression of apoptotic and proliferative genes is different in breast cancer depending on hormonal status. Besides correlation analysis shows different role of cell receptors in proliferation control in normal and breast tissue.

About the authors

V K Bozhenko

Russian Scientific Center of Roentgen radiology

Email: vbojenko@mail.ru
Federal State Institute

E A Kudinova

Russian Scientific Center of Roentgen radiology

Email: ekudinova@mail.ru
Federal State Institute

N V Kharchenko

People Friendship University of Russia

Email: nkharchenko@mail.ru
Oncology department

G M Zapirov

People Friendship University of Russia

Email: zapirov@mail.ru
Oncology department

I D Trotsenko

People Friendship University of Russia

Email: trotsenkoivan@mail.ru
Oncology department

References

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Copyright (c) 2013 Боженко В.К., Кудинова Е.А., Харченко Н.В., Запиров Г.М., Троценко И.Д.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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