Gene expression analysis of proliferation and apoptosis depending on the status of steroid hormone receptors in breast cancer

V K Bozhenko; Боженко Владимир Константинович; E A Kudinova; Кудинова Елена Александровна; N V Kharchenko; Харченко Наталья Владимировна; G M Zapirov; Запиров Гаджимурад Магомедович; I D Trotsenko; Троценко Иван Дмитриевич

Gene expression analysis of proliferation and apoptosis depending on the status of steroid hormone receptors in breast cancer

Authors: Bozhenko VK¹, Kudinova EA¹, Kharchenko NV², Zapirov GM², Trotsenko ID²
Affiliations:
1. Russian Scientific Center of Roentgen radiology
2. People Friendship University of Russia
Issue: No 4 (2013)
Pages: 10-19
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3355

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Abstract

In normal cell apoptosis and proliferation are strictly controlled by intra- and extracell mechanisms. These signals interfere with cell pathways through cell receptors, estrogen, progesterone, HER2/neu receptors in the case of breast cancer. Expression of apoptotic and proliferative genes is different in breast cancer depending on hormonal status. Besides correlation analysis shows different role of cell receptors in proliferation control in normal and breast tissue.