Genetic factors for development thrombophilia in pregnant

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Abstract


The results of studying the frequency of genetic polymorphism of receptor subunits platelet GP IIb/IIIa in 408 pregnant women.
It was found that in women with thrombophilia normal variant of the gene occurred in 63.6%, heterozygous mutation - in 21%, homozygous mutation - in 15,2% of cases. In healthy women heterozygous mutation was revealed in 15,7%, normal genotype - in 84,3% and homozygous mutations was not detected at all. The connection between the occurrence of clinical manifestations of thrombophilia and the presence of hetero- and homozygous mutations of the subunits of platelet receptor GP IIb/IIIa was shown.

T P Bondar

Stavropol State University

Email: sonu@live.ru
Кафедра физико-химических основ медицины,лабораторной диагностики и фармакологииМедико-биолого-химический факультет; Ставропольский государственный университет; Stavropol State University

A Y Muratova

Stavropol State University

Email: sonu@live.ru
Кафедра физико-химических основ медицины,лабораторной диагностики и фармакологииМедико-биолого-химический факультет; Ставропольский государственный университет; Stavropol State University

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Copyright (c) 2012 Бондарь Т.П., Муратова А.Ю.

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