The polymorphism c677t of the gene MTHFR correlates with the complications of the coronary heart disease and arterial hypertension for the patients with dislipidaemia

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Abstract


The present study was designed to determine the possibility of the application the genotyping of the patients with dislipidaemia as an additional factor for the prediction of the cardiovascular complications. The distribution of the polymorphism C677T of the gene MTHFR among the 62 patients with dislipidaemia was studied. Allele-specific PCR was applied for detection the C677T mutation/ These results provide the genetic evidence that 677T allele of the gene MTHFR correlates with the development of the complications of the coronary heart disease for the patients with dislipidaemia (p = 0,01). It was demonstrated that more complex and durable antihypertension and cardiotropic therapy must be applicated for the carries of the 677T allele among the dislipidaemia patients. These data indicate the appreciable role C677T polymorphism of MTHFR for the decreasing of the cardiovascular complications among the patients with dislipidaemia and for detection the complexity and longevity of the medical treatments.

G I Myandina

Peoples Friendship University of Russia

Email: rudnvestnik@yandex.ru
Кафедра биологии и общей генетикиМедицинский факультет; Российский университет дружбы народов; Peoples Friendship University of Russia

E N Kasapova

Peoples Friendship University of Russia

Email: ekasapova@mail.ru
Кафедра биологии и общей генетикиМедицинский факультет; Российский университет дружбы народов; Peoples Friendship University of Russia

T U Zotova

Peoples Friendship University of Russia

Email: Zotovat@mail.ru
Кафедра общей патологии и патологической физиологииМедицинский факультет; Российский университет дружбы народов; Peoples Friendship University of Russia

V A Frolov

Peoples Friendship University of Russia

Email: rudnvestnik@yandex.ru, frolov@medl.rudn.ru
Кафедра общей патологии и патологической физиологииМедицинский факультет; Российский университет дружбы народов; Peoples Friendship University of Russia

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Copyright (c) 2012 Мяндина Г.И., Касапова Е.Н., Зотова Т.Ю., Фролов В.А.

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