Expression of matrix metalloproteinase-9 and protein KI-67 at prostate tumors

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Abstract


Iimmunohistochemical study of cells proliferative activity by Ki-67 protein and localization of matrix metalloproteinase-9 has been carried out at benign prostatic hyperplasia (BPH) and adenocarcinoma (AC) of different gradations by the Gleason score. A significant decrease of the MMP-9 levels in the AC of different gradations have been found. A moderate positive correlation between the Gleason score and cell proliferation Ki-67 index (rs = 0,674) and a moderate negative correlation with the level of such score and expression of matrix metalloproteinase-9 (rs = -0,660) were detected. A weak significant negative correlation exists also between the level of proliferative activity of secretory cells and the expression of MMP-9 by tumor cell (rs = -0,369).

About the authors

M I Andrukhin

Peoples’ Friendship University of Russia

Email: valeriya-andrew@mail.ru
Department of Urology

S A Pul’bere

Peoples’ Friendship University of Russia

Email: valeriya-andrew@mail.ru
Department of Urology

A V Loktev

Peoples’ Friendship University of Russia

Email: valeriya-andrew@mail.ru
Department of Urology

I I Babichenko

Peoples’ Friendship University of Russia

Email: valeriya-andrew@mail.ru
Department of Pathological Anatomy

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Copyright (c) 2014 Андрюхин М.И., Пульбере С.А., Локтев А.В., Бабиченко И.И.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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