Comprehensive analysis of the laboratory examination results of patients with an established bronchial asthma diagnosis

Cover Page


Relevance. Bronchial asthma is a serious medical and social problem. To confirm the diagnosis, it is necessary to assess the allergic status, to determine the biological markers of the disease. Of particular relevance is a comprehensive analysis of the results of laboratory examination of patients, including data from hematological, immunological, microbiological studies. Aim. To study some laboratory parameters (hematological, immunological and microbiological), the changes of which are most typical for patients with an established diagnosis of bronchial asthma. Matherials and Methods . A clinical and diagnostic examination of women in the non-production and industrial sectors with an established diagnosis of bronchial asthma, performed during a periodic medical examination, was carried out. Results and Discussion . Laboratory research has shown that hematological parameters are characterized by a reduced content of hemoglobin, erythrocyte indices MCV, MCH, MCHS - markers of hypochromia. The surveyed women had increased indices: eosinophils, immunoglobulin E, allergy index, leukocyte intoxication index. High rates of allergization are found in the production sector in 41,51%, in the non-production sector - in 44,44%, which indicates a serious sensitization of the body. Bacterial contamination in the examined groups is represented by coccal flora, where the most significant microorganisms are Staphylococcus aureus, Staphylococcus spp, Streptococcus pyogenes and Candida albicans. Conclusion . The results of the analysis indicate the need to conduct and study further research on the development of markers of early, prenosological health disorders in the process of screening examination of large groups of the working population.

About the authors

Elena R. Abdrakhmanova

Ufa Research Institute of Occupational Medicine and Human Ecology; Bashkir State Medical University

Author for correspondence.
ORCID iD: 0000-0003-2763-1358
Ufa, Russian Federation

Natalya V. Vlasova

Ufa Research Institute of Occupational Medicine and Human Ecology

ORCID iD: 0000-0003-3926-0937
Ufa, Russian Federation

Lyaylya M. Masyagutova

Ufa Research Institute of Occupational Medicine and Human Ecology; Bashkir State Medical University

ORCID iD: 0000-0003-0195-8862
Ufa, Russian Federation

Liliya G. Gizatullina

Ufa Research Institute of Occupational Medicine and Human Ecology

ORCID iD: 0000-0001-6593-2704
Ufa, Russian Federation

Linara A. Rafikova

Ufa Research Institute of Occupational Medicine and Human Ecology

ORCID iD: 0000-0002-7355-9556
Ufa, Russian Federation

Guzel M. Chudnovets

Ufa Research Institute of Occupational Medicine and Human Ecology

ORCID iD: 0000-0002-5807-2037
Ufa, Russian Federation


  1. Cristina E, Mapp CE, Boschetto B, Maestrelli P. et all. Occupational Asthma. Am J Respir Crit Care Med. 2005;172:280—305.
  2. Inoue N, Watanabe M, Morita M. et all. Association of functional polymorphisms in promoter regions of IL5, IL6 and IL13 genes with development and prognosis of autoimmune thyroid diseases. Clinical and Experimental Immunology. 2011;163:318—323.
  3. Kabesch M, Depner M, Dahmen I. et all. Polymorphisms in eosinophil pathway genes, asthma and atopy. Allergy. 2007;62:423—428.
  4. Lemeshev AF. Diagnosis of bronchial asthma. Health care. 2012;3:46—50. (In Russ).
  5. Il’in AV. Sovremennye metody diagnostiki bronhial’noj astmy (obzor literatury). Byulleten’ fiziologii i patologii dyhaniya. 2012. N43. S.116—123. (In Russ).
  6. Timasheva GV, Valeeva OV, Badamshina GG, Fagamova AZ. Integral’nye gematologicheskie pokazateli i ih ispol’zovanie v diagnostike toksicheskogo vliyaniya himicheskih faktorov na organizm rabotnikov sovremennogo himicheskogo proizvodstva. Vserossijskaya nauchno-prakticheskaya konferenciya molodyh uchenyh i specialistov nauchno-issledovatel’skih organizacij Rospotrebnadzora «Aktual’nye problemy profilakticheskoj mediciny, sredy obitaniya i zdorov’ya naseleniya». Ufa; 2013: 207—212. (In Russ).
  7. Metodicheskie ukazaniya 4.2.2039—05 «Tekhnika sbora i transportirovaniya biomaterialov v mikrobiologicheskie laboratorii». 2005. (Access date: 19.11.2020). (In Russ).
  8. Labinskaya AS, Kostyukova NN. Rukovodstvo po medicinskoj mikrobiologii. Chastnaya medicinskaya mikrobiologiya i etiologicheskaya diagnostika infekcij; Binom, 2010. (In Russ).
  9. Prikaz № 535 MZ SSSR «Ob unifikacii mikrobiologicheskih (bakteriologicheskih) metodov issledovaniya, primenyaemyh v klinikodiagnosticheskih laboratoriyah LPU ot 22.04.1985. (In Russ).
  10. Mummadi SR. et al. Clinically significant variability of serum Ig E concentrations in patients with severe astma. J Astma. 2012;4(2):42—47.
  11. Pozdnyakova OYu, Baturin VA. Struktura bakterial’noj infekcii u pacientov s bronhial’noj astmoj. Kubanskij nauchnyj medicinskij vestnik. 2012. N4(133). S.80—82. (In Russ).
  12. Imetova ZhB, Kalmatov RK, Abdurahmanov BO, Belov GV, Kletochnye i mikrobiologicheskie pokazateli slizistoj obolochki verhnih dyhatel’nyh putej u pacientov s rekurrentnymi respiratornymi infekciyami i bronhial’noj astmoj. Molodoj uchenyj. 2018;47(233):207—212. URL: (Access date: 19.11.2020). (In Russ).
  13. Fedoseev GB, Trofimov VI, Rogacheva NN, Razumovskaya TS. The role of neutrophils and bacterial infection of the respiratory tract in patients with bronchial asthma and chronic obstructive pulmonary disease. Russian Journal of Allergy. 2011;2:34—43. (In Russ).



Abstract - 69

PDF (Russian) - 73




Copyright (c) 2021 Abdrakhmanova E.R., Vlasova N.V., Masyagutova L.M., Gizatullina L.G., Rafikova L.A., Chudnovets G.M.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies