The biological factors influence alcoholic liver disease progression

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Abstract

The aim of study was to detect the genetic factors which cause the predisposition for alcoholic liver damage. The main candidate genes of high risk are isoforms of adh and aldh genes which are responsible for different rate of alcohol metabolism and oxidation of ethanol and acetaldehyde. Our results demonstrated that allelic variant adh 2-2 is in a higher frequency in patients with alcoholic liver damage than in a population (16% vs. 7%; p < 0,05). The polymorphism t 174 m of angiotensinogen gene AGT was studied as risk factor of alcoholic liver damage. The allelic variant т of angiotensinogen gene AGT is more frequent (15,8%) in patients with alcoholic liver cirrhosis and alcohol abuse without cirrhosis (n = 98) than in a population (6,7%, n = 52; p = 0,04). the greater frequency of allele m was in a group with alcoholic liver cirrhosis (17,3%; p = 0,058). Our. data provides the evidence that polymorphism t 174 m of AGT gene does not influence the progression (clinical picture) of alcoholic liver cirrhosis, except the level of GGT, which is increased in patients with homozygous genotype tt.

About the authors

P P Ogurtsov

Peoples Friendship University of Russia

Email: pogurtsov@yandex.ru
Department of Hospital Medicine and Department of Вiology and General Genetics Medical faculty

I V Garmash

Peoples Friendship University of Russia

Email: igarmash@bk.ru
Department of Hospital Medicine and Department of Вiology and General Genetics Medical faculty

A E Guschin

FBUN Epidemiology Research Institute

Email: Aguschin@pcr.ru
Laboratory of Molecular diagnosis and epidemiology of infections reproductive organs

E V Tarasenko

Peoples Friendship University of Russia

Email: tarasenkoev@inbox.ru
Department of Hospital Medicine and Department of Вiology and General Genetics Medical faculty

G I Myandina

Peoples Friendship University of Russia

Email: gmyand@mail.ru
Department of Hospital Medicine and Department of Вiology and General Genetics Medical faculty

O S Arisheva

Peoples Friendship University of Russia

Email: olda.arisheva@yandex.ru
Department of Hospital Medicine and Department of Вiology and General Genetics Medical faculty

T S Polikarpova

Peoples Friendship University of Russia

Email: tania.nicolaeva@rambler.ru
Department of Hospital Medicine and Department of Вiology and General Genetics Medical faculty

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Copyright (c) 2013 Огурцов П.П., Гармаш И.В., Гущин А.Е., Тарасенко Е.В., Мяндина Г.И., Аришева О.С., Поликарпова Т.С.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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