Synthesis and anaigetical activity of derivatives of 1-indolilethil-3-pirrolin-2-ones

Cover Page

Abstract


Interaction of methyl esters of acylpyruvic acides with mixture of aromatic aldehyde and tryptamine or 5-methoxytryptamine leads to 5-aryl-4-acyl-3-hydroxy-1-[2-(3-indolil)-ethyl)-2,5-dihydropyrrol-2-ones (I). The compounds (I) were transformed to 3,4-diaryl-1,4,5,6-tetrahydro-6-oxo-5-(2-(3-indolil)-ethyl)pyrrolo[3,4-c]pyrazoles (II) by reaction with hydrazine-hydrate. The structure of received compounds is established. The analgetical activity of compounds (I б-е) and (II) is investigated.

About the authors

N V Dozmorova

Perm state pharmaceutical academy

Email: somvoz@live.ru <mailto:somvoz@live.ru>
Perm state pharmaceutical academy

V L Gein

Perm state pharmaceutical academy

Email: somvoz@live.ru <mailto:somvoz@live.ru>
Perm state pharmaceutical academy

N N Kasimova

Perm state pharmaceutical academy

Email: somvoz@live.ru <mailto:somvoz@live.ru>
Perm state pharmaceutical academy

L I Varkentin

Perm state pharmaceutical academy

Email: somvoz@live.ru <mailto:somvoz@live.ru>
Perm state pharmaceutical academy

B Ya Syropyatov

Perm state pharmaceutical academy

Email: somvoz@live.ru <mailto:somvoz@live.ru>
Perm state pharmaceutical academy

N V Danilova

Perm state pharmaceutical academy

Email: somvoz@live.ru <mailto:somvoz@live.ru>
Perm state pharmaceutical academy

References

Statistics

Views

Abstract - 95

PDF (Russian) - 41

Cited-By



Copyright (c) 2009 Дозморова Н.В., Гейн В.Л., Касимова Н.Н., Варкентин Л.И., Сыропятов Б.Я., Данилова Н.В.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies