Diagnostics of the hepatic fibrosis and cirrhosis in children by means of serum markers

Cover Page

Abstract


Possibilities of application of hyaluronic acid and type IV collagen levels in serum for noninvasive diagnostics of various stages of hepatic fibrosis in children with chronic liver diseases are studied. It is established that serum concentration of these biochemical markers significantly change at the expressed sclerotic processes in hepatic tissue. Hyaluronic acid and type IV collagen are reliable noninvasive markers of severe fibrosis and cirrhosis of liver, can be used in pediatric practice for specification of a stage of process in hepatic parenchyma at impossibility of carrying out liver biopsy, and also for an estimation of dynamics of fibrosis and monitoring of efficiency of therapy at chronic liver diseases.

A N Surkov

Scientific Center of Children's Health

Email: somvoz@live.ru <mailto:somvoz@live.ru>
Научный центр здоровья детей РАМН; Scientific Center of Children's Health

A S Potapov

Scientific Center of Children's Health

Email: somvoz@live.ru <mailto:somvoz@live.ru>
Научный центр здоровья детей РАМН; Scientific Center of Children's Health

I E Smirnov

Scientific Center of Children's Health

Email: somvoz@live.ru <mailto:somvoz@live.ru>
Научный центр здоровья детей РАМН; Scientific Center of Children's Health

A G Kucherenko

Scientific Center of Children's Health

Email: somvoz@live.ru <mailto:somvoz@live.ru>
Научный центр здоровья детей РАМН; Scientific Center of Children's Health

T S Chetkina

Scientific Center of Children's Health

Email: somvoz@live.ru <mailto:somvoz@live.ru>
Научный центр здоровья детей РАМН; Scientific Center of Children's Health

O F Tatyanina

Scientific Center of Children's Health

Email: somvoz@live.ru <mailto:somvoz@live.ru>
Научный центр здоровья детей РАМН; Scientific Center of Children's Health

Views

Abstract - 45

PDF (Russian) - 45


Copyright (c) 2009 Сурков А.Н., Потапов А.С., Смирнов И.Е., Кучеренко А.Г., Четкина Т.С., Татьянина О.Ф.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.