Morphological Features of the Burn Wound of Skin at Rats Against the Background of Correction by Stimulators of the Reparation of Tissues

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Abstract


In article morphological features of skin of rats in the conditions of burn influence of skin without use of medicines and against the background of correction are studied by pharmaceuticals. A research objective was studying of morphological features of skin wounds of rats in the conditions of a thermal trauma and against the background of their correction was stimulators of a reparation of tissues. Materials and methods. As an object of a research served exemplars of the defective skin of non-linear rats males ( n = 50) excised from a zone of a thermal trauma in interscapular area of a back. The thermal burn of skin was caused imposing of a copper subject. Beginning from first day after a trauma put appliques of stimulators of a reparation of tissues daily during the entire period of an experiment. Results. Thermal influence led to development of the significant degenerative and dystrophic changes in skin. Restitution of a burn wound of skin of rats proceeded as the delayed partial reparative regeneration which is followed by the destructive phenomen and formation of cicatricial tissues. Conclusion. Application of stimulators of a reparation of tissues (cream Spacatel, spray D-pantenol) as means of correction of wound defects of skin promoted delay of the destructive processes within a false skin, a derma and a hypodermic fatty tissue, to an adhesion of a zone of damage (formation of tissues of skin and a cuticularization of a wound), in comparison with a case of correction of burn wounds of skin appliques of extraction alcoolique by Calendulae. Positive takes of our research prove effectiveness of their application in dermatologic and traumatology practice.


About the authors

A. K. Azhikova

Astrakhan State Medical University

Author for correspondence.
Email: alfia-imacheva@mail.ru
Astrakhan, Russia

N. N. Fedorova

Astrakhan State Technical University

Email: alfia-imacheva@mail.ru
Astrakhan, Russia

G. F. Zhuravleva

Astrakhan State University

Email: alfia-imacheva@mail.ru
Astrakhan, Russia

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