CLINICAL AND DIAGNOSTIC VALUE OF THE DETERMINANTION OF FRACTALKINE IN ATOPIC DERMATITIS OF CHILDREN

Cover Page

Abstract


In recent years there has been an increase in the incidence of atopic dermatitis in children. However, despite numerous studies, still remains the problem of objective laboratory diagnosis of this disease, and, respectively, rational pharmacotherapy. Aim. The aim of the study was to improve the diagnostics of allergic skin diseases in children. Materials and methods: the study included 135 children with atopic dermatitis and 29 children in the control group. Clinical and laboratory examination of patients was carried out in accordance with the standards of diagnosis of atopic dermatitis. Additionally, we determined the level fractalkine in blood serum using enzyme immunoassay kit for the quantitative determination fractalkine in biological fluids. Results. For most patients with Ad were a characteristic increase in the level fractalkine in blood serum depending on the severity of the disease. The highest concentrations of the studied CC chemokine is characteristic of severe process. Conclusions. Definition fractalkine in the serum can be used as an indicator of the severity of the pathological process and predicting its future course.


About the authors

M M Ben

Astrakhan State Medical University

Author for correspondence.
Email: apteca-111a@mail.ru

E Ya Yanchevskaya

Astrakhan State Medical University

Email: apteca-111a@mail.ru

O A Mesnyankina

Astrakhan State Medical University

Email: apteca-111a@mail.ru

References

  1. Batyrshina S.V., Haertdinova L.A., Halilova R.G., Sabynina E.E. Microbiocenosis skin of patients with atopic dermatitis and its correction. Prakticheskaja medicina. 2013. 1—4 (73):33—37 (In Russ).
  2. Haertdinova L.A., Mingazova Je.N., Glushko N.I., Malanicheva T.G. Analysis of the structure of the skin microbiocenosis in children with atopic dermatitis. Kazanskij medicinskij zhurnal. 2005. 86 (6):489—490 (In Russ).
  3. Kubanova A.A., Kubanov A.A., Melehina L.E., Bogdanova E.V. Dermatovenereology in the Russian Federation. Success, achievement. The main ways of development. Vestn dermatol venerol. 2015. 4:1326 (In Russ).
  4. Kochergin N.G. Atopic dermatitis: modern aspects of pathogenesis and therapy. Russkij medicinskij zhurnal. 2004. 12(18):1076—1083 (In Russ).
  5. Kungurov N.V., Gerasimova N.M., Kohan M.M. Atopic dermatitis: types of flow, the principles of therapy. Ekaterinburg, 2000. 267 s. (In Russ).
  6. Malanicheva T.G., Salomykov D.V., Agafonova E.V. The state of phagocytic activity of neutrophils in atopic dermatitis in children complicated by mycotic infection. Allergologija i immunologija. 2003. 4:162—163 (In Russ).
  7. Logunov O.V., Bashkina O.A., Krasilova E.V. Evaluation of risk factors for complicated course of atopic dermatitis in children. Astrahanskij medicinskij zhurnal. 2011. T. 6. № 3. S. 185—187 (In Russ).
  8. Chong S., Lan H., Zeng K., Zhao X. Serum Fractalkine (CX3CL1) Concentration Correlates with Clinical Severity in Pediatric Atopic Dermatitis Patients. Ann. Clin. Lab. Sci. 2016. 46 (2):168—73.
  9. Balabanian K., Foussat A., Dorfmuller P., Durand-Gasselin I., Capel F., Bouchet-Delbos L. et al. CX3C chemokine fractalkine in pulmonary arterial hypertension. Am. J. Respir. Crit. Care. Med. 2002. 165 (10):1419—1425.
  10. Mesnyankina O.A., Janchevskaja E.Ju., Ben M.M. Fractalkine: pathogenic role and diagnostic capabilities. Kubanskij nauchnyj medicinskij vestnik. 2017. 2(163): 148—151 (In Russ).
  11. Polunina E.A., Sevost'janova I.V., Voronina L.P., Polunina O.S., Mitrohina D.S. The relationship between enhanced level fractalkine and dysfunction of the vascular endothelium in chronic heart failure. Astrahanskij medicinskij zhurnal. 2014. 9(2):69—74 (In Russ).
  12. Sevost'janova I.V., Polunina O.S., Voronina L.P., Perova N.Ju., Beljakova I.S., Polunina E.A. The effect of cytokines with chemotactic properties on the vascular endothelium in bronchial asthma. Astrahanskij medicinskij zhurnal. 2014. 9(3):56—62 (In Russ).
  13. Zhuravljova L.V., Lopina N.A. The level of fractalkan and its significance in predicting the presence and severity of atherosclerotic lesion of coronary vessels. Ukrainskij kardiologichesikj zhurnal. 2016. № 4. С. 62—67 (In Russ).
  14. Julia V., Staumont-Salle D., Dombrowicz D. Role of fractalkine/CX3CL1 and its receptor CX3CR1 in allergic diseases. Med Sci (Paris). 2016. 32(30):260—266.
  15. Kim J., Cho D., Park H. Molecular mechanisms of cutaneous inflammatory disorder atopic dermatitis. Int. J. of Molecular Sciences. 2016. 17(8):1234.
  16. Federal clinical recommendations. Dermatology 2015: diseases of the skin. Of sexually transmitted infections. M.: Delovoj jekspress, 2016 (In Russ).

Statistics

Views

Abstract - 277

PDF (Russian) - 204

Cited-By


PlumX

Dimensions


Copyright (c) 2018 Ben M.M., Yanchevskaya E.Y., Mesnyankina O.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies