Association between polymorphism gene ABCB1, encodes glycoprotein P, and efficacy and safety profile of haloperidol in patients with alcohol addiction

Abstract


Haloperidol is used in the practice of drug for relief of updating drives in patients suffering from a pathological attraction to alcohol, but the empirical selection of its dosage often leads to the development of patient adverse drug reactions. Synthesis of glycoprotein P, involved in the excretion of various xenobiotics including haloperidol encoded ABCB1 gene having a high level of polymorphism. Various ABCB1 allelic variations are associated with varying degrees of activity of glycoprotein P. Polymorphism 3435C>T is the functional polymorphism, which makes the activity of glycoprotein P slowly, that’s why its increase the level of concentration of xenobiotics (substrates of glycoprotein P) in blood-plasma and increase the risk of adverse drug reactions. Efficacy and safety of treatment with haloperidol was determined by international psychometric scales and scales for measure of extra pyramidal adverse drug reactions. ABCB1 genotyping was performed by polymerase chain reaction in real time (Real-time PCR) using allele-specific hybridization. According to the survey were identified statistically significant patterns between ABCB1 polymorphism and the efficacy and safety profile of haloperidol.

M S Zastrozhin

rudnmed@yandex.ru
Russian Medical Academy of Postgraduate Education
Moscow, Russia

RUDN University; Moscow Research and Practical Centre for Narcology of the Depertament of Public Health

K A Rizhikova

rizhikkristi69@gmail.com
Russian Medical Academy of Postgraduate Education
Moscow, Russia

K B Mirzaev

mirkarbad@mail.ru
Russian Medical Academy of Postgraduate Education
Moscow, Russia

Jh A Sozaeva

sozaevazhanneta@yandex.ru
Russian Medical Academy of Postgraduate Education
Moscow, Russia

E A Grishina

grishinaea55@mail.ru
Russian Medical Academy of Postgraduate Education
Moscow, Russia

D A Sychev

dmitrysychev@gmail.com
Russian Medical Academy of Postgraduate Education
Moscow, Russia

L M Savchenko

lms1956@mail.ru
Russian Medical Academy of Postgraduate Education
Moscow, Russia

Yu Sh Gushina

gushinayusha@yandex.ru
RUDN University
Moscow, Russia

S R Pahomov

pahomovserg11@mail.ru
Moscow Research and Practical Centre for Narcology of the Depertament of Public Health
Moscow, Russia

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Copyright (c) 2017 Застрожин М.С., Рыжикова К.А., Мирзаев К.Б., Созаева Ж.А., Гришина Е.А., Сычев Д.А., Савченко Л.М., Гущина Ю.Ш., Пахомов С.Р.

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